Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 948 for “"Serine"”.
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Analysis of a bacterial serine/threonine kinase
RdoA is a bacterial protein kinase from Salmonella enterica serovar Typhimurium first noted for its regulation of dsbA expression in this organism. The crystal structure of RdoA’s homologue, YihE from Escherichia coli, revealed a basic bi-lobal kinase domain that is a hallmark of the eukaryotic …
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Insulin Receptor Substrate-1 Serine Phosphorylation by a Novel Phosphatidylinositol-3'-Kinase-Associated Serine Kinase Regulates Insulin and Interferon Receptor Signaling
… '-kinase (PI 3- kinase) associates with a novel serine kinase that can phosphorylate IRS-1 and reduce its ability to act as a substrate for insulin and interferon alpha (IFNalpha) receptors. PI 3-kinase is shown to associate with a wortmannin insensitive 76 kDa serine phosphoprotein (pp76) …
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Caldolase: an alkaline serine protease from Thermus strain TOK₃
… Included amongst them was an extracellular serine protease from a Thermus strain designated Tok₃, which was selected for further study. The protease was purified to homogeneity by ammonium-sulphate precipitation followed by ion exchange on DEAE-cellulose and QAE-Sephadex, affinity …
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Characterization of subtilisin-like serine proteases in trichomonas vaginalis
… found worldwide. In this study, subtilisin-like serine proteases (subtilases) were examined for their putative role in cell viability. Published data of other eukaryotic protozoan parasites confirm the importance of subtilases for adhesion and invasion. Serine protease inhibitor assays show that …
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Characterization of Endothelial Nitric Oxide Synthase Serine-600 Phosphorylation
… in cell cycle progression and form a class of serine/threonine kinases. The most commonly studied and well understood posttranslational modification of eNOS is phosphorylation. This work builds on our laboratory’s discovery of a phosphorylation site – ser<sup>600</sup> – on the autoinhibitory …
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Serine Starvation Modulates mRNA Splicing Through Depletion of SR Proteins
Serine is a critical nutrient for cancer cell proliferation due to its numerous downstream functions in protein, nucleotide, and lipid biosynthesis. There are ongoing clinical efforts to utilize dietary serine starvation as a potential therapy for serine auxotrophic tumors that cannot make their …
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Inhibition of Salmonella gallinarum by D-serine and its reversal
Thesis (M.S.)--Michigan State University of Agriculture and Applied Science. Dept. of Microbiology and Public Health, 1958
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The role of midgut serine proteases in Aedes aegypti vector competence
… through the alimentary tract may exploit serine proteases in the midgut to enhance vector infection. Recent genetic and biochemical experiments have demonstrated that dengue virus type 2 (DENV-2) may require proteolytic processing by midgut trypsins to efficiently infect Aedes aegypti. …
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Molecular biology studies on the extracellular serine proteases of Vibrio alginolyticus
… bacterium that produces several extracellular serine proteases and a collagenase during the stationary growth phase. The aim of this study was to investigate alkaline serine protease production by this organism, and to attempt the cloning and expression of a V.alginolyticus protease gene in …
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Characterization and regulation of serine exoproteases and collagenase in vibrio alginolyticus
… production of an extracellular collagenase and serine proteases by Vibrio alginolyticus during stationary phase was inhibited by a temperature shift from 30 to 37°C and by lack of oxygen. V. alginolyticus had identical growth rates at 30 and 37°C. Aeration did not affect the growth rate of …
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The Role of Serine Protease Inhibitors in Regulating Hepatotoxicity During Viral Infection
… 9 (PI-9/ serpinB9) and the murine orthologue, serine proteinase inhibitor 6 (SPI-6/ serpinb9) are members of a family of intracellular serine proteinase inhibitors (serpins). PI-9 and SPI-6 expression in immune-privileged cells, antigen-presenting cells, and cytotoxic T cells protects these …
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RhoA and Rac1 prenylation: Effects on serine/threonine signaling for actin polymerization
RhoA and Rac1 are small guanosine triphosphates (GTPases) that regulate cytoskeletal rearrangements, cell polarity and axon guidance and signaling pathways. Alteration of the subcellular localization or activation of Rho GTPases is implicated in several neurological conditions. Rho GTPases are …
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Profiling L-serine Transport Throughout Growth and Meiotic Maturation in Mouse Oocytes
… nutrients. This thesis focuses on the amino acid serine, which has been shown to improve outcome in developing embryos and also plays a variety of roles in the body that may carry over to oocyte health as well. Using radiolabeled [3H] serine, we measured uptake of serine as a function of time …
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