Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Serotonin receptor"”.
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Serotonin receptor mechanisms in anti-depressant action
Serotonin neurones have been implicated in the pathophysiology and treatment of clinical depression to a greater degree than any other neurotransmitter. Additionally, serotonin pathways may playa role in the pathophysiology and treatment of eating disorders, anxiety states and schizophrenia. …
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Expression and function of serotonin receptor isoforms in the respiratory system
Eine Vielzahl unterschiedlicher Serotoninrezeptoren moduliert die neuronale Netzwerkaktivität mittels G-Protein aktivierter Signaltransduktionswege. Spezifische poly- und monoklonale Antikörper gegen die 5-HT2B, 5-HT4(a) und 5-HT7 Rezeptoren wurden generiert, um deren Verteilung im respiratorischen …
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Structure Activity Relationships for Intracellular Loop 2 of the 5HT1A Serotonin Receptor
… for Intracellular Loop 2 of the 5HT1A Serotonin Receptor</p> <p>Chairperson: Dr. Keith Parker </p> <p> The human (H) serotonin (5-hydroxytrptamine; 5HT) 1a receptor (R) has been implicated in various physiological processes such as mood regulation, vascular and temperature control, …
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Structure Activity Relationships for Intracellular Loop 2 of the 5HT1A Serotonin Receptor
… for Intracellular Loop 2 of the 5HT1A Serotonin Receptor</p> <p>Chairperson: Dr. Keith Parker </p> <p> The human (H) serotonin (5-hydroxytrptamine; 5HT) 1a receptor (R) has been implicated in various physiological processes such as mood regulation, vascular and temperature control, …
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Cell Type Specific Roles of Serotonin Receptor 4 in the Hippocampus and Neocortex in Emotion and Cognition
… Preclinical studies indicate a critical role for Serotonin Receptor 4 (5-HT<sub>4</sub>R, product of the Htr4 gene) in this direction as drugs that activate this receptor show fast-acting antidepressant-like properties. Unfortunately, 5-HT<sub>4</sub>R is widely expressed in the periphery, …
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The synthesis of WAY-derivatives to find linker location and a new linker to attach a fluorescence tag for homo- or hetero-dimer of 5-HT receptor ligands
Serotonin action or inaction is known to correlate with depression, obesity and drug addiction. The serotonin receptor has been studied as a possible target for cocaine addiction therapy. Previously, 5-HT 2A receptor antagonist, M100907 and 5-HT 2C receptor agonist, WAY 163909 have been studied as …
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Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development
… phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition and the relationship of these changes to the deficits in pre-pulse inhibition (PPI) caused by PCP treatment. Postnatal rats were treated with atypical or typical antipsychotics or selective dopamine or serotonin receptor …
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The use of enzymes, isomerisable lipid analogues and small molecules to modulate the structure and dynamics of lipid bilayer
… samples containing cholesterol and the serotonin receptor agonist drugs quipazine and LY-165,135 was analysed using proton and deuterium NMR spectroscopy and differential scanning calorimetry (DSC). The effect of quipazine and LY-165,135 on d62-DPPC was an elongation of the gel-to-fluid …
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Characterization of an Evolving Serotonin Transporter Computational Model
… structure and function of a central target, the serotonin transporter (SERT). Established SERT inhibitors (SSRIs) were docked to an in silico SERT model to identify likely binding pocket amino acid residues. When mutated singly, no one of five implicated residues was critical for high affinity in …
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Synthesis and Characterization of 1-Methyl-4-Substituted-3-Piperidine-Carboxylic Acid N, N-Diethyamide.
… (d-LSD) all act at the same site, namely, the serotonin (5-hydroxytryptamine) receptor in the brain, it was found that 1-methyl-1,2,5, 6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC), a compound similar in structure to the D-ring of LSD (Figure 1), blocked the behavioral disruption in …
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Hormone Regulation of NPY Neuron Activity in the Arcuate Nucleus of the Hypothalamus
… by which insulin, leptin, ghrelin, and serotonin acutely modify the electrical activity of these neurons remains unclear. To determine ion channels that are coupled to hormone and neurotransmitter receptors present on NPY neurons, whole-cell patch clamp electrophysiology was performed on …
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Automated, highly scalable RNA-seq analysis
… of Tsc1. We show that upregulation of the serotonin receptor Htr2c causes aberrant calcium spiking in the Tsc1 knockout mouse, and implicate it as a novel therapeutic target for tuberous sclerosis. The third chapter of this work investigates transcriptome regulation in the superior …
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On the Binding of N1-substituted Tryptamines at h5-HT6 Receptors
Serotonin was first discovered in the late 1940s as a vasotonic factor and is now considered a principal neurotransmitter in the nervous system. 5-HT6 receptors are one of the most recently identified members of the serotonin receptor family which consists of seven classes (5-HT1-5-HT7). 5-HT6 …
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The design, synthesis, and biological evaluation of aplysinopsin analogs as potential neuromodulators
… 50 aplysinopsin analogs revealed that of the 12 serotonin receptor subtypes and 34 other CNS receptors, aplysinopsin analogs shoa high affinity for the 5-HT2B and 5-HT2C receptor subtypes, with selectivity for 5-HT2B over 5-HT2C. Bromination at C-4 and C-5 of the indole ring resulted in greater …
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Targeted Disruption of the Deaf1 Gene in Mouse Brain and the Effects on Behavior and Gene Expression
… has been reported to alter 5-hydroxytryptamine (serotonin) receptor 1A (<italic>Htr1a</italic>) levels in the frontal cortex and dorsal raphe nucleus. We hypothesized that mice with targeted deletion of <italic>Deaf1</italic> in brain would produce behavior phenotypes analogous to human MDD and …
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Modulation of Prefrontal Cortex activity and sociability by local interneurons expressing corticotropi-releasing hormone
… of a proposed circuit model for cortical serotonin receptor 3 (5-HT3AR) interneurons enriched with corticotropin-releasing hormone (CRH), generated using these established frameworks. Molecular profiling using Translating Ribosome Affinity Purification (TRAP-seq) predicted an elegant, …
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Familiar Food-Induced Feeding Activation in C. Elegans
… and the physiological context of action of serotonin, an endogenous activator of pharyngeal pumping. Here I show that like food, serotonin increases overall feeding by activating both feeding motions. Serotonin activates the two feeding motions by activating two distinct neural pathways. A …
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Neurotransmitter Modulation of Alcohol-Induced GABAergic Signaling in the Central Amygdala
… (OXT), corticotropin-releasing factor (CRF), and serotonin (5-HT) have demonstrated therapeutic potential in reducing alcohol-related behaviors. However, how these neuromodulators alter GABAergic transmission in the CeA and interact with alcohol, particularly at the circuit level, remains poorly …
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Part I: Disruption of PTEN-5-HT2CR Coupling: A Potential Treatment for Restoration of 5-HT2CR Function / Part II: Rapid Total Synthesis of Cyclodepsipeptide MA026
PART I Serotonin 2C receptor (5-HT2CR) plays an important role in regulation of physiology, behavior, and dysfunction in 5-HT2CR neurotransmission may underlie some psychiatric disorders (e.g., depression, drug addiction). The association of the 5-HT2CR with protein phosphatase and tensin homologue …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
The role of the neurotransmitter serotonin (5-HT) in the taste bud is not well understood. Serotonin was long thought to be the neurotransmitter of taste signals from taste receptor cells (TRCs) to the gustatory afferent nerves, but the surprising discovery that this transmission is actually …
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