Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Settore BIO/13 - Biologia Applicata"”.
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ALTERAZIONI MICROSCOPICHE DELLA DECOMPOSIZIONE:IMPLICAZIONI PER LA MEDICINA LEGALE
… histological, histochemical, ultrastructural and biochemical analyses have been proposed. The differential diagnosis between vital and post-mortem bone injuries may be more difficult both during macroscopic and microscopic examination: also in these cases histological, histochemical, biochemical …
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DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… Such information will be important to unveil the biological bases of neuromuscular disorders characterizing SARS-CoV-2 infection and the so called long-COVID symptoms. At the same time, we observed that iPSC-Human Cortical Organoids (HCO) were productively infected by SARS-CoV-2, probably by …
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ZEBRAFISH (DANIO RERIO) AS A MODEL SYSTEM FOR THE FUNCTIONALVALIDATION OF CANDIDATE GENES FOR HUMAN DISEASES
In recent years, zebrafish (Danio rerio) has become increasingly utilized as a model for studying human gene functions and associated diseases. This has been possible due to the very high conservation of genes and of organs and systems which are fully functional within the very first days of …
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NEURAL PRECURSOR/STEM CELL-BASED THERAPY: A NOVEL THERAPEUTIC APPROACH FOR THE TREATMENT OF RETT SYNDROME
… on brain of the same transplanted animals. Bioinformatics analyses revealed several deregulated pathways, mostly upregulated and associated with the immune system, in Mecp2 KO mice treated with NPCs compared to the control group. Among these pathways emerged the upregulation of that one …
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VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
Voltage gated sodium channels (VGSCs) are multimeric protein complexes formed by one alpha subunit, responsible of pore formation and of the regulation of the state of the channel, and by one or two accessory beta subunits that have an important role in the regulation of alpha subunit localization …
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CROSS-DISEASE ANALYSIS OF MOLECULAR AND CELLULAR MECHANISMS IN KIF5A-ASSOCIATED NEURODEGENERATIVE DISORDERS
… substrates. Interestingly, the aberrant biochemical behaviour of the ALS mutant N999Vfs*40 KIF5A was more severely recapitulated by the NEIMY mutant C975Vfs*73 KIF5A, which shares the last portion of its abnormal C-terminal tail yet causes a neurodevelopmental disorder, on the opposite …
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