Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Sensory Neuropathy"”.
-
Evolution of sensory neuropathy after initiation of antiretroviral therapy
Introduction: We studied the evolution of sensory neuropathy after antiretroviral therapy (ART) in human immunodeficiency virus–infected South Africans. Methods: Enrolment commenced before ART with 6-monthly follow-ups for 24 months. Symptomatic distal sensory polyneuropathy (SDSP) was defined as …
-
Investigating Mechanisms of Nucleoside Reverse Transcriptase Inhibitor Induced Sensory Neuropathy
… HIV disease is well controlled show peripheral sensory neuropathy (PSN), supporting the idea that the ART may cause PSN. Although the nucleoside reverse transcriptase inhibitors (NRTIs) used in the ART are thought to contribute to PSN, the mechanisms underlying the PSN induced by NRTIs are …
-
A transgenic mouse model of hereditary motor and sensory neuropathy
… demyelinating form of Hereditary Motor and Sensory Neuropathies and manifests at birth in human. Some subtypes of CH are due to dominant mutations in the gene coding for PO glycoprotein, which functions as a homophilic adhesion protein, responsible for compaction of opposing myelin lamellae. …
-
HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy
Distal sensory polyneuropathy (DSP) amongst human immunodeficiency virus (HIV)-infected patients is frequently a painful and disabling condition. HIV-associated DSP is either a consequence of HIV (HIV-DSP) or antiretroviral-induced toxic neuropathy (ATN). The purpose of this research was to …
-
On the application and generation of subsensory electrical nerve stimulation for the improvement of vibration perception in patients with HIV-related sensory neuropathy
This work investigates the application of Subsensory Electrical Noise Stimulation (SENS) to improve symptoms of HIV-related peripheral sensory neuropathy (HIVPN). HIV-PN occurs in roughly half of the 5 million people in South Africa with HIV. The disease has been shown to reduce quality of life and …
-
Regeneration of Meissner Corpuscles in Diabetic Mice Following Median Nerve Crush
… in diabetes mellitus leads to the development of sensory neuropathies and causes delayed and incomplete neuronal regeneration. Diabetic sensory neuropathy has been shown to contribute to the impairment of light touch and low frequency vibratory perception. It is proposed that the regeneration of …
-
THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
… deficits are likely due to proprioceptive sensory neuropathy similar to those described by the mutant mouse strains <em>cra1</em>, <em>loa </em>and <em>Swl</em> (Chen et al., 2007; Dupuis et al., 2009; Zhao et al., 2016). Additionally, BDNF<sup> lox+/+ </sup>mice demonstrated increased PPI …
-
Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
… conduction. Chemotherapy-induced peripheral neuropathy is a major dose-limiting side effect of many other commonly used chemotherapeutic agents, including platinum drugs, taxanes, epothilones and vinca alkaloids, but also newer agents such as bortezomib. Bortezomib (VELCADE) is a boronic acid …
-
Molecular analysis of myotonic dystrophy type 1 patients with an unusual molecular diagnosis
… genetically heterogeneous, hereditary motor and sensory neuropathy of the peripheral nervous system. To date, 30 different loci have been mapped and mutations have been identified in more than 20 different genes. The DM1+CMT++ family is a very unusual three generation family in which all patients …
-
Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
… TRPV2 is another heat activated ion channel. The sensory phenotype of TRPV2 knock-out mice was studied and compared against TRPV2 wild-type mice in both hairy and glabrous skin. Mice lacking TRPV2 had normal heat sensitive nociceptors and afferents retained mechanical sensitivity. The involvement …
-
AR-A IPSCS: GENERATION OF AN ADVANCED CELLULAR MODEL TO INVESTIGATE A NOVEL THERAPEUTIC APPROACH FOR SBMA
… other systemic symptoms are present, such as sensory neuropathy, androgen insensitivity, sexual dysfunction, gynecomastia, fatty liver disease, and insulin resistance, making SBMA a disease highly impacting on patients’ life quality. SBMA is caused by an expansion of a CAG triplet repeat …
-
Assembly and substrate recognition properties of human CCT subunits of the TRiC chaperonin
… CCT5 (H147R), have been implicated in hereditary sensory neuropathy. In order to study the defective mutant proteins, we introduced these mutations into the CCT4 and CCT5 constructs. We found that for CCT4, the newly translated mutant polypeptide chains aggregated much more than wild-type (WT) …