Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Settore BIO/19 - Microbiologia Generale"”.
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Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
Introduction Bacterial Outer Membrane Vesicles (OMVs) are naturally produced by all Gram-negative bacteria and are emerging as an attractive vaccine platform. The exploitation of OMVs in cancer immunotherapy was tested by decorating them with cancer epitopes and by following their capacity to …
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Bacterial lipoproteins: sorting mechanisms and biotechnological applications
The mechanism responsible for lipoprotein sorting is conserved among bacterial species. However, the final destination of lipoproteins may vary among species. In some species lipoproteins are surface-exposed while in others they are associated to the outer membrane but facing the periplasm. To …
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Acquisition and Exclusion of Pathogenicity Island 1 (PAPI-1) in Pseudomonas Aeruginosa
… virulence genes and a major regulator of biofilm formation and antibiotic-resistant traits and was found to be horizontally transferable into strains lacking it. The conjugation of PAPI-1 island transfer is mediated by type IV pilus, which is encoded by ten genes located in PAPI-1. …
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
The search for new targets and antiviral agents is continuously growing, especially for agents with broad-spectrum activity. In fact, even though vaccines are the elective way to limit diseases and possibly eradicate pathogens, they are not always effective, particularly in people with compromised …
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From Fossils to Function: Exploring the Evolutionary And Functional Diversity Of HERV Envelope Proteins Across Primate Lineages
… among retroviral elements that impacts host biology.
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Characterization of Human Endogenous Retrovirus sequences identifed in the human genome using the RetroTector software
… genome. The human genome assembly GRCh 37/hg19 was analyzed with RetroTector software and a total of 3290 HERV proviral sequences were identified. The complex genetic structure of the 3290 proviruses was resolved through a multi-step classification procedure that involved a novel type of …
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A computational approach for identification and development of novel inhibitors targeting viral polymerases
… with more recent approaches including structural biology and computational modeling can work efficiently to hasten discovery of active molecules. The ability to design drugs interfering with the progression of infection of virus comes with i)the knowledge of pathological, cellular and molecular …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
The Human Immunodeficiency Virus (HIV) integrates its genome into the host DNA and persists for the lifetime of the infected cell. Even in the presence of an efficacious Highly Active Anti-Retroviral Therapy (HAART) treatment, a pool of latently infected cells persists and reactivates to produce …
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Biochemical, computer, and spectroscopic techniques applied to the study of prions and of combinations of antineoplastic drugs
… activity in vitro (Pivetta et al., J Inorg Biochem. 2011 and 2012). Binary combinations comprising CDDP and Cu(II) complexes revealed (Part I, Chapter I) a strong synergistic cytotoxic effect against leukemia cell lines (Pivetta et al., Talanta 2013). The synergistic effect was confirmed in …
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Characterization of the human endogenous retrovirus HERV-‐K(HML-‐6) and HERV-‐K(HML-‐10) sequences and analysis of their expression
… of HERVs to significantly interfere in human biology, in both physiological and pathological scenarios. However, despite a few cases such as the one of Syncityn--‐1, the HERV physiological role an their involvement in the development of diseases such as cancer, autoimmune diseases, neuronal …
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… of tissue-resident T-cells in response to a dysbiotic composition of the gut microbiota. In particular, the pathogenesis of CD has been linked to a significant enrichment of pathogenic IFNγ-producing Th17 cells with a concomitant selective and significant enrichment of adherent-invasive E. coli …
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Characterization of ftsA conditional lethal mutants shows that FtsA is required at early and late stages of cell division in Streptococcus pneumoniae
… of 8000 transformants screened, three, named A19TS, A20TS and A21TS, were identified and shown to carry mutated ftsA alleles and express the corresponding mutated protein. The mutations mapped in different domains of the FtsA structure, thought to be involved in FtsA polymerization, …
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Studio dell’attività antivirale e/o anti-infiammatoria di nuove molecole di sintesi e/o di farmaci noti
This thesis collects the work I have done during the three-year of my PhD Course. During my first year I have started a path that has allowed me to acquire different techniques to set up and culture animal cell lines as well as to evaluate the cytotoxic and anti-picornavirus activities of a class …
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Characterization and comparison of microbial communities from different tourist ports in Mediterranean Sea and evaluation of applicability of bioremediation treatments
… ecosystems represent the greatest volume of the biosphere and the largest surface of the planet. They are home to an enormous diversity of animals, plants and microbes and are crucially important resource for fishing, transport, mining and recreation. Humans have been dependant on the seas and …
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Micro electrochemical sensors and PCR systems: cellular and molecular tools for wine yeast analysis
Nowadays, exciting bioanalytical microsystems are currently receiving increasing attention in biology since they can comply with the considerable demand for reliable, sensitive and low-cost analysis tools. Small reagents volumes, low power consumption, portability, fast analysis, high throughput …
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A phylogenetic framework for large-scale analysis of microbial communities
The human microbiome represents the community of archaea, bacteria, micro-eukaryotes, and viruses present in and on the human body. Metagenomics is the most recent and advanced tool that allows the study of the microbiome at high resolution by sequencing the whole genetic content of a biological …
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Unique gene expression profiles of microglia and astrocytes following innate immune activation
Both astrocytes and microglia are often activated in association with diseases of the central nervous system (CNS), including virus-induced neurological disease. Understanding how activation alters the transcriptome of these cells may offer valuable insight in regards to how activated cells mediate …
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