Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Sertoli cell"”.
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The Sodium Pump Regulates Sperm and Sertoli Cell Function
… (the sodium pump) isoforms in sperm function, Sertoli cell function and male fertility. In fresh bovine sperm, I identified two distinct pools (raft and non-raft) of the testis-specific isoform of Na/K-ATPase (ATP1A4) in the plasma membrane. The raft pool of ATP1A4 interacted with caveolin-1 …
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The role of conexin 43 in murine sertoli cell development
Sertoli cells are the only somatic cell type present within the seminiferous tubules of the testis. The support of these somatic cells is essential for testis formation and spermatogenesis. They are called mother or nurse cells, implicating their intimate association with germ cells and also their …
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Thyroid Hormone Effects on Sertoli Cell Gene Expression in the Rat
… stimulating hormone (FSH), regulate neonatal Sertoli cell development. It was not clear however, if all of the changes seen in Sertoli cell development during hypothyroidism represent direct effects of thyroid hormone deficiency on the Sertoli cells, or if some effects result from secondary …
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Neonatal estrogen and androgen disrupted sertoli cell proliferation, leading to inhibited testosterone synthesis in adulthood
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Role of androgens in testicular development and dysgenesis
… or in young adulthood (testicular germ cell cancer and low sperm counts), are common and may be increasing in incidence. These disorders have a common fetal origin and share risk factors; consequently they are hypothesized to comprise a testicular dysgenesis syndrome (TDS). TDS arises …
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The activin a pathway in fetal testis development and dysgenesis in the mouse
… activin A can elicit changes in target cell proliferation, differentiation, and function via the SMAD signaling pathway. Inhibin βA (Inhba), the gene encoding activin A, is expressed within the interstitial compartment of murine and human fetal testes; however, the role of Inhba/activin …
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Coregulatory Transcription Factors and Spermatogenesis
… revealed the following: both ETV5 and germ cells were necessary for seminiferous epithelial CLD5 expression; CLD5 expression was ETV5 independent in vascular endothelium; and CLD5 was expressed in both Sertoli cells and spermatogonia. Data presented here support the conclusion that Sertoli …
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The effects of green tea, green rooibos and their major flavonoids (EGCG and aspalathin) on testicular cell health in vitro
… steroidogenesis and of spermatogenesis. Leydig cells, located at the testicular interstitium, produce predominantly testosterone upon stimulation with either chorionic gonadotropin (CG) or luteinising hormone by a series of enzymatic modifications of cholesterol. Sertoli cells respond to …
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Multi-cycle cisplatin treatment alters spermatogonial functional stem cell behavior and niche
… spermatogonia, including spermatogonial stem cells (SSCs), are theoretically capable of repopulating the seminiferous tubules after exposure has ceased. It is proposed that an altered spermatogonial environment during recovery from the initial treatment cycle may drive an increase in SSC …
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Expression and function of basigin during early pregnancy and spermatogenesis
… for the interactions between gametes and Sertoli cells during spermatogenesis. BSG protein was expressed in the uterine epithelium at estrus in βERKO mice but not in αERKO mice. However, a higher level of Bsg mRNA was observed in the uteri of αERKO mice as compared with wild type (WT) and …
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Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
… at the plasma membrane in primary human Sertoli cells and mouse Sertoli cell culture systems using quantitative polymerase chain reaction, immunoblotting and confocal immunofluorescence microscopy, respectively. In mouse Sertoli cell culture systems, using radiolabeled and fluorescent …
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Effects of cocaine on male fertility
… transferrin demonstrates its adverse effects on Sertoli cell function.
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Structure-function studies of human SLC36 amino acid transporters
… the membrane (with optimum uptake at an extracellular pH of 5.5). Their main substrates were found to be the small neutral amino acids glycine, alanine and proline; however, in addition to these, PATs 1 and 2 were also observed to transport a range of other substrates including some …
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Effects of Quaternary Ammonium Disinfectants on Mouse Reproductive Function
… ADBAC+DDAC were cytotoxic to testicular Sertoli cells in culture at concentrations greater than or equal to 0.0005%. Changes in blood-testis-barrier integrity (BTB) were observed at 0.01% ADBAC+DDAC using a two-compartment culture system that measures transepithelial electrical resistance …
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Distribution and biosynthesis of LH-RH and structurally related peptides
… Monkey, pig and dog testes as well as dog Sertoli cell tumours were extracted with acetic acid and shown to contain LH-RH immunoreactive material similar to that of the rat. Human seminal plasma was also investigated as a source of LH-RH-IR. When pooled seminal plasma from azoospermic males …
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Apoptotic markers in ejaculated human spermatozoa
The role of male germ cell death in spermatogenesis is an important one as it removes dysfunctional or genetically damaged germ cells and is necessary to maintain an optimal germ cell to Sertoli cell ratio. The formation of the bloodtestis barrier requires the elimination of excessive germ cells …
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Impact of chemotherapy on the release and function of extracellular vesicles in the pre-pubertal testis
… fertility, as it damages the spermatogonial stem cell (SSC) niche within the testis. This niche is essential for future fertility as these SSCs will differentiate into sperm following the onset of puberty. In post-pubertal males, this can be somewhat mitigated by the use of sperm cryopreservation …
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The role of the Fused toes locus containing Iroquois homeobox gene 3, 5, and 6 and Ftm, Fto, and Fts during ovary and testis development in mice
… absence of the the Ft locus, the primordial germ cells (PGC) develop normally, however, many PGC fail to migrate to the genital ridge and fail to proliferate once they reach the genital ridge. Failure of the PGC migration and proliferation causes a significant reduction in the number of germ …
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PATHOLOGY OF THE UROGENITAL TRACT IN DOMESTIC ANIMALS
… I studied the expression of an extracellular matrix protein called periostin in normal bladder and dog urothelial carcinomas. The tumour microenvironment is considered one of the main players in cancer development and progression and may influence the behaviour of cancer cells. …