Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Sensorimotor gating"”.
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Disruption of Prepulse Inhibition by Apomorphine Across Modalities
<p>Sensorimotor gating, the process by which organisms filter extraneous sensory stimuli, is commonly assessed with manipulations of prepulse inhibition (PPI). Alterations in gating are observed in individuals with schizophrenia, HIV-1 dementia and other neuropsychiatric disorders. Dopaminergic …
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Role of a PTP1B Pathway in the Neuropsychiatric Expression of a Mouse Maternal Immune Activation Model
… day 9.5, we observed increased locomotion and sensorimotor gating and reduced anxiety in 3-month-old male offspring while females showed decreased sensorimotor gating. These effects were not replicated in PTP1B KO mice indicating a role of PTP1B in affecting locomotion and anxiety level in MIA. …
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Prepulse inhibition come strumento diagnostico per lo studio del comportamento impulsivo-aggressivo nella schizofrenia
Sensorimotor gating is a perceptual process aimed at filtering out irrelevant information. In humans and animal models, this function can be operationally measured through the prepulse inhibition (PPI) of the acoustic startle reflex. Notably, PPI deficits are associated with numerous …
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Effects of diet on behavioural domains relevant to schizophrenia- a preclinical perspective
… of HFD mothers had significantly improved sensorimotor gating compared to offspring of control mothers but showed no altered behavioural response in tests for cognition, sociability, locomotion or exploration. In conclusion, HFD appears to affect behaviours and particular …
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mGluR5 Involvement in Methamphetamine Reward and the Co-Morbidity of Schizophrenia and Stimulant Use Disorders
… models of the disorder demonstrate deficits in sensorimotor gating, or the inability to properly filter sensory information properly. Sensorimotor gating deficits are measured in the laboratory through the use of pre-pulse inhibition (PPI) of the acoustic startle response. PPI is defined as a …
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SITUATION MOUSE ALL FLOXED UP: EXPLORING PHENOTYPIC ABNORMALITIES IN BDNF FLOXED MICE
… possible motor abnormalities, slightly impaired sensorimotor gating (SMG) or hearing loss, and reduced muscle tone. We repeated the open field and prepulse inhibition (PPI) tests and likewise found increased anxiety, possible motor abnormalities, and severely reduced PPI. This data combined with …
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Ruolo dei neurosteroidi nella modulazione dopaminergica
… by dopaminergic agents, including deficits of sensorimotor gating as well as repetitive and compulsive responses. Unlike other antidopaminergic agents, however, FIN does not elicit catalepsy or other extrapyramidal side-effects. To extend these findings, this thesis is aimed at the assessment …
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Effects of Exposure to Perinatal Ultrasound Radiation on Information Processing in the Auditory System
… inhibition tests were administered to test for sensorimotor gating, hearing, and motor response. Finally, a brainstem auditory evoke potential test was given to track auditory threshold and appropriate neural firing at various auditory nuclei. Postnatally US exposed rats showed a decreased …
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Development of a Mouse Model of NY99 West Nile Virus-Induced Neurological Changes
… with changes in behavioral tests investigating depressive-like behavior, sensorimotor gating, and motor learning, though there was no correlation with memory function. These studies show that this mouse model of WNV infection causes long-term changes in the brain that can manifest as …
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The GluK4 Kainate Receptor Subunit Regulates Mood, Memory and Excitotoxic Neurodegeneration
… behavior, reduced depressive behavior, impaired sensorimotor gating, and hyperlocomotion relative to wild-type mice. GluK4 knockout mice also demonstrated impaired fear memory and spatial memory. Furthermore, my findings indicate that GluK4 is a key mediator of excitotoxic neurodegeneration: …
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La clozapine et les neurostéroïdes dans la modulation de comportements associés au suicide dans un modèle murin de schizophrénie
… behaviors (EB) were performed to assess the sensorimotor gating, aggressiveness/impulsivity and anxiety-like responses, respectively. Results showed that (1) PPI deficits in THMS mice are normalized by clozapine treatment (2) Finasteride administration to THMS mice elicited worsen aggressive …
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Effects of perinatal phencyclidine treatment on neuronal viability, N-methyl-D-aspartate receptor regulation and schizophrenic-like behaviors
… and social discrimination) and deficits in sensorimotor gating (PPI of acoustic startle). Work within this dissertation discovered that PCP induces neurotoxicity in developing pups in a manner that is highly regulated affecting the distribution, composition, number, and function of NMDAR and …
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Examination of the Relationship between Startle Eyeblink Modulation and Perceived Fatigue in Multiple Sclerosis
… in the patterns of neural activation within the sensorimotor network (SMN), suggesting that disruptions of efficient processing within the SMN are related to fatigue perception. Extending this line of research, the present study investigated whether a psychophysiological measure of the …
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DEVELOPMENTAL CONSEQUENCES OF GESTATIONAL CANNABIS EXPOSURE IN RAT ACROSS THE LIFESPAN
… offspring performance in various tests of sensorimotor gating, MK-801 induced locomotor activity, social interaction, incidental memory, and exploratory behaviour, highlighting differences between smoke and injection exposure routes. Chapter 4 utilized X-ray Fluorescence (XFI) and Fourier …
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Ontogeny of Prepulse Inhibition Across Sensory Systems
… inhibition (PPI), employed as a measure of sensorimotor gating, is operationally defined by the presentation of a weak (prepulse) stimulus immediately prior to a startling stimulus, causing a reduction in the magnitude of the startle response. Alterations in gating are observed in …
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Bio-behavioural evaluation of efavirenz and Δ9-tetrahydrocannabinol alone and in combination in rats with respect to psychosis and anxiety
… of EFV + Δ9-THC on social interactive behaviour, sensorimotor domains as well as anxiety-like behaviour in rodents. The study (NWU-00278-17-A5) used 72 male, adolescent Sprague-Dawley rats (150g - 180g) divided into four equal groups (n = 18 per group). The animals were bred and housed under …