Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Self-cleavage"”.
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Computational studies of the self-cleavage mechanism in the glmS ribozyme
… (GlcN6P) in bacteria by catalyzing a self-cleavage reaction. Namely, the GlcN6P bonds to the glmS ribozyme and triggers a cleavage of a phosphodiester bond at a certain position via a general acid-base mechanism. This work explored the following aspects of its self-cleavage mechanism: …
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Computational studies of the structure, dynamics, and catalysis of the hepatitis delta virus ribozyme
… nucleolytic RNA that performs a phosphodiester self-cleavage reaction generating products with a 2’, 3’-cyclic phosphate and a 5’ -hydroxyl termini. This ribozyme was initially discovered in the RNA genome of the human pathogen HDV, where it played a crucial role in the viral life cycle, …
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STRUCTURAL AND FUNCTIONAL DETERMINANTS OF CASPASE-11 INFLAMMASOME ASSEMBLY DURING INNATE IMMUNE DEFENSE
… Casp11 catalytic activity and intra-molecular self-cleavage in noncanonical inflammasome assembly.
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Search for new types of deoxyribozymes and development of human topoisomerases inhibitors on the basis of oligonucleotides
… of new types of deoxyribozymes that possess DNA self-cleaving activity. Certain guanine-rich oligonucleotides with potential to form G-quadruplexes were constructed and their self-cleaving activities are examined during our investigations. Our studies demonstrated that certain guanine-rich …
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Co-ordinated expression of CRTB, At-VTE3, and VTE4 to enhance pro-vitamin A and vitamin E in transgenic soybean
… (VTE4) to increase [alpha]-tocopherol using the self-cleavage activity of FMDV 2A sequence to join two adjacent proteins. This 2A-polyprotein construct was introduced to soybean via Agrobacteriummediated cotyledonary node transformation method. One inheritable transgenic event displayed …
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Ghrelin Processing and Maturation: Developing a Molecular-Level Framework for Hormone Activation and Biological Function
… and C-ghrelin, as well as an unidentified self-cleavage behavior which has implications in hormone maturation. In complementary studies to characterize ghrelin binding to GOAT, ghrelin peptide mimetics incorporating an amine-substituted Dap residue at the site of acylation provided a …
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Structural and Biochemical Characterization of N-Terminal Protease of Classical Swine Fever Virus
… cysteine protease family C53. After the initial self-cleavage, Npro is no longer active as a protease and no trans activity has ever been observed. Npro also plays a critical role in subverting the host’s innate immune response by targeting interferon regulatory factor-3 (IRF3) for proteasomal …
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INTEGRATED MOLECULAR INVESTIGATIONS OF MYRF AND SFRP2: UNVEILING REGULATORY MECHANISMS OF ER STRESS AND ECM REMODELLING IN PANCREATIC CANCER
… glandular cells. After trimerization and self-cleavage, MYRF releases the N-terminal fragment which translocates into the nucleus to exert its transcriptional role by regulating the expression of genes encoding secretory proteins. However, the role of C-terminal fragment which remains …
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DNA catalysts for amide bond cleavage and for lysine side chain modification
… be extensive. Protease enzymes, which catalyze cleavage of proteins, are essential enzymes for biotechnology. Engineering of natural proteases to change their site of cleavage is an exciting prospect, but this process usually leads to relaxed substrate selectivity, rather than a true change in …