Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Sequence-function relationships"”.
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PLASTICITY IN PROTEIN SEQUENCE-FUNCTION RELATIONSHIPS
Allostery is defined as the functional regulation at one site in a protein by activity at a distant site. Because of the ubiquitous occurrence and diverse cellular roles of allosteric proteins, designing novel allosteric proteins is of great interest for applications in synthetic biological and …
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Integrative approaches to decipher influenza evolution, antibody responses, and AI-driven specificity prediction
… areas: (1) deep mutational scanning (DMS) to map sequence–function relationships in influenza viral proteins; (2) large-scale analysis of antibody responses to SARS-CoV-2 and influenza; and (3) development of AI models to predict antibody specificity. Chapter 1 introduces the rapid advancement of …
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Exploring the Activation Landscape of Pro-Apoptotic BAK Through the Discovery of Human BH3-Only and Non-Native Peptide Binders
… structures, crosslinking data, and in vitro functional tests have provided insights into the activation event, yet the sequence-function relationships that make some, but not all, BH3-only proteins function as activators remain largely unexamined. In this thesis, I address the question using …
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High-throughput protein engineering tools for efficient exploration and quantitative mapping of protein fitness landscapes
… engineering proteins to perform fit-for-purpose functions remains a complex challenge. Its difficulty arises from two main factors: (1) the nearly boundless search space of amino acid sequences resulting from the combinatorial explosion of possible mutations, and (2) the complex sequence-function …
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Functional metagenomic discovery and characterisation of CAZymes by microfluidic methods
… sequencing projects, the number of protein sequences in databases has grown exponentially in recent years. This abundance of recorded sequence data, though, stands in contrast to the small number of experimentally verified functional annotation, which is crucial for the accurate assignment …