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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Serpin"”.
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Eine phylogenetische Analyse von Serpin-Genen aus eukaryotischen Genomprojekten
Die Superfamilie der Serpine (Serinprotease-Inhibitoren) umfasst neben inhibitorischen Serpinen auch nicht-inhibitorische Proteine. Eine geeignete Serinprotease spaltet die auf der Serpin-Oberfläche exponierte, reaktive Schleife (reactive centre loop, RCL) als Pseudosubstrat und wird dadurch …
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Serpin polymers enforce molecular filtration in the endoplasmic reticulum
… is the serine protease inhibitor (serpin) that is secreted mainly by hepatocytes and acts in lungs where its major function is to inhibit neutrophil elastase. Neuroserpin is a serine protease inhibitor expressed in the nervous system. Mutations in these two proteins can cause them …
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Estrogen Inducible Serpin, Proteinase Inhibitor 9, in Immunosurveillance and Apoptosis
The phytoestrogen genistein has attracted a great deal of recent interest. In MCF-7 cells, we find that 10 nM genistein induces PI-9 as effectively as saturating E2, and genistein treated MCF-7 cells are resistant to NK cell mediated cytotoxicity. In ERalphaHA cells, the dose response curves for …
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Design and synthesis of small-molecule inhibitors as anti-malarial and anti-serpin agents
<p>This work describe the design, synthesis and evaluation of small-molecule inhibitors of two different biological targets: <em>Plasmodium falciparium</em>, the most virulent malarial parasite in humans, and plasminogen activator inhibitor-1 (PAI-1), an endogenous serine proteases inhibitor …
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Proteases, antiproteases and other inflammatory mediators associated with Chronic Obstructive Pulmonary Disease (COPD)
… and its endogenous serine protease inhibitor (serpin), alpha1 anti-trypsin. This protease-antiprotease imbalance can be a result of a genetic deficiency of alpha1 anti-trypsin, however, less than 5% of COPD patients possess the deficiency suggesting that other protease-antiprotease imbalances …
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Discovery and validation of novel blood biomarkers of breast and prostate cancer
… assess the biomarker potential of five proteins: Serpin B1, Lipocalin 2, Copine 3, Integrin 4 and 5LOX, using Western blot, immunofluorescence, flow cytometry and ELISA techniques. Serpin B1, Lipocalin 2, 5LOX and Copine 3 were present in neutrophils, whereas Integrin 4 was detected in …
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Phylogenomics of vertebrate serpins
The serpins constitute a superfamily of proteins that fold into a conserved tertiary structure and employ a sophisticated, irreversible suicide-mechanism of inhibition. More than 6000 serpins have been identified, occurring in all three forms of the life - the eukaryotes, the prokaryotes and the …
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Study of apoptotic deletion mediated by Bifidobacterium longum with construction of recombinant strains for Serpin encoding gene and phenotypes comparison in a pig cell model
… that have top scores homologies with the recent serpin encoding gene identified in B. longum by Nestlè researchers. Bifidobacterium longum is a probiotic, known for its beneficial effects to the human gut and even for its immunomodulatory and antitumor activities. Recently, many studies have …
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Investigation into the structure and function of Hsp47
… triggers a conformational change in the serpin, which is vital for the function of Hsp47. It is this structural transition upon a change in pH that was exploited in the investigation into the regions of importance of for Hsp47-collagen binding. Most of the previous works examining the …
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Protein structural dynamics and thermodynamics from advanced simulation techniques
… Finally, the conformational changes occurring in serpin proteins are studied. The serpins are very flexible, with a large size, more than 350 residues, and slow dynamics, from hours to weeks, completely beyond the possibilities of the simulation techniques to date. In this thesis we present the …
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Role of new virulence mechanisms/factors (type 3 secretion system and TOX-R regulated lipoprotein [TAGA]) in the pathogenesis of the emerging human pathogen Aeromonas hydrophila
… of complement by binding to and cleaving the serpin C1-INH. By recruiting C1-INH to the surface of the bacteria and cleaving it, TagA is able to significantly prevent the activation of complement at the cell surface, ultimately increasing the serum resistance of the pathogen. TagA can also …
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Progress toward a structure-function relationship for novel, small-molecule inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor-1 (PAI-1) is a serpin protein whose function is to inhibit tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and hence, fibrinolysis. This inhibition leads to decreased plasminogen to plasmin conversion, which results in …
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Design, synthesis, and biological evaluation of non-symmetric smal
… activator inhibitor-1 (PAI-1) is a member of the serpin family of proteins, a primary inhibitor of both tissue-type and urokinase-type plasminogen activators in plasma, and is a well-established risk factor in various disease conditions. Increased levels of active PAI-1 in plasma are correlated …
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Structure-activity relationships of PAI-1 inhibitors
… bind to PAI-1 with a low affinity, inhibit the serpin plasma protein antithrombin III, and/or fail to inhibit PAI-1 when vitronectin, a cofactor of PAI-1 is present. The synthesis of small-molecule inhibitors of PAI-1 that improve upon these properties has been the main goal of this research. …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… and adiponectin in weight gain. Also, resistin, serpin A12, IGFBP4, cathepsin-S and Angiopoetin-2 in MRD risk. We have shown that leptin, IL-8, serpin A12 and angiopoietin-2 have a protective effect when incubated with the Molt4 ALL cell line and that resistin does not offer this …
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Molecular Signatures of gastric cancer: An integrated approach to molecular cytogenetics, whole genome copy number and transcriptome profiles
… Immunohistochemical staining of 18q proteins, Serpin B8 and CD226 antigen, showed overexpression in breakapart-positive primary gastric cancers. Other molecular signatures from whole genome copy number, mRNA and miRNA profiles are described.
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Generation of novel small molecules as inhibitors of plasminogen activator inhibitor-1
… is a member of the serine protease inhibitor (serpin) family of proteins, which inhibits certain serine proteases, such as tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and thus is a primary regulator of fibrinolysis, the process that results in …
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Synthesis and structure activity relationship of novel small molecules as inhibitors of plasminogen activator inhibitor-1
… is a member of the serine protease inhibitor (serpin) family. PAI-1 is involved in the regulation of fibrinolysis, which is the breakdown of blood clots. PAI-1 inhibits serine proteases tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which are key factors …
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Towards development of new strategies for inhibiting skin cancer progression
… overexpression of serine protease inhibitors (serpins). Vaspin (also known as visceral adipose tissue-derived serpin; serpinA12) is the most recently identified serpin. Vaspin is expressed in the skin epidermis, its expression is dysregulated in psoriatic skin, but its potential role in …
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