Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Senile dementia"”.
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Subtyping patients with Senile Dementia of the Alzheimer type using cluster analysis
… determine if distinct subgroups of patients with Senile Dementia of the Alzheimer Type (SDAT) could be identified using seven scales of the Cognitive Behavior Rating Scale (CBRS). Ward's method of cluster analysis was used to group 104 patients with a probable diagnosis of SDAT into subtypes.The …
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Spatially resolved light propagation in tissue-like media
… disease is one of the most common forms of senile dementia occurring in the elderly population, and at present has no cure. The first step in developing a monitoring instrument involves differentiating the optical properties of tissue. In this body of work, a protocol and algorithm for …
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Some aspects of biochemistry of fibrous proteins in brain
… that forms the neurofibrillary tangles in presenile and senile dementia. Suggestions are made about the nature and origin of these diseases. Some observations are also made about the protein skeletin, but because isolation and characterization methods currently available give conflicting …
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Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention
Alzheimer's disease is the leading cause of senile dementia in the elderly, and as life expectancy increases across the globe, incidence of the disease is continually increasing. Current estimates place the number of cases at 25-30 million worldwide, with more than 5.4 million of these occurring in …
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Kinetic modeling of amyloid fibrillation and synaptic plasticity as memory loss and formation mechanisms
… memory. Claimed to be the number one cause of senile dementia, Alzheimer's disease (AD) is one of the disorders that involve misfolding of amyloid protein and formation of insoluble fibrils. Although a variety of time dependent fibrillation data in vitro are available, few mechanistic models …
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Carers of the dementing elderly coping techniques and expressed emotion.
The focus of this thesis was the disease senile dementia and in particular the impact that this condition has on the family carers of elderly people with dementia who live in the community. The study has two main aims. Primarily it set out to identify the stressful situations which carers were …
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Dihydropteridine Reductase from Man and the Rat
… lobe samples from patients suffering from senile dementia of the Alzheimer type as compared to age matched controls, but this elevation was not significant. Dihydropteridine reductase activity was measured in several human brain regions.
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Tetrahydrobiopterin Metabolism in Mental Retardation
… and high neopterin-biopterin ratio was noted in senile dementia brains. Down's syndrome patients showed low plasma neopterin indicating a possible synthesis defect. Acute lymphoblastic leukaemia children on methotrexate showed elevated urinary biopterin excretion whilst fragile-X patients showed …
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Iron Dysregulation and Inflammation in Alzheimer’s Disease
… disease (AD) is the most common form of senile dementia in the US and worldwide but the causes of its pathogenesis are currently unknown. In this study, we examined two processes that have been implicated in the early stages of AD and other forms of neurodegeneration, iron dysregulation …