Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Settore BIO/18 - Genetica"”.
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PLANT TOLERANCE TO DROUGHT: MODULATION OF TRANSCRIPTION FACTORS
… of water are used in agriculture, and abiotic stresses, especially drought and increased salinity, are primary causes of crop loss worldwide. Various approaches may be adopted to consume less water in agriculture, one of them being the development of plants that use less water yet …
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Overcoming radioresistance by targeting p21 in cancer
… response, proposing its potential as a biomarker and therapeutic target to overcome radioresistance in cancer.
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HISTONE-DEPENDENT AND HISTONE-INDEPENDENT PATHWAYS FOR RAD9 CHROMATIN RECRUITMENT AND CHECKPOINT ACTIVATION
… this mechanism have been outlined by genetic and biochemical means in budding and fission yeasts, thanks to their genetic versatility and experimental tractability. The current model predicts that activation of the first checkpoint kinase in the cascade is not due to the DNA damage itself, but it …
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THE ARABIDOPSIS THALIANA ABC TRANSPORTERS TAP1, NAP8 AND ATH12 EXTRUDE PEPTIDES FROM CHLOROPLASTS AND ARE LINKED TO CHLOROPLAST PROTEIN HOMEOSTASIS MAINTENANCE.
… ai cianobatteri tramite un antico evento endosimbiontico, in maniera simile a quanto accaduto per il mitocondrio. Come vestigi delle sue origini, il cloroplasto possiede un genoma che ancora esprime poche proteine plastidiali. Come diretta conseguenza, il proteoma del cloroplasto è un mosaico di …
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Ethical, Legal and Social/Societal Implications (ELSI) of Recall-by-Genotype (RbG) approaches in the Cooperative Health Research in South Tyrol (CHRIS) study on genetic risk factors of Parkinson’s disease (PD)
… policies employed in different research and biobanking con-texts. Then, a secondary analysis of interviews and surveys from a mixed-methods study with CHRIS RbG participants from the RbG pilot study (RbG1) followed. Alongside the second follow-up RbG study (RbG2) study, we then designed a …
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THE MESENCHYMAL IDENTITY OF NF-YA LONG ISOFORM: FROM VERTEBRATE EVOLUTION TO CANCER
… con elevato NF-YARatio. Tramite un’analisi filogenetica nei vertebrati ho scoperto pattern distinti nello splicing di NF-YA, con NF-YAl prevalentemente espresso in campioni differenziati/associati al mesoderma. Ho evidenziato un’isoforma esclusiva negli uccelli, NF-YAg, e un retrogene, NF-YAr, …
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Spatial representation from birth to old age: Insights from comparative neurobiology and behavioral genomics.
Finding one’s way back to a safe refuge or recalling the best place to find food is essential to all animals including human beings. We engage in future actions based on past events. So how does our brain compute such important cognitive tasks? Is it an innate ability we have from birth that is …
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Role of chromatin condensates in tuning nuclear mechano-sensing in Kabuki Syndrome
The human genome is characterized by an extent of functions that act further than its genetic role. Indeed, the genome can also affect cellular processes by nongenetic means through its physical and structural properties, specifically by exerting mechanical forces that shape nuclear morphology and …
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DIETARY INTERVENTIONS TARGETING GLUCOSE METABOLISM AND HYPERINSULINEMIA: A NEW TRANSLATIONAL PERSPECTIVE FOR THE MANAGEMENT OF ACUTE INTERMITTENT PORPHYRIA
… the demand of heme production, the delayed heme biosynthesis leads to the accumulation of porphyrins ’precursors, involved in neurotoxicity, and hyperactivity of ALAS1, the first rate-limiting enzyme of the heme pathway. AIP clinical manifestations presents in 0.5-1% of HMBS-mutation carriers and …
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Translational control mechanisms in the p53 response network
The sequence-specific transcription factor p53 is considered a master gene of cellular responses to homeostasis changes. It is also a prominent tumor suppressor gene with the title of “guardian of the genome”. The increasing number of transcriptome analyses in cell lines treated with different …
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INSIGHTS INTO THE GENETIC DIVERSITY OF ASIMINA TRILOBA: A STUDY USING GENOME ASSEMBLY AND POPULATION GENETICS
… genome by assembling a draft genome using PacBio's Sequel II long reads and polishing with Illumina short reads. We first used a genotype-by-sequencing (GBS) to genotype 124 individuals from 28 sites across the state of Virginia to produce a set of single nucleotide polymorphisms (SNPs). We …
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FUNCTIONAL CHARACTERIZATION OF VPS13 DURING SEXUAL AND APOMICTIC PLANT REPRODUCTION: THE MISSING GENE FOR PLANT BREEDING?
Nei prossimi anni, la produzione agroalimentare dovrà aumentare per assicurare cibo alla popolazione mondiale in continua crescita. La generazione di ibridi è uno dei metodi per incrementare la produttività, poiché questi si contraddistinguono per le migliori caratteristiche rispetto alle linee …
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Viral metagenomics and phylogenomics for One Health
… major health challenges, from the rise of antibiotic resistance to the emergence of new pathogens with pandemic potential. This highlights the importance of considering human health as inextricably intertwined with that of other animals and the environment in which they live. This paradigm is …
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FUNCTIONAL ANALYSIS OF TRANSCRIPTION FACTORS INVOLVED IN REPRODUCTIVE MERISTEM IDENTITY IN ARABIDOPSIS THALIANA
… and AGAMOUS-LIKE 72 (AGL72) that are phylogenetically related to SOC1, are also involved in the floral transition of both the shoot apical meristem and axillary meristems and moreover, are involved in the gibberellin pathway. The soc1 agl42 ami::agl71-72 mutant shows an aerial rosettes …
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REGULATING CYTOKININ METABOLISM DURING INFLORESCENCE MERISTEM DEVELOPMENT TO PROMOTE HIGHER RICE PRODUCTIVITY THROUGH CHANGES ON PLANT ARCHITECTURE
… duration, as well as its interaction with other abiotic stresses. Since CKX genes have also been shown to be involved in plant tolerance to various abiotic stresses, we analyzed the germination rates of our different osckx mutants under water-deficit conditions generated using polyethylene glycol …