Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Self-immolative linkers"”.
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Development of Novel Self-Immolative Linkers based on Fragmentation and Cyclisation Reactions for Targeted Therapeutic Applications
La terapia dirigida se ha erigido a lo largo de los últimos años como una de las estrategias más prometedoras para el tratamiento del cáncer. Estos sistemas consisten en una molécula con una alta afinidad y selectividad hacia una diana presente en células cancerosas, conjugada a fármacos …
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Synthesis of diene ligands with H-bonding capabilities for bioimaging applications
… investigated. The synthesis of bioprobes with self-immolative linkers that also contain both fluorophores and tricarbonyliron complexes and a study of their enzymatic cleavage reactions is also described. The reaction of an electrophilic cyclohexadienyliron(1+) complex with …
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Design of smart linkers and their applications in controlled-release drug delivery systems
… drug conjugates (SMDC). We have prepared acetal linkers featuring coumarin as fluorophore and a duocarmycin analogue as an example of cytotoxic drug. Markedly, it represents the first example a duocarmycin analogue is protected with an acid cleavable moiety. Kinetic studies were performed on …