Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Sensor domain"”.
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Functional and Structural Studies of the Human Voltage-Gated Proton Channel
… helices (S1-S4) form the regulatory voltage-sensor domain and the last two transmembrane helices (S5 and S6) comprise the ion-conducting pore domain. It was thought that all voltage-gated cation channels shared this conserved domain architecture. However, this scheme was challenged by the …
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Estimation of the Real Area of Contact in Sliding Systems Using Thermal Measurements
… that the preferred measurement location of the sensor is not very sensitive to the contact distribution specifics. This is useful because it allows selection of measurement locations regardless of the specifics of the generally unknown contact distribution. Further results show the combined …
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Biophysical and Biochemical Characterization of a REC Domain: Unfolded to Folded Transition of EL_LovR
… these to control phosphorylation of the receiver domain of the response regulator, which convert this signal into a physiological response. Knowledge of how phosphorylation shifts receiver domains between their inactive and active states is limited, chiefly assembled from several prototypical …
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Regulation of amylovoran biosynthesis in Erwinia amylovora
… 2) Comparative characterization of RcsC sensor kinase showed that the sensor domain of RcsC was important for the regulation of bacterial virulence; 3) novel genes regulated by RcsB and RcsC were identified by microarray assays. Third, a conserved hypothetical gene amyR from E. amylovora …
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Structural characterization of superbug proteins involved in regulating beta-lactam resistance
… presents the crystal structure of the BlaR1 sensor domain (BlaRs) from S. aureus, determined in its apo form and acylated with penicillin G. These structures reveal that acylation by β-lactams is not accompanied by a BlaRs conformational change. It is also shown that mutation of the BlaR1 L2 …
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Molecular and Biochemical Analysis of the Histidine Kinase CusS and its Role in Metal Resistance in Escherichia coli
… CusR. Copper sensing by the periplasmic domain of CusS is proposed to initiate signal transduction in the Cus system. Despite the frequency with which bacteria employ histidine kinases to sense their environment, signal recognition and incorporation by the protein is not well understood. …
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Control of The Master Virulence Regulatory Gene Atxa In Bacillus Anthracis
… pXO2-61 is homologous to the sensor domain of sporulation sensor histidine kinases and is proposed to titrate an activating signal away from the sporulation phosphorelay when overexpressed by AtxA. These results indicate that AtxA is not only a master virulence regulator, but …
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Polysaccharide utilization by the human colonic bacterium, bacteroides intestinalis DSM 17393
… system encoded by organisms in all three domains of life. The two-component system is involved in signal transduction, mediated by a histidine-kinase sensor and a response regulator. Interestingly, the Bacteroidetes encode this system in a single polypeptide that can be delineated into a …
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Insights into the evolution of protein domains give rise to improvements of function prediction
… to analyse the function and evolution of protein domains in order to understand molecular processes in the cell. The focus was on signalling domains of little understood function, as well as on functional sites of protein domains in general. Glucosaminidases (GlcNAcases) represent key enzymes in …
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Non-canonical sensing mechanisms in bacteria
… Additionally, bacteria have evolved chemosensory navigation machineries to sense chemicals around them and move towards nutrient-rich regions or away from toxins in the process known as chemotaxis. Chemotaxis has been extensively investigated in number of bacterial species, such as …