Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Serine/threonine protein kinases"”.
-
WNK Family Kinases and the Regulation of Ion Flux
… of the with no K (lysine) or WNK family of serine/threonine protein kinases have an unusual arrangement of their catalytic lysines. WNK1 and WNK4 have been genetically linked to a rare type of hypertension. Studies demonstrate that these kinases regulate the activity of a diverse group of …
-
Low Temperature Induced Signaling and Molecular Responses in Tomato
… based on the finding of a highly phosphorylated protein (pp34) and two sequentially activated serine/threonine protein kinases during the initial stage of rewarming. By using rubisco activase as a model gene, my study shows that chilling may interfere with the normal expression of photosynthetic …
-
Characterization of C-Gmp Dependent Kinases Within the Circadian Molecular Clockworks: Structural, Phylogenetic, and Functional Analyses
cGKI and cGKII are paralogous serine/threonine protein kinases. In an effort to determine the mechanism by which the circadian molecular clockworks differentially regulates the activity of these kinases a comparative biology approach was employed. This work included phylogenetic and 3-dimensional …
-
Exploring the Functional Interaction Between CaMK-II and p53
… member of a family of Ca2+/calmodulin-dependent serine/threonine protein kinases that respond to transient intracellular calcium signaling. CaMK-II has been reported to be involved with transcription regulation, cell motility, neuronal development, cell cycle regulation, and more recently early …
-
Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin Ligase
<p>The Par-1 family of serine/threonine protein kinases functions to regulate cell polarity and is conserved from yeast to humans. Par-1 is encoded by one of six Par: partitioning-defective) genes: Par-1-6) originally identified in a genetic screen conducted in Caenorhabditis elegans: C. elegans). …
-
The role of PAK6 in HGF-induced prostate cancer cell migration
… GTPases Rho A, Racl and Cdc42 and their effector proteins, p21-activated kinases (PAKs), which are a family of mammalian serine/threonine protein kinases. PAK6, a PAK family member, is over-expressed in prostate cancer but little is known about its function in cells. This project investigated the …
-
The Mycobacterium tuberculosis protein O-phosphorylation landscape
Protein phosphorylation is a main mechanism for translating extracellular signals into cellular adaptations. In bacteria, the two-component system has been the paradigm of protein phosphorylation. Increasingly, however, protein serine/threonine and tyrosine phosphorylation (O-phosphorylation) …
-
Nuclear Behaviors of ERK1/2 Signaling
… fibrosarcoma (Raf)- mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) kinase (MEK)- ERK pathway is essential for proper development and homeostatic regulation in eukaryotic cells. Many pathway functions are carried out by ERK1 and ERK2 (ERK1/2), …
-
Regulation of Connexin43 by Phosphorylation in Heart Development
<p>Serine/threonine protein kinases have been shown to reversibly regulate cell-cell communication through gap junctions formed by connexin 43 (Cx43) (Godwin et al.7 1993). The Cx43 protein expression levels are unclear and what role phosphorylation plays in the regulation of signal transduction …