Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"Settore BIO/14 - Farmacologia"”.
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LONG-LASTING MOLECULAR ALTERATIONS FOLLOWING EARLY LIFE STRESS IN RATS: ROLE OF GUT MICROBIOTA AND INFLAMMATION
… manifested, is still needed. Moreover, among the biological systems involved, the gut microbiota has recently been proposed to act at the interplay between the stress response system, brain functionality and inflammatory processes, through the gut-brain-immune axis communication. To better …
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Towards precision medicine in psychiatry: investigating the contribution of cellular aging, pleiotropy and gender differences in psychiatric disorders and pharmacological response
… integrating demographic, clinical, lifestyle and biological characteristics. Novel analytical approaches that allow to leverage pleiotropy to improve the yield of existing genome-wide summary statistics might also be of help to identify novel potential drug targets. In this thesis, we focus on the …
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50-kHz ultrasonic vocalizations in hemiparkinsonian rats repeatedly treated with dopaminomimetic drugs as a possible behavioral marker of the affective properties of dopamine-replacing therapy in Parkinson's disease
The current leading therapeutic strategy used to manage Parkinson’s disease (PD) is the so-called dopamine replacement therapy (DRT). However, the prolonged use of DRT is associated with the onset of both motor and non-motor complications. The latter include alterations in the emotional state and …
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Anorexia nervosa: investigation of markers of neuroinflammation, oxidative stress and synaptic plasticity using the activity-based anorexia rat model.
Anorexia nervosa (AN) is a life-threatening eating disorder in which a disturbed perception of body image leads to severe caloric restriction often accompanied by other maladaptive behaviours aimed at further reducing body weight, such as excessive physical activity or purging methods. The …
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Neuropathological role of alpha-synuclein: major contribution of inflammation in the evolution of both motor and non-motor symptoms of Parkinson’s disease
Neuroinflammation is nowadays considered a cardinal pathological feature of Parkinson’s disease (PD), in which glial cells lose their homeostatic function in favour of a pro-inflammatory profile. Such sustained glial response within the brain parenchyma is characterized by a chronic release of a …
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CARATTERIZZAZIONE FARMACOLOGICA E FUNZIONALE DI NUOVI LIGANDI DEI RECETTORI COLINERGICI NICOTINICI NEURONALI CHE MODULANO IL RILASCIO DI DOPAMINA NELLA VIA MESOSTRIATALE, UNA VIA IMPORTANTE PER GLI EFFETTI COMPORTAMENTALI DELLA NICOTINA.
The α6β2∗ neuronal nicotinic acetylcholine receptor (nAChR) subtype expressed in the dopaminergic mesostriatal pathway mediates many behavioural effects of nicotine, and is selectively blocked by the small disulfide-rich α-conotoxins PIA and MII. Both share a "ω-shaped" topology but PIA bears a …
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EARLY LIFE STRESS EXPOSURE AND HYPOTHALAMIC PITUITARY ADRENAL AXIS: FROM MECHANISMS TO PERIPHERAL BIOMARKERS OF VULNERABILITY
… a carico del neurosviluppo e di altri meccanismi biologici, come ad esempi quelli infiammatori. Alla luce di queste evidenze, lo scopo di questo progetto è stato quello di approfondire il ruolo dell’asse HPA e dei geni coinvolti nella sua regolazione, i geni stress correlati, nel mediare gli …
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INVOLVEMENT OF OXIDATIVE BALANCE IN THE ETIOLOGY, PATHOPHYSIOLOGY AND TREATMENT OF STRESS-RELATED PSYCHIATRIC DISORDERS
… pathways), both important players in the neurobiology of psychiatric disorders. Considering the choice of the CMS paradigm, it is important to underline that this model is able to produce two different subpopulations of stressed animals: the vulnerable one, that develops the anhedonic …
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DEVELOPMENT OF NEW OLIGODENDROCYTE-BASED MODELS TO IDENTIFY PHARMACOLOGICAL AGENTS WITH REMYELINATING ACTIVITY
Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, characterized by neuroinflammation and demyelination. While immunomodulatory disease-modifying drugs offer relief from MS symptoms in its relapsing-remitting forms, they do not support remyelination in the …
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USE OF MULTIPLE ANALYTIC APPROACHES TO IDENTIFY NEW MARKERS/RISK FACTORS FOR CARDIOVASCULAR DISEASES AND EVALUATE THEIR ROLE AS POSSIBLE PHARMACOLOGICAL TARGETS
… analisi trasversali basate sui dati della UK Biobank, uno studio prospettico di coorte con dati genetici, fisici e clinici, raccolti su circa 500.000 partecipanti volontari di età compresa tra i 40 e i 70 anni reclutati in tutto il Regno Unito. L'accesso a questo database biomedico su larga …
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THE EFFECTS OF PRENATAL STRESS EXPOSURE DURING ADOLESCENCE: A BEHAVIORAL AND MOLECULAR CHARACTERIZATION
… presentano alterazioni nei meccanismi biologici. Successivamente, lo stress acuto ha alterato l’attività di neuroni eccitatori e inibitori, mostrato da animali PNS aventi uno sbilanciamento del rapporto eccitazione/inibizione (E/I ratio) nella corteccia prefrontale che è più …
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