Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Sensory Neuron"”.
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Functional Analysis of SOX11 and NF1 in Sensory Neuron Development and Plasticity
Development of sensory neurons is controlled by both cell-extrinsic and cell-intrinsic factors. The transcription factor Sox11 is abundantly expressed in embryonic sensory neurons. In the first part of this thesis, by using a Sox11-/- mouse model, I show that the loss of Sox11 results in increased …
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Glia Delimit Shape Changes Of Sensory Neuron Receptive Endings in C. elegans
<p>Neuronal receptive endings such as dendritic spines and sensory protrusions are structurally remodeled by experience. How receptive endings acquire their remodeled shapes is not well understood. In response to environmental stressors, including starvation, crowding and high temperature, the …
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Glia Are Required For Sensory Neuron Morphology And Function In Caenorhabditis elegans
… emerges from the coordinated development of neurons and glia. To better understand the processes that enable nervous system development and function we have studied the sensory organs of Caenorhabditis elegans because their anatomy and function are well-characterized. Specifically, we have …
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Mechanisms Underlying Mesenchymal Stem Cell-Derived Extracellular Vesicle Modulation of Sensory Neuron Excitability
… in a murine model of OA by reducing OA-induced sensory neuron hyperexcitability, rather than altering joint pathology. These findings underscore the therapeutic potential of MSC-EVs in pain management. We further showed that MSC-EVs can directly inhibit sensitisation of dorsal root ganglion …
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The Intricate Molecular Landscape of Insect Chemosensation: The Sensory Neuron Membrane Protein Gene Family
<p>SNMPs (Sensory Neuron Membrane Proteins) are members of a gene family characterized by human CD36. This family has diverse functions including transportation of fatty acids and interactions with other proteins in cell:cell recognition. SNMPs are membrane proteins observed to associate with …
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The impact of reduced neuronal p75NTR expression on sensory neuron phenotype and associated glia
… has been implicated in diverse responses of sensory neurons including a role in nociception following nerve injury, suggesting that it may serve a similar role in intact sensory neurons and their satellite glial cells (SGCs). To examine the impact of suppressing neuronal p75NTR expression on …
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Role of the immunoglobulin superfamily member Basigin in sensory neuron dendrite morphogenesis in Drosophila
Neurons develop highly stereotypic dendritic arbors that influence establishment of proper connections and integration of information they receive to generate an appropriate output. Morphogenesis of dendrites is coordinated by both cell-intrinsic and extrinsic factors. Recent studies have begun to …
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A Comparative Study of Sensory Neuron Synaptic Activity and the Role of Presynaptic Diversity, Specificity, and Regulation in Caenorhabitis Elegans
… presynaptic glutamate release from single chemosensory neurons in intact animals and characterize the dynamics of endo- and exocytosis from two types of glutamatergic neurons, AWC<sup>ON</sup> and ASH. In Chapter 1, we describe the optimization of Vglut-pH, we introduce a reagent for measuring …
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Novologue Therapy Improves Mitochondrial Bioenergetics and Modulates Transcriptome Changes in Diabetic Sensory Neurons
… with scarce treatment options. Impaired neuronal mitochondrial bioenergetics contributes to the pathophysiologic progression of DPN and may be a focal point for disease management. We have demonstrated that modulating Hsp90 and Hsp70 with the small-molecule drug KU-32 ameliorates …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… and balance (vestibular) organs, comprising the sensory hair cells and sensory neurons of the cochlear (spiral) and vestibular ganglia. In mammals, inner ear sensory cells undergo terminal mitosis during embryogenesis and do not regenerate. Therefore, during postnatal life, sensory cell loss is a …
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Density-Dependent Foraging in Caenorhabditis Elegans
… srx-43. Reduced expression of this gene in the sensory neuron ASI contributes to naturally occurring insensitivity to icas#9. Remarkably, I find that the QTL falls in a high-diversity region that exists in two distinct haplotypes in C. elegans populations around the world. This pattern of …
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Smooth Muscle-Specific Removal of Brain-Derived Neurotrophic Factor Results in Increased Vagal Afferent Innervation to the Intestine and Increased Satiation in Mice
… into the nodose ganglion. Nodose ganglion neurons were also quantified to investigate the contribution of vagal sensory neurons to IGLE density. Meal pattern and microstructure analyses were used to determine if any underlying changes in the mechanisms that regulate feeding were associated …
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Representations and Transformations of Odor Information in the Mouse Olfactory System
… in the external environment to receptors on sensory neurons in the olfactory epithelium. These sensory neurons transmit this odor information to neurons in the olfactory bulb via spatially stereotyped axonal projections, and a subset of these bulbar neurons, mitral and tufted cells, in turn …
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Investigating the Role of Insulin-Like Signaling in Paclitaxel-Induced Nociceptive Hypersensitivity using Drosophila melanogaster
… known to induce nociceptive hypersensitivity and sensory neuron damage in human patients and in Drosophila larvae. We used a modified feeding protocol to establish a genetically tractable Drosophila model of PTX-induced hypersensitivity. Larvae fed PTX exhibited hypersensitivity to thermal and …
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
… caused severe sickness mediated by TRPV1+ TLR4+ sensory neuron detection of the exposed lipopolysaccharide (LPS). Stimulation of lung nociceptors induced acute stress responses in the paraventricular hypothalamic nuclei by activating corticotropin-releasing hormone neurons responsible for …
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The Roles of daf-6 and Cell-Cell Interactions in Sensory Organ Morphogenesis
… development of the Caenorhabditis elegans amphid sensory organ. Sensory organs in diverse species are often composed of neuronal sensory endings accommodated in a lumen formed by ensheathing epithelia or glia. The generation of this structure may require cell-autonomous factors that control lumen …
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The Role of Wnt Signaling in Development of the Ophthalmic Trigeminal Placode.
… (opV) placode, which gives rise only to sensory neurons of the ophthalmic lobe of the trigeminal ganglion, is a well-studied model of sensory neuron development. While key differentiation processes have been characterized at the tissue and cellular levels, the molecules governing opV …
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Neurochemical characterization of the rodent primary sensory system
Primary sensory neurons and their associated tissues are important targets for neurochemical study. Disorders of the sensory system, including chronic pain and itch, can be extremely devastating and, in many cases, difficult to treat. Part of the difficulty of treating such disorders is the limited …
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CaMKIIbeta in Pain and Addiction
… Vanilloid (TRPV1). Additionally, utilizing sensory neuron specific CaMKIIβ knockout mice I determined that nociceptor specific CaMKIIβ mediates both evoked and on-going spontaneous pain in both chronic inflammatory and neuropathic pain models. I employed hematopoietic stem cell …
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Toll-like receptor expression and signalling in rat trigeminal neurons: Consequences for oral infection and mechanisms of orofacial pain.
… receptors (TLRs), expressed by peripheral sensory neurons, represents an innate surveillance function of sensory neurons with important consequences for neuronal function. Despite recent advances, many properties of neuronal TLRs remain poorly understood, particularly within the trigeminal …
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