Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Serum Response Factor"”.
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Serum response factor-dependent regulation of smooth muscle gene transcription
… to the proliferative/dedifferentiated one. Serum response factor (SRF) is the major transcription factor that plays an essential role in coordinating a variety of transcriptional events during this phenotypic change. The first goal of my thesis studies is to determine how SRF regulates the …
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Serum Response Factor Regulates Multiple Aspects of Central Nervous System Development
… conserved activity-dependent transcription factor. Previous studies have shown that neuron-specific deletion of SRF results in deficits in tangential cell migration, guidance-dependent circuit assembly, activity-dependent gene expression, and synaptic plasticity in the hippocampus. However, …
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Overexpression of Serum Response Factor in Astrocytes Improves Neuronal Plasticity in a Model of Fetal Alcohol Spectrum Disorders
… cAMP and cGMP levels, activating transcription factors such as the cAMP response element binding protein (CREB) and the Serum response factor (SRF). SRF is important for many plasticity processes such as LTP, LTD, spine motility and axonal pathfinding. Here we attempt to rescue OD plasticity in …
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Regulation of Inverted Formin-1 (INF1) by Microtubule-Affinity Regulating Kinase 2 (MARK2)
… able to induce F-actin formation, activate the Serum Response Factor (SRF) pathway, stabilize microtubules, associate with microtubules, and disperse the Golgi body. Regulation of INF1 is unique, since it does not possess conserved formin regulatory domains. However, INF1 does possess many …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
… Bioinformatic analysis reveals an enrichment of serum response factor (Srf) targets amongst genes upregulated following Lats1/2 deletion. Ablating Srf in the Lats mutant background causes Lats;Srf mutant cells to undergo epithelial to mesenchymal transition but not progress to fulminant tumors in …
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Transcriptional Regulation of the Xenopus MyoD Gene
MyoD is one of the MRFs (Muscle Regulatory Factors) and it functions to determine the muscle cell fate. The mechanism by which MyoD regulates the muscle development program is very well understood. However, the transcriptional regulation of the MyoD gene itself has not studied in Xenopus. In this …
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Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El
… of quiescent cells into the cell cycle following serum stimulation. These genes are involved in growth control and differentiation and hence their expression is tightly controlled. Many IEGs are regulated through Serum Response Elements (SREs) in their promoters, which bind Serum Response Factor …
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
Partnerships between DNA binding transcription factors and transcriptional cofactors govern gene transcription in various developmental and tissue contexts, particularly during cardiovascular and neuronal development. This dissertation aims at studying the in vivo relevance of the partnership …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… various cytokines, including transforming growth factor-β (TGF-β), to promote tissue repair. In response to these biochemical cues, VF fibroblasts undergo a fibroblast-to-myofibroblast transition. While myofibroblasts are required for wound closure and VF repair, persistent myofibroblast …
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The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors
… rates and increased levels of CYCLIND1 in a serum dependent manner when compared with wild type MEF cells. The reduced proliferation in wild type cells was mediated through up-regulation of CYLD by transcription factor serum response factor (SRF) in a p38 mitogen-activated protein kinase …
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Estrogen action in the myocardium
… attention to estrogen as a potential protective factor in the heart. So far the focus of research and clinical studies has been the vascular system, leaving the current knowledge on the role of estrogen in the myocardium itself rather scarce. Functional estrogen receptor-alpha as well as -beta …