Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Serine protease inhibitor"”.
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Serpin polymers enforce molecular filtration in the endoplasmic reticulum
… and cause disease. Alpha1-antitrypsin is the serine protease inhibitor (serpin) that is secreted mainly by hepatocytes and acts in lungs where its major function is to inhibit neutrophil elastase. Neuroserpin is a serine protease inhibitor expressed in the nervous system. Mutations in these …
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Isolation and characterization of starch, starch biosynthetic genes and protease inhibitors from Marama beab (Tylosema Esculentum)
… marama starch biosynthesis genes and detect serine protease inhibitor activities in green and mature marama seeds. The total starch content of marama bean tubers was determined by amyloglucosidase/α-amylase enzymatic digestion and amylose content by Concanavalin A precipitation. A …
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Characterization of subtilisin-like serine proteases in trichomonas vaginalis
… found worldwide. In this study, subtilisin-like serine proteases (subtilases) were examined for their putative role in cell viability. Published data of other eukaryotic protozoan parasites confirm the importance of subtilases for adhesion and invasion. Serine protease inhibitor assays show that …
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Generation of novel small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor (PAI-1) is a member of the serine protease inhibitor (serpin) family of proteins, which inhibits certain serine proteases, such as tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and thus is a primary regulator of …
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Synthesis and structure activity relationship of novel small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) family. PAI-1 is involved in the regulation of fibrinolysis, which is the breakdown of blood clots. PAI-1 inhibits serine proteases tissue-type plasminogen activator (tPA) and urokinase-type …
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Design, synthesis and evaluation of small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. Excessive levels of PAI-1 inhibit urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA), which regulates fibrinolysis as well as the development of …
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Identification of SPINK2 as biomarker of primary chemoresistance in acute myeloid leukemia and its biochemical role in normal bone marrow.
… appartenente alla famiglia SPINK (Serine Protease Inhibitor Kazal-type). SPINK2 è tipicamente noto come inibitore dell’attivazione prematura dell’acrosina nello spermatozoo; tuttavia, in questo lavoro di tesi tramite analisi di single-cell RNA-seq sono stati rilevati alti livelli …
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Molecular properties of aspartate transcarbamoylase and related enaymes from wheat
… During the course of these investigations, a protease was detected which was shown to co-migrate with ATCase and DHOase activities. This protease was shown to be insensitive to the serine protease inhibitor PMSF, but was partially inactivated by iodoacetamide, consistent with the protease …
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Common messenger molecules and cell types demonstrating neuroendocrine-immune interactions in the chicken
… of the chicken was reported. Previously the serine protease inhibitor, ovoinhibitor, was localized in bursal follicles, specifically the cortico-medullary border region. The presence of ovoinhibitor was identified and confirmed in the chicken pituitary by this study. Continued focus on the …
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The role of Moraxella catarrhalis outer membrane proteins in pathogenesis
… bacterium is known to bind ACT. The ACT is a serine protease inhibitor playing important part in antiprotease lung protection and anti-inflammatory signalling. We established that M. catarrhalis is able to bind and inactivate ACT through the two active domains on both UspA1 and A2 proteins. …
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Proteases, antiproteases and other inflammatory mediators associated with Chronic Obstructive Pulmonary Disease (COPD)
… better methods of diagnosis. The presence of a protease-antiprotease imbalance within the airways contributes to the chronic inflammation and proteolytic destruction of the lung tissue observed in COPD. The most defined example of the protease-antiprotease imbalance within COPD occurs between …
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Genomics and virulence factors of Fusobacterium necrophorum
… were not statistically significant. Ecotin, a serine protease inhibitor, was found to be present in 100 % of the strain collection and had a highly conserved sequence with primary and secondary binding sites exposed on opposing sides of the protein. During enzyme inhibition studies, a purified …
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Investigation of the role of neuroserpin in neurite outgrowth and learning and memory
Neuroserpin is a serine protease inhibitor, or serpin, that is expressed in the nervous system and inhibits the protease tissue plasminogen activator (tPA). Neuroserpin has been shown to play a role in neurite outgrowth but con icting results have been reported. Neuroserpin has also been proposed …
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Imbalance Between Neutrophil Elastase and Elafin Promotes Breast Cancer Growth and Progression
<p>Elafin, an endogenous serine protease inhibitor, is a critical component of the epithelial barrier against neutrophil elastase (NE) activity. The central hypothesis examined in this dissertation was that elafin has tumor suppressive properties in breast cancer. In support of this hypothesis, …
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Differential Stimulation of Monocytes to Secrete Secretory Leukocyte Protease Inhibitor by Lipopolysaccharide of Periodontal Pathogens
… mononuclear phagocyte cells. Secretory Leukocyte Protease Inhibitor (SLPI) is a single-chain serine protease inhibitor secreted from secretary and inflammatory cells that protects tissue from damage caused by the inflammatory response. The present study examined the interaction of LPS prepared …
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Investigation into the structure and function of Hsp47
… transport of collagen chains. It is also a non-inhibitory member of the serine protease inhibitor superfamily and uses the pH-dependent mechanism, common to all members of this protein family, for binding and release to/from its substrate. A reduction in the pH of the environment triggers a …
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The control of melanogenesis in early avian embryos
… epidermis . Melanocytes may also need to produce proteases in order to invade the epidermis since raft culture of skin in TLCK, a serine protease inhibitor, prevented epidermal melanisation. Finally, the ability of the epidermis to chemotactically attract melanocytes was investigated by assessing …
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Molecular cloning, structural characterisation and functional study of bioactive peptides from amphibian skin secretion
… has attracted much attention in the fields of protease inhibitor peptides and antimicrobial peptides. In this study, the skin secretion of two frogs, Amolops hainanensis and Odorrana versabilis, were obtained by use of electrical stimulation. Afterwards, ‘shotgun’ cloning was applied using …
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Control of the release of digestive enzymes in the cricket Gryllus bimaculatus and the fall armyworm, Spodoptera frugiperda
… release. In crickets, the continuous release of proteases is sufficient to meet the needs for growth, and only moderate stimulation of trypsin results from feeding. Carbohydrates are used for energy, and the release of amylase is adjusted to the amount of food ingested. The neuropeptide …
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