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Showing 1 to 20 of 83 for “"Settore BIO/10 - Biochimica"”.
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PLASMA MEMBRANE ASSOCIATED GLYCOHYDROLASES: KINETICS PARAMETER CHARACTERIZATION AND BIOLOGICAL FUNCTION
… at pH 5.7, beta-hexosaminidase at pH 5.10 while beta-galactosidase, SMase and beta-hexosaminidase A at pH 5.45. We could distinguish between CBE sensitive beta-glucosidase and GBA2 beta-glucosidase using specific inhibitors that are CBE and AMP-DNM respectively, therefore we determined …
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A PROPOSED NEW INTERNAL STANDARD FOR FREE, GLYCOSYLATED AND TOTAL PYRIDINIUM CROSSLINKS QUANTIFICATION IN HEALTHY WOMEN AND CHILDREN URINE: VALIDATION OF AN HPLC-FLUORESCENCE METHOD
Emerging evidence supports the concept that biochemical markers are clinically useful as non invasive diagnostic tools for the monitoring of changes in bone and cartilage turnover in subjects affected by pathologies with destructive bone and joint diseases such as osteoporosis, osteoarthritis, …
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INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS
Alternative splicing (AS) is vital for proteome flexibility and its aberrations are key drivers of cancer progression. We identified an alternatively spliced exon cassette in myosin VI, an actin motor protein. In healthy epithelial tissues like the ovary and intestine, this exon cassette is …
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SURVIVING UNDER PRESSURE: TRANSLATIONAL REWIRING IN RESPONSE TO MECHANICAL STIMULI
… linked to the regulation of the cell cycle and biosynthesis processes. This connection suggested that achieving density homeostasis could involve a coupling mechanism between the regulation of macromolecular production and osmolytes. Considering the importance of density and protein homeostasis, …
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DISSECTING THE ROLE OF NEDD4 HECT E3 LIGASE AND ITS ISOFORMS IN CANCER
… ones exerted by isoform 1. In order to unveil biological and biochemical features of NEDD4 isoform 3, we started analyzing its cellular localization and ubiquitination activity. In addition, co-immunoprecipitation coupled with proteomic experiment led to the identification of exclusive NEDD4 …
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LIPID-BASED APPROACHES TO OPTIMIZE THE EFFECTIVENESS OF INNOVATIVE DRUG MODULATORS IN CYSTIC FIBROSIS
… In fact, the ganglioside GM1 is an important bioactive sphingolipid that has been reported to play a crucial role in the control of several plasma membrane (PM) proteins and its correlation with CFTR prompts speculations about its possible role in the CFTR interactome. Despite therapeutic …
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MOLECULAR CHARACTERIZATION OF PROTEINS IN FOOD MATRICES: HOW THEIR STRUCTURE EVOLVE FROM RAW MATERIALS TO FINISHED PRODUCTS
… of the food systems. Technological and biotechnological treatments used in food processing are also responsible for the formation of new inter- and intra-molecular interactions, driven by changes in the structure of proteins, often in association with other food components. In the …
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UNDERSTANDING THE PRO-SURVIVAL ROLE OF AIF: STRUCTURAL AND FUNCTIONAL STUDY OF AIF-CHCHD4 COMPLEX
… l’omeostasi energetica cellulare promuovendo la biogenesi e la funzione dei complessi respiratori multi-subunità. Sebbene i meccanismi molecolari alla base non siano stati ad oggi chiariti, è noto che questo ruolo è svolto grazie all’interazione di AIF con CHCHD4, una proteina solubile dello …
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