Global ETD Search
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Showing 1 to 5 of 5 for “"Semaphorin3A"”.
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Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
During development, neurons extend long axons which must navigate towards specific synaptic targets in the brain. This navigation is accomplished by a sensorimotor apparatus called the neuronal growth cone, located at the tip of the growing axon. Growth cones rely on signals present in their …
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The mechanical regulation of Semaphorin3A signalling in the developing Xenopus laevis brain
… to the classical repulsive chemical guidance cue Semaphorin3A is regulated by substrate stiffness. The strength of axonal turning responses to Semaphorin3A can be quantified using a turning assay, whereby axons change their trajectory in response to a gradient of a chemical cue. I developed two …
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Interplay between Piezo1-mediated mechanosensing and the chemical guidance cue Semaphorin3A during development of the embryonic nervous system
… of Piezo1 dramatically altered the expression of semaphorin3A mRNA (sema3A), a chemical guidance cue known to be critical in axon pathfinding. Thus, both chemical and mechanical signals encountered by the axons were altered when Piezo1 was less abundant in the brain. To determine if tissue …
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Neuronal filopodia borne along tips and shafts of dendrites comprise two distinct populations as evidenced by differences in structure and dynamics
… responses to developmental cues, specifically, Semaphorin3A (Sema3A). Using confocal microscopy to visualize filopodial membrane and actin we found that shaft filopodia are shorter than tip filopodia, and show a less dense presentation along the dendrite. We then employed the quantitative phase …
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The role of tissue viscoelasticity in axon guidance during Xenopus brain development
… to gradients of the chemical guidance cues Semaphorin3A, Slit 1 and Slit 2 as well as tissue elasticity. However, while the importance of elasticity is becoming well-accepted in the context of development, biological tissues are not purely elastic but rather exhibit time-dependent mechanical …