Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Serotonin-Release"”.
-
Tryptophan availability modulates serotonin release
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1990.
-
Die Rolle von KATP-Kanälen bei der evozierten Serotonin-Freisetzung während kurz- und langdauernder Blockade des Serotonin-Transporters im Neocortex der Ratte und der Maus
… Superfusionstechnik konnte der [3H]-Noradrenalin-Release im Neocortex der Ratte durch KATP-Kanal-Blockade abhängig von der Einwirkzeit der Uptake-Blocker modifiziert werden. Im Rahmen dieser Arbeit sollte geklärt werden, ob sich der [3H]-Serotonin-Release im Ratten- und Mauscortex ebenfalls durch …
-
The Effect of Cholecystokinin Antagonist Lorglumide on Dopamine Levels in the Rat Caudate
… of systemic lorglumide on DA turnover and release in the rat CPu. Turnover estimates based on the depletion of DA following α-mpt or by evaluation of DOPAC/DA ratios failed to reveal a significant difference when lorglumide-treated animals were compared to saline treated controls. Further, …
-
1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine (Platelet Activating Factor): Interactions with Sheep Platelets
… PAF was characterized in terms of aggregation, serotonin release, ATP release and phosphatidic acid formation but also with a new and more satisfactory method based on platelet shape change. The development of the latter was based on microscopic and rheooptic observations but is also supported …
-
Opiate Regulation of Lordosis: Neurochemical Evaluation of the Role of Opiate-Serotonergic Interactions
… turnover, but decreased the rate of serotonin turnover in the POA. These changes were not seen in other areas of the brain. Both naltrexone and morphine increased the rate of serotonin synthesis in the POA. The dissociation between the rates of serotonin synthesis and turnover is …
-
Determinants of Abuse-Related Effects of Monoamine Releasers in Rats
Monoamine releasers constitute a class of compounds that promote release of dopamine, serotonin, and/or norepinephrine. These compounds have a range of different uses in the medical setting, including treatment of attention deficit hyperactivity disorder, narcolepsy, and obesity. A major limitation …
-
CYP2D in the Brain Alters Response to Drugs and Neurotoxins
… in the brain, enhanced striatal dopamine and serotonin release, exacerbated acute methamphetamine-induced rearing, and enhanced repeated methamphetamine-induced stereotypy sensitization. Next, to assess the role of human CYP2D6 in brain in vivo, humanized CYP2D6-expressing transgenic mice and …
-
Single cell analysis by capillary electrophoresis with laser-induced native fluorescence detection
… were degranulated on-column, and exocytosis and serotonin release were monitored temporally;First, single red blood cells, in which Hb molecules exist in their native, tetrameric states were analyzed. Upon injection and lysis of a cell, the tetramers were dissociated on-column into their …
-
Activation of 5-HT1A Receptors in the Nucleus Tractus Solitarius Facilitate Ventilatory Responses to Hypoxic Hypercapnia and Promote Sympathetic Recovery Following Hypotensive Hemorrhage
… chemoreceptor stimulation. Thus, we propose that serotonin is released in the NTS during hemorrhage to activate 5-HT<sub>1A</sub> receptors which facilitate chemoreflex responses. We utilized viral-mediated knockdown of the rat 5-HT<sub>1A</sub> receptor in the caudal NTS (cNTS) to examine the …
-
Familiar Food-Induced Feeding Activation in C. Elegans
… and the physiological context of action of serotonin, an endogenous activator of pharyngeal pumping. Here I show that like food, serotonin increases overall feeding by activating both feeding motions. Serotonin activates the two feeding motions by activating two distinct neural pathways. A …
-
The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
The role of the neurotransmitter serotonin (5-HT) in the taste bud is not well understood. Serotonin was long thought to be the neurotransmitter of taste signals from taste receptor cells (TRCs) to the gustatory afferent nerves, but the surprising discovery that this transmission is actually …
-
Neural Computation Through Synaptic Dynamics in Serotonergic Networks
… where they reveal fundamental tradeoffs between release probability, number of synapses sampled, and statistical power. 2. Synaptic dynamics and population computations in the serotonin system. This part is comprised of two manuscripts. First, in the dorsal raphe nucleus, I uncovered slow, …