Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Semaphorin"”.
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Redox manipulation alters hippocampal neuron response to semaphorin 3A
… These cues include the secreted protein known as semaphorin 3a (Sema3A) and various redox reactions such as the oxidizing function of Mical proteins on f-actin that function downstream of Sema3A. However, what is less understood is how various redox conditions alter these guiding cues. This work …
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Characterizing New Molecules and Mechanisms of Semaphorin/Plexin/MICAL Signaling
… of extracellular guidance cues, members of the Semaphorin family of proteins, induces actin cytoskeletal changes. Interestingly, Semaphorins have been found to inhibit the movement of cells and their membranous processes but the molecules linking them to these specific behaviors have remained …
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The Role of Semaphorin-Neuropilin-1 Signalling in Pulmonary Vascular Development
… endothelial growth factor (VEGF) and Class 3 Semaphorins (SEMA3). Although VEGF-NRP1 interactions in systemic vascular development have been described, the importance of SEMA3-NRP1 signalling in systemic or pulmonary vascular morphogenesis is uncertain. We hypothesized that SEMA3-NRP1 and …
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Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
The Semaphorin-Plexin signaling is important for regulating axon guidance. Binding of Semaphorin to the Plexin receptor induces the dimerization of Plexin and stimulates its cytoplasmic GAP activity towards Rap, resulting in cytoskeleton re-organization. The growth cone of an axon then turns …
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The role of semaphorin 3A signaling underlying learning and memory formation in the postnatal mouse brain
… molecular pathways remain less well understood. Semaphorins are a family of secreted and membrane-bound guidance cue proteins originally identified in the developing nervous system through their chemorepulsive action at growth cones. Growth cones are actin-rich structures found at the tips of …
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Effekte der Klasse-3 Semaphorine auf die Entwicklung und Progression maligner Hirntumoren
… Faktoren der Axon-Orientierung aus der Klasse-3-Semaphorin-Subfamilie eine Rolle. Kürzlich konnte gezeigt werden, dass Semaphorin-3F (s3f), welches zu den Klasse-3-Semaphorinen zählt, die Tumorgefäßentwicklung hemmt. S3f und andere Klasse-3-Semaphorine wie Semaphorin-3B (s3b) wirken als direkte …
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Repulsive cues and signalling cascades of the axon growth cone
… the conflicting data in the literature on Semaphorin-3A signalling, where differing labs had shown that inhibiting protein synthesis either blocks or has no effect upon repulsion. They demonstrate the presence of at least two independent pathways, protein synthesisdependent mTOR activation …
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… elongation, navigation, and connectivity. Semaphorins, for example, are one of the largest families of these guidance signals and play critical roles in neurobiology, angiogenesis, immunology, and cancer. One interesting characteristic of the Semaphorins is that they inhibit the movement of …
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… elongation, navigation, and connectivity. Semaphorins, for example, are one of the largest families of these guidance signals and play critical roles in neurobiology, angiogenesis, immunology, and cancer. One interesting characteristic of the Semaphorins is that they inhibit the movement of …
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Sema-1a Reverse Signaling Promotes Midline Crossing In Response To Secreted Semaphorins
… are enhanced by mutations in the transmembrane semaphorin, Sema-1a. Mutations in sema-1a also dominantly enhance crossing defects in a netrin mutant, indicating that Sema-1a functions in a Netrin independent pathway to promote midline crossing. Here we identify the transmembrane Semaphorin, …
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Regulation of Mical Redox Post-Translationally-Driven F-Actin Cytoskeletal Dynamics
… of extracellular repulsive guidance cues, the Semaphorins, which were identified in part based on their ability to dramatically dismantle F-actin. More recently, we identified a new actin regulatory protein Mical, which directly associates with both the Semaphorin receptor Plexin and F-actin to …
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Plxna4 and its role in neuronal survival in the developing zebrafish hindbrain
… are a family of transmembrane proteins that bind Semaphorin ligands, and are known to function in axon guidance. In embryonic zebrafish, I find that plxna4 is expressed widely in the nervous system early in development, and localizes to the hindbrain as neurogenesis and differentiation proceed. In …
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Inhibition of Retinoic Acid Receptors Results in Defasciculation of the Trigeminal Nerve in Xenopus laevis
… leukocyte cell adhesion molecule (ALCAM) and Semaphorin 4B (Sema4B). We have analyzed the expression patterns of Sema4B and NT-3 by in situ hybridization and have found NT-3 expression in the eye and Sema4B in the embryonic target of the trigeminal nerve, lens of the eye and in the pharyngeal …
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Neural Stem Cells as a Model to Study Huntington’s Disease
… the downstream signaling components of Plexin/Semaphorin pathway of the neurons. Our work began with optimization of the growth conditions of the cell lines of our model cell system. We then focused on developing protocols for differentiation into neurons, and continued with immunocytochemistry …
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Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
… (type I hemidesmosomes and the perlecan-semaphorin 3A-plexin A1-neuropilin-1 (PSPN) complex) and translates this knowledge into viable solutions for both tissue engineering and cancer metastasis applications. Database (Matrisome/FANTOM5) and two-dimensional and three-dimensional cell …
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Halting the neural progression of cancer
… axonal guidance and neuronal patterning. Class 3 semaphorin (SEMA3) molecules act as inhibitors of NRP receptors by preventing the activation of downstream signaling pathways involved in cytoskeletal organization and migration. Tumor-associated axonogenesis, defined as the growth of neuronal axons …
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Piezo1-dependent mechanical regulation of chemical signalling in the developing Xenopus laevis brain
… signals. Major chemical signals include semaphorins, slits, netrins and ephrins/Eph, whereas mechanical signals include tissue stiffness, viscosity and cellular forces. In the developing embryo, chemical and mechanical signals are not isolated. However, how cells integrate these two …
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The Role of BMP9-Induced SEMA3G in Pulmonary Vascular Stability
… cells after treatment with BMP9 revealed Semaphorin 3G (SEMA3G) as a potential BMP9-regulated gene. Class 3 semaphorins have been implicated in angiogenesis and endothelial cell migration, with several family members, including SEMA3G, inhibiting VEGF signalling via competition for the …
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The Molecular Regulation of Spinal Nerve Outgrowth
… an interaction with the axon growth repellent Semaphorin 3A. Then I looked at the expression of Fibulin-2 in two models of CNS injury: mouse cerebral cortical stab injury and rat dorsal crush spinal cord injury. In both cases, I observed an increase in Fibulin-2 protein level compared to …
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Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
… environment of neurons impacts their response to Semaphorin 3A (Sema3A), a highly conserved guidance molecule that classically functions as a chemorepellant in this system. Indeed, I found that the response of Xenopus RGC growth cones to Sema3A was significantly reduced on softer substrates. This …
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