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Showing 1 to 14 of 14 for “"Settore BIOS-06/A - Fisiologia"”.
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NEW PERSPECTIVES ON POSTURAL CONTROL IN CHILDREN AND ADULTS
Background: The main objective was to explore how the central nervous system (CNS) regulates the different neural mechanisms aimed at maintaining static and dynamic posture. The research activity RA-1 involved the postural analysis of children with neurological or neuromuscular diseases with the …
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ON THE METABOLIC AND MECHANICAL DEMANDS OF WALKING: THE EFFECTS OF SLIDING FRICTION, LIMB SWING WORK, AND BOUT DURATION.
Researchers have long investigated the metabolic and mechanical demands of locomotion. Discoveries in such field not only have advanced our understanding of the physiology of movement and energy transformations, but have also impacted anthropology, zoology, sports science, and clinical medicine. …
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UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
Vestibular schwannoma (VS) is a benign peripheral nerve tumour arising from Schwann cells (SCs) of the vestibulocochlear nerve (VN) and represents the most common tumour of the cerebellopontine angle. Although the loss of NF2/merlin is a well-established driver of schwannoma (SCH) formation, likely …
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Taste physiological mechanisms and their health implications, analyzed by genetic, epigenetic, and artificial intelligence analyses
Taste perception is a complex trait influenced by genetic, epigenetic, physiological, and pathological factors, with significant implications for nutrition, health, and disease. Our studies integrated molecular biology, psychophysics, and advanced machine learning methods to explore …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
Leucine-Rich Repeat Kinase 2 (LRRK2) is a large protein encompassing multiple functional domains, including kinase and GTPase enzymatic activity and several protein-protein interaction modules. It is expressed in the central nervous system (CNS) and it is among the most important genetic risk …
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Neural Mechanisms of Motor Imagery and Training-Induced Plasticity: Hypnotizability Relevance to Microgravity Adaptation
Long exposure to extreme environments, such as microgravity during spaceflights, induces weightlessness-related physiological alteration regarding sensory information, sensorimotor integration, and interoceptive and vestibular feedback disruption. Such alterations impair postural control, spatial …
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EXPLORING PHYSIOLOGICAL, PATHOLOGICAL AND PARAPHYSIOLOGICAL BRAIN ACTIVITY ACROSS SCALES WITH SIMULTANEOUS INVASIVE AND NON-INVASIVE EEG
This thesis explores the integration of non-invasive high-density electroencephalography (hd-EEG) with invasive stereoelectroencephalography (SEEG) to enhance understanding of brain electrophysiology in pathological, physiological and paraphysiological contexts. The combination of these two …
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NOVEL THERAPEUTIC APPROACHES EMERGING FROM HCN CHANNELS STRUCTURAL AND FUNCTIONAL STUDIES
Hyperpolarization-activated cyclic-nucleotide gated 1 (HCN1) channels are the molecular determinants of the cationic Ih current that regulates spontaneous electrical activity and synaptic integration in neurons. Mutations in the HCN1 gene have been linked to Early Infantile Epileptic Encephalopathy …
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AMPK-MEDIATED LONG-TERM REGULATION OF HCN4CONTRIBUTES TO AGE-RELATED SINUS BRADYCARDIA
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels mediates inward depolarizing currents, called If in the heart and Ih in the brain, that contribute to the regulation of neuronal excitability and cardiac rhythm. Among the HCN isotypes, HCN4 stands out for its prominent role in …
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Visual perception of social groups in zebrafish
Many animals live in groups and often make decisions based on the behaviour of others, integrating information coming from multiple social partners. The number of conspecifics performing a given action is often a key determinant of individual behaviour. Accordingly, the nervous system must extract …
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DECODING MUSCLE EXCITATION IN RESISTANCE TRAINING: A HIGH-DENSITY SEMG APPROACH
Resistance training (RT) is a primary stimulus for neuromuscular and structural adaptations, yet the characterization of muscle excitation during RT remains limited by methodological constraints. Traditional surface electromyography (sEMG) provides a global estimate of muscle activity but lacks the …
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EFFECTS OF ARTIFICIALLY - INDUCED INTRINSIC POSITIVE END - EXPIRATORY PRESSURE IN MECHANICALLY VENTILATED PATIENTS WITH ACUTE RESPIRATORY FAILURE.
It has been suggested that, in patients with acute respiratory failure (ARF), relative to conventional mechanical ventilation with application of external positive end-expiratory pressure (PEEPe), mechanical ventilation artificially inducing intrinsic PEEP (PEEPi) worsens arterial oxygen tension …