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Showing 1 to 20 of 112 for “"Settore BIO/11 - Biologia Molecolare"”.
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Cis and Trans, p53 and NF-kB rules of transactivation
… are among the most studied proteins in tumour biology, typically known to function as antagonists, although recent studies identified example of positive, even cooperative interactions. p53 and NF-kB act as dimer or dimer of dimers, bind cis regulatory elements (referred herein as Response …
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Characterization of Small Molecules Inhibiting the RNA Binding Protein HuR
HuR, the ubiquitously expressed member of the ELAV (embryonic lethal abnormal vision) family of RNA binding proteins, selectively binds to AREs (AU-rich elements) and mainly stabilizes ARE-containing mRNAs, e.g. TNFα, VEGF, c-FOS, favoring specific protein translation. TNFα mRNA is one of the most …
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Functional characterization of the RNA binding protein RALY
… in this variability by regulating many steps of biological processes regarding RNA metabolism. The heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to big family of RBPs involved in many aspects of RNA metabolism including RNA stability, intracellular transport and translation. More …
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DEFINING THE ROLE OF THE PCGF3-CONTAINING POLYCOMB REPRESSIVE COMPLEX 1 IN SYNOVIAL SARCOMA
… affinity of the fusion oncoprotein for H2AK119ub, the histone modification deposited by Polycomb Repressive Complex 1 (PRC1). However, the precise molecular mechanisms underlying SS18-SSX transformation remain unclear. Given SS's disruption of epigenetic regulators SWI/SNF and Polycomb …
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THE SUBTLE BIOFILM REGULATION IN ESCHERICHIA COLI: CSGD AND THE YDDV-DOS OPERON
… and EAL proteins, on their modulation in E. coli biofilm formation in response to environmental signals and on regulation of curli fibers, cellulose and poly-N-acetylglucosamine (PNAG), the most important biofilm determinants in E. coli. E. coli is an Enterobacterium, normally living inside the …
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IDENTIFICATION OF NCAM1 AS A NOVEL PROGNOSTIC PROSTATE CANCER STEM CELL BIOMARKER
… marker for predicting distant metastasis and biochemical recurrence and its expression in radical prostatectomy biopsies concurred with diagnostic biopsies (concordance 87.6%). Using the human cell lines, LNCaP (androgen-sensitive) and DU145 (androgen-insensitive), we found that NCAM1, but not …
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INVESTIGATING GENOME PROTECTION AT G-QUADRUPLEXES: STRUCTURAL-FUNCTIONAL ANALYSIS OF S. CEREVISIAE DOMESTICATED TRANSPOSASE VID22
… implicate nella modulazione di numerosi processi biologici, inclusi la trascrizione e la replicazione. Di conseguenza, la perturbazione dell'omeostasi delle G-tetradi è associata ad alterazioni nell'espressione genica, a stress replicativo, a rotture del DNA e, in ultima analisi, a un aumento …
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ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
Exploiting the capacity of oncolytic viruses (OVs) to selectively target and destroy tumor cells while triggering robust antitumor immune responses offers a highly promising avenue in cancer immunotherapy. Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 …
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UNRAVELING TAZ REGULATION IN BREAST CANCER BY CRISPR SCREENING
YAP and TAZ are transcriptional coactivators belonging to the Hippo signaling pathway. Their activity is regulated by a complex network of upstream signals. As consequence, they orchestrate a wide spectrum of downstream cellular responses. In physiological conditions, a precisely balanced …
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A MOLECULAR UNDERSTANDING OF ANEUPLOID CELL CLEARANCE
Chromosome segregation errors can lead to aneuploidy, an abnormal chromosome number associated with cancer and genome instability. My Ph.D. research focused on understanding the interplay between aneuploid cells and the immune system. By utilising mass spectrometry and the Surfaceome database, I …
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