Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Sertoli cells"”.
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The role of conexin 43 in murine sertoli cell development
Sertoli cells are the only somatic cell type present within the seminiferous tubules of the testis. The support of these somatic cells is essential for testis formation and spermatogenesis. They are called mother or nurse cells, implicating their intimate association with germ cells and also their …
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Thyroid Hormone Effects on Sertoli Cell Gene Expression in the Rat
… stimulating hormone (FSH), regulate neonatal Sertoli cell development. It was not clear however, if all of the changes seen in Sertoli cell development during hypothyroidism represent direct effects of thyroid hormone deficiency on the Sertoli cells, or if some effects result from secondary …
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The effects of green tea, green rooibos and their major flavonoids (EGCG and aspalathin) on testicular cell health in vitro
… steroidogenesis and of spermatogenesis. Leydig cells, located at the testicular interstitium, produce predominantly testosterone upon stimulation with either chorionic gonadotropin (CG) or luteinising hormone by a series of enzymatic modifications of cholesterol. Sertoli cells respond to …
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THE APPLICATION OF HISTONE ANALYSIS FOR IDENTIFYING DISTAL REGULATORY ELEMENTS - REGULATION OF FSHR
… Fshr is a gene expressed only in testicular Sertoli cells and ovarian granulosa cells and its expression is critical for proper gonad function and fertility. Importantly, underlying its exquisite cell-specificity is a transcriptional mechanism limited to only two cell types, which previous …
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Equilibrative Nucleoside Transporter Mediated Drug Disposition Across the Blood-Testis Barrier
… barrier (BTB) protects developing germ cells by limiting entry of toxicants. This protective barrier poses a problem for therapeutic disposition to the male genital tract, which may allow viruses or cancer to persist in the testis, and impedes the development of male contraceptives and …
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Localization of nerve growth factor-β in the stallion reproductive tract
… tract and would primarily be localized in Sertoli cells of the testis and the prostate gland. Immunohistochemistry on paraffin embedded paraformaldehyde fixed tissues was performed using a rabbit polyclonal anti-NGF-β antibody on a total of six male equine reproductive tracts, including a …
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Coregulatory Transcription Factors and Spermatogenesis
… revealed the following: both ETV5 and germ cells were necessary for seminiferous epithelial CLD5 expression; CLD5 expression was ETV5 independent in vascular endothelium; and CLD5 was expressed in both Sertoli cells and spermatogonia. Data presented here support the conclusion that Sertoli …
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Pengaruh infusa daun murbei (Morus alba L.) terhadap gambaran histologi dan berat testis tikus putih (Rattus norvegicus) diabetes mellitus kronik
… skunder, spermatid dan spermatozoa), sel sertoli, diameter tubulus seminiferus, dan berat testis. Data yang diperoleh dianalisis dengan ANOVA One Way, apabila terdapat perbedaan sangat nyata maka dilanjutkan dengan uji lanjut Duncan α 1%. Hasil penelitian menunjukkan bahwa infusa daun …
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Role of androgens in testicular development and dysgenesis
… abnormal development and function of the somatic cells. It is thought that the suppressed intratesticular testosterone levels associated with TDS may account for subsequent low sperm counts, via a reduction in perinatal Sertoli cell proliferation/number. Sertoli cells do not express androgen …
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The Role of Axl and Axl-like Proteins in Murine Spermatogenesis
… their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous epithelium. A sequence homology search identified an uncharacterized protein, AXL-LIKE, which we hypothesize is an endogenous dominant-negative of AXL. The structure of AXL-LIKE …
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Personalised Risk Assessment of Low-dose Radiation Effects on Spermatogenesis
… distribution of exposed and unexposed cells in the irradiated tissue. To establish a personalised risk assessment for the effects of low-dose radiation on spermatogenesis, we investigated significant alterations in spermatogenesis in response to non-uniform radiation distributions at …
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Depletion of docosahexaenoic acid (DHA) and arachidonic acid causes male infertility by disrupting both secretory granule biogenesis and adherens junction assembly in testis
… and supporting the proper maturation of germ cells within the testis. Here, we sought to define the molecular nature of this HUFA-deficient male infertility, with an emphasis on spermatid adhesion and acrosome formation. Dietary ARA or DHA was found to be sufficient in restoring the …
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DEVELOPMENT OF NOVEL BIOTECHNOLOGICAL APPROACHES FOR ACCELERATING GENETIC GAIN IN THE BOVINE
… was placed on the generation of male haploid cells in bovine species. However, in vitro spermatogenesis remains a major challenge in large mammals and has, to date, been successfully accomplished only in rodents. To address this limitation, a stepwise approach was adopted to develop targeted …
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Impact of chemotherapy on the release and function of extracellular vesicles in the pre-pubertal testis
… are small lipid-bound structures released by all cells within the body and are a method of cell-to-cell communication. They mediate their effects on recipient cells through the delivery of cargoes and interaction with cell surface receptor ligands. The cargoes of EVs are numerous and include RNA, …
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Identifying the mechanism critical for proliferation, apoptosis, and cell-cell interaction in the development of mouse adrenals and gonads
… Steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs, but also controls their differentiation. In this thesis project, I used Sf1/Cre transgenic mice to generate different types of knockout models to study the development of …
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The activin a pathway in fetal testis development and dysgenesis in the mouse
… expression, I observed significant reductions in Sertoli cell proliferation leading to impairment of testis cord elongation and coiling. Using a conditional knockout approach, I was able to pinpoint the murine fetal Leydig cells as the primary source of interstitial Inhba/activin A. To identify …
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The Sodium Pump Regulates Sperm and Sertoli Cell Function
… (the sodium pump) isoforms in sperm function, Sertoli cell function and male fertility. In fresh bovine sperm, I identified two distinct pools (raft and non-raft) of the testis-specific isoform of Na/K-ATPase (ATP1A4) in the plasma membrane. The raft pool of ATP1A4 interacted with caveolin-1 …
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Effects of Quaternary Ammonium Disinfectants on Mouse Reproductive Function
… ADBAC+DDAC were cytotoxic to testicular Sertoli cells in culture at concentrations greater than or equal to 0.0005%. Changes in blood-testis-barrier integrity (BTB) were observed at 0.01% ADBAC+DDAC using a two-compartment culture system that measures transepithelial electrical resistance …
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Apoptotic markers in ejaculated human spermatozoa
… dysfunctional or genetically damaged germ cells and is necessary to maintain an optimal germ cell to Sertoli cell ratio. The formation of the bloodtestis barrier requires the elimination of excessive germ cells and a surge of germ cell apoptosis occurs prior to puberty regulating the ratio …
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