Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Semiflexible"”.
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Conformations of semiflexible polymers and filaments
… function and the technological applications of semiflexible polymers, such as DNA, actin filaments and carbon nanotubes, strongly depend on their rigidity. Semiflexible polymers are characterized by their persistence length, the definition of which is the subject of the first part of this …
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Force-response statistics of semiflexible polymers
… relations, bond correlations, and dynamics of semiflexible biopolymers. Despite these successes, the effects of non-uniform forces are not well understood. Examples include force-extension experiments of charged polymers under electric fields, or deformation forces in the actomyosin cortex …
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Translocation of a Semiflexible Polymer Through a Nanopore
… the dynamics of driven translocation of a semiflexible polymer through a nanopore in two dimensions (2D) using Langevin dynamics (LD) simulation. By carrying out extensive simulation as a function of different parameters such as, driving force, length and rigidity of the chain, viscosity of …
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Buckling instabilities of semiflexible filaments in biological systems
… des Zytoskeletts transportieren. Filamente sind semiflexible Polymere, deren Biegeenergie ähnlich groß ist wie die thermische Energie, so dass sie auch als elastische Balken auf der Nanoskala gesehen werden können, die signifikante thermische Fluktuationen zeigen. Wie ein makroskopischer …
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Computational studies of semiflexible polymer translocation in nanopore systems
… flexible, and the translocation dynamics of semiflexible molecules are not very well understood. In this thesis, in a set of articles, several aspects of translocation with semiflexible polymers in various nanopore systems are explored using molecular dynamics simulations. We look at the …
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Dynamics of single semiflexible filaments in a viscous fluid
Numerous cellular functions rely on semiflexible filaments as structural elements (F-actin, microtubules), locomotive organs (flagella, cilia) or carriers of information (DNA). Flexible and semiflexible polymers are also commonly encountered in technological applications, specifically in chemical …
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Interplay of flow and microstructure in complex fluids: Semiflexible polymer solutions and emulsions
… presented for Brownian dynamics simulations of semiflexible bead-rod chains with configuration-dependent anisotropic bead friction tensor. The algorithm for the dynamics and the stress generalizes an earlier one restricted to isotropic, configuration-independent friction (Grassia and Hinch …
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Conformation and Rheology of Semiflexible Macromolecules Using Non-Equilibrium Brownian Dynamics and Monte Carlo Simulations
Non-Equilibrium Brownian Dynamics Simulations (NEBD) and Configuration-Biased Monte Carlo (CBMC) methods are used to model the dynamics of semi-flexible macromolecules and polyelectrolytes undergoing shear and extensional flow. The mathematical model utilizes a discretized version of the …
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Interplay of Geometry and Mechanics: Disordered Spring Networks and Shape-changing Cerebella
… strain-induced stiffening transitions in semiflexible networks with area-conserving inclusions and III) non-linearities in the buckling without bending morphogenesis model for growing cerebella. All models are two dimensional and we employ either discrete and continuum models to study …
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Theoretical and Experimental Studies of Structure Formation in Polymer Solutions Under Flow
… as equivalent to that of a model system of semiflexible macromolecules in the absence of applied forces. Application of equilibrium conditions results in model predictions which are in good agreement with experimental observations i.e., changes in the binodal curve, increase in the amount of …
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Single stranded DNA: A new model system for single molecule polymer dynamics
… non-equilibrium conditions. However, dsDNA is a semiflexible polymer with markedly different local molecular properties compared to flexible polymer chains, such as synthetic organic polymers. In this work, we developed a new model system for single molecule studies of flexible polymers based on …
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Theoretical study of single-molecule spectroscopy and vibrational spectroscopy in condensed phases
… in the conformational fluctuations. A semiflexible Gaussian chain model is used to determine the statistics and correlations of single-molecule fluorescence resonant energy transfer (FRET) experiments on biological polymers. The distribution functions of the fluorescence lifetime and …
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Investigation of biopolymer properties with combined fluorescence correlation spectroscopic and computational methods
… zeigt, dass sich Polythymine wie semiflexible Polmere verhalten, dass für Kettenmoleküle mit einer Länge von N > 30 der Einfluss der Farbstoffmarkierung vernachlässigbar ist und dass elektrostatische Wechselwirkungen bei einer Natriumchlorid-Konzentration von 100 mM vollständig …
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Microstructurally-based constitutive models of cytoskeletal networks for simulation of the biomechanical response of biological cells
… the MacKintosh worm-like chain relationship for semiflexible filaments. The filament expression is used in the Arruda-Boyce eight-chain network model to capture the 3D stress-strain behavior, quantifying the effects of isotropic network prestress and tracking microstructural stretch and …
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Biology's wires and motors : single-molecule mechanics of M13 bacteriophage and kinesin
… length (1265 nm) that places it squarely in the semiflexible polymer regime. Single-molecule stretching also revealed a mechanically robust and genetically versatile tether that could serve as a general "molecular handle" for single-molecule biophysics. As such, M13 was further engineered to …
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Mechanics of biopolymer networks, stimuli responsive particle suspensions, and their combinations
… stiffens under the stress owing to its semiflexible nature. This helps achieve a higher sensitivity to the external field in the fabricated composites compared to the traditional flexible-polymer matrix of composite systems. Phenomenological models are developed that quantify this …
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Single molecule studies of flexible polymer systems
… non-equilibrium conditions; however, dsDNA is a semiflexible polymer with markedly different local molecular properties compared to flexible polymer chains, such as synthetic organic polymers. This thesis presents a new methodology for studying truly flexible polymers at the single molecule …
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Cationic Polymers and Polymeric Micelles as Plasmid DNA and CRISPR-Cas9 Ribonucleoprotein Delivery Vehicles
… inherent structural differences between long, semiflexible DNA and globular RNA-protein payload. Herein, several classes of polymeric delivery vehicles were synthesized and investigated, namely, cationic linear polymers, block copolymers, and polymeric micelles. Initially, a systematic …
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Coarse-grained simulations to predict structure and properties of polymer nanocomposites
… approach to discern how the concentration of a semiflexible polymer, its rigidity and the particle's size determine the interfacial layer thickness, and the scaling laws to describe this dependency. We also utilize molecular dynamics and simulation techniques on a model PNC to determine if the …
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Direct imaging of single-walled carbon nanotubes reptational dynamics in packed-colloid porous media
… and transport of intrinsically fluorescent, semiflexible, semiconducting single-walled carbon nanotubes (SWCNT) in the sub-micron pores of randomly packed colloids as fixed obstacles of packed-colloid porous media. In packed-colloid pores, we find SWCNTs diffuse along straight pores and bend …
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