Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Semaphorin 3A"”.
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Redox manipulation alters hippocampal neuron response to semaphorin 3A
… These cues include the secreted protein known as semaphorin 3a (Sema3A) and various redox reactions such as the oxidizing function of Mical proteins on f-actin that function downstream of Sema3A. However, what is less understood is how various redox conditions alter these guiding cues. This work …
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The role of semaphorin 3A signaling underlying learning and memory formation in the postnatal mouse brain
… molecular pathways remain less well understood. Semaphorins are a family of secreted and membrane-bound guidance cue proteins originally identified in the developing nervous system through their chemorepulsive action at growth cones. Growth cones are actin-rich structures found at the tips of …
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Repulsive cues and signalling cascades of the axon growth cone
… the conflicting data in the literature on Semaphorin-3A signalling, where differing labs had shown that inhibiting protein synthesis either blocks or has no effect upon repulsion. They demonstrate the presence of at least two independent pathways, protein synthesisdependent mTOR activation …
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Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
… (type I hemidesmosomes and the perlecan-semaphorin 3A-plexin A1-neuropilin-1 (PSPN) complex) and translates this knowledge into viable solutions for both tissue engineering and cancer metastasis applications. Database (Matrisome/FANTOM5) and two-dimensional and three-dimensional cell …
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Piezo1-dependent mechanical regulation of chemical signalling in the developing Xenopus laevis brain
… signals. Major chemical signals include semaphorins, slits, netrins and ephrins/Eph, whereas mechanical signals include tissue stiffness, viscosity and cellular forces. In the developing embryo, chemical and mechanical signals are not isolated. However, how cells integrate these two …
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The Molecular Regulation of Spinal Nerve Outgrowth
… an interaction with the axon growth repellent Semaphorin 3A. Then I looked at the expression of Fibulin-2 in two models of CNS injury: mouse cerebral cortical stab injury and rat dorsal crush spinal cord injury. In both cases, I observed an increase in Fibulin-2 protein level compared to …
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Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
… environment of neurons impacts their response to Semaphorin 3A (Sema3A), a highly conserved guidance molecule that classically functions as a chemorepellant in this system. Indeed, I found that the response of Xenopus RGC growth cones to Sema3A was significantly reduced on softer substrates. This …
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The Role of Twist2 in Physiologic and Pathologic Myogenesis
The file named "LI-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.