Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Sequence-defined Polymers"”.
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Hydrogen Bond Template-Directed Synthesis of Recognition-Encoded Melamine Oligomers
The directed evolution of biopolymers is based on the mutagenic replication of DNA. However, reliance on DNA limits the application of directed evolution to molecules that can be encoded by DNA, such as proteins. The development of a synthetic oligomer which can mutagenically replicate could unlock …
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Strategies for combinatorial development of siRNA conjugate delivery systems
… systems are attractive for their purity, well-defined structures, low ratios of delivery material to siRNA, and potentially broad therapeutic windows, yet relatively few efficacious conjugates are reported in the literature. As synthetic challenges prevent the study of large conjugate …
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Multifunctional Chemical Cross-linkers for Drug Carriers and Molecular Probes
… synthesis to study the effect of cross-linker sequence on the biophysical properties of antibody-drug conjugates. Finally, we discuss our efforts to develop molecular probes to characterize the surface of extracellular vesicles and quantify endosomal escape for siRNA therapeutics. Taken …