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Showing 1 to 1 of 1 for “"Sequential metabolism"”.
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IN VITRO AND IN VIVO KINETIC MODELING OF DIAZEPAM METABOLISM
Drug metabolism plays an important role in drug absorption and drug elimination. Therefore, it is crucial to understand the mechanism and kinetics of drug metabolism by various drug-metabolizing enzymes (DMEs). Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of more than 60% of …