Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 124 for “"Sensitisation"”.
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ATP, TRP channels and airway neuronal sensitisation
Cough is a productive reflex controlled by airway nerves which is respiratory conditions such as chronic obstructive pulmonary disease (COPD), becomes hyperresponsive contributing to the clinical problem of chronic cough. This project was focused on gaining a deeper understanding of the roles of …
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Putative changes in dopaminergic neurotransmission following nicotine induced behavioural sensitisation
Behavioural sensitisation is a progressive enhancement of stereotypic or locomotor behaviour following repeated intermittent administration of a psychostimulant or stress. It is a phenomenon thought to underlie many neuropsychiatric disorders (e.g. schizophrenia, addiction, depressive disorders, …
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Mechanisms of synovial fluid lipid-mediated neuronal sensitisation in arthritis
Arthritis affects millions of people and costs billions to the global economy. Although joint pain is the leading patient-reported symptom of those with arthritis, current analgesics often fail to produce consistent pain relief and, with chronic use, are associated with detrimental side effects. …
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Does distress predict central sensitisation in people living with HIV?
… health in many people with HIV (PWH). Central sensitisation (CS) is a hallmark of most persistent pain conditions. Pain and psychosocial distress (PSD) appear to have a bidirectional relationship. Therefore, it is plausible that PSD contributes to pain by increasing central sensitisation (CS), …
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The relative effectiveness of different forms of microteaching incorporating a sensitisation approach
… The microteaching courses incorporated a sensitisation, rather than a skills-training, approach and emphasised the usefulness of various questioning strategies and the development of sensitive and flexible control of a repertoire of questioning skills. The subjects were 96 student teachers …
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The relationship between immunization and food allergy and sensitisation in South African children
… effect of vaccinations on food allergy and food sensitisation varies. Therefore, the aim of this study is to determine if a relationship exists between vaccinations and food allergies and food sensitisation in children in the first 18 months of life who live in urban Cape Town and in rural …
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Genetic and environmental influences on cord blood atopic markers and on atopic sensitisation in infancy
… "at risk" for atopic disease is essential, since sensitisation begins at birth, or even during intra-uterine life. European and Scandinavian studies have shown that a raised concentration of cord blood serum immunoglobulin E (CBsIgE) is an excellent predictive marker for the subsequent development …
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The prevalence and patterns of IgE-mediated food allergy and sensitisation in South African children with atopic dermatitis
… the dermatology clinic. They were assessed for sensitisation and allergy by questionnaire, skin prick tests (SPT), Immuno Solid Phase Allergen Chip (ISAC) test and incremental food challenges. Sensitised patients were also tested for specific IgE by ImmunoCAP test. Results: One hundred …
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Predictors of occupational sensitisation to grain dust allergens and changes in lung function among grain mill workers in Cape Town
… was to identify the predictors of occupational sensitisation to grain dust allergens and changes in lung function among grain mill workers in Cape Town. There were two major objectives of the study. Firstly, to determine which of the following factors determine the distribution of serum ECP …
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A cross-sectional study of Ig-E mediated food sensitisation and food allergy in an unselected population of South African children aged 12-36 months
… participants and non-participants. We reported sensitisation pattern towards foods in the panel i.e. egg white extract, peanut, cow’s milk, wheat(flour), soy, hazelnut and fish (cod) according to the SPT categories. The effects of age, ethnicity, sex and concomitant allergy on sensitisation …
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The influence of socio-economic status on the prevalence of food sensitisation and food allergy in children 12 to 36 months in urban Cape Town, South Africa
… study is a sub-study of the South African Food sensitisation and Food Allergy (SAFFA) study, an on-going cross-sectional, observational study of IgE-mediated food allergy in an unselected population of children aged 12-36 months. The aim is to explore the influence of SES on food sensitisation …
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The study of occupational risk factors and interventions for baker's allergy and asthma among supermarket bakery workers
… bakery workers. It is caused by IgE-mediated sensitisation and subsequent allergic reaction in the airways to specific occupational airborne allergens in flour or baking ingredients. Major aims of this study were to: characterise asthma phenotypes and environmental exposure to flour allergens …
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Mechanisms Underlying Mesenchymal Stem Cell-Derived Extracellular Vesicle Modulation of Sensory Neuron Excitability
… further showed that MSC-EVs can directly inhibit sensitisation of dorsal root ganglion (DRG) neurons induced by nerve growth factor (NGF), a key mediator implicated in OA pathogenesis and associated pain. The present study sought to elucidate the mechanisms by which MSC-EVs prevent NGF-induced …
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Investigation of immune responses in different mouse models of allergic asthma
… development of effective therapies. The route of sensitisation to allergens is one factor that influences the immune response and the outcome of allergic diseases and both human and animal studies have highlighted IL-4Ra as an important component in the induction of allergy. The aim of this study …
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The role of constituency Offices in enhancing democracy and communication between members of parliament and their electorates: The case of Kabwata Constituency
… this could be attributed to the lack of adequate sensitisation programmes on the existence and purpose of the office. The study revealed that more still needs to be done if the offices are to fully serve their intended purpose. The study further revealed that there was need to engage the people so …
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The role of constituency Offices in enhancing democracy and communication between members of parliament and their electorates: The case of Kabwata Constituency
… this could be attributed to the lack of adequate sensitisation programmes on the existence and purpose of the office. The study revealed that more still needs to be done if the offices are to fully serve their intended purpose. The study further revealed that there was need to engage the people so …
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Modulation of the sensitivity of nociceptive neurones by cannabinoids and SNSR
… cyclase, the activation of which leads to the sensitisation of nociceptors, calcium imaging was used to assess if the application of a synthetic cannabinoid agonist (WIN 55,212-2) would attenuate the responsiveness of nociceptors in vitro. After examining this in both a nonsensitised model and …
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Allergic sensitization and work related asthma among poultry workers in South Africa
… the risk factors associated with allergic sensitisation and various asthma phenotypes in poultry workers. Methods: A cross-sectional study of 230 currently employed poultry workers used a modified ECRHS questionnaire, spirometry, fractional exhaled nitric oxide, Phadiatop and ImmunoCAP for …
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Improving the dietary management of orofacial granulomatosis
… a recent study identified a high rate of pollen sensitisation to pollens associated with oral allergy syndrome (OAS). OAS is an allergic disorder manifesting immediate lip swelling readily resolved by dietary avoidance of raw plant foods containing homologous proteins that cross react with these …
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