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Showing 1 to 19 of 19 for “"Self-assembling peptides"”.
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Pro-Angiogenic Self-Assembling Peptides
Peptide amphiphiles (PAs), peptides that self-assemble into hydrogels with a nanofibrous network, are interesting biomaterials due to their biocompatibility and biodegradability. Self-assembling peptide-based materials include a wide range of peptide motifs that form one-dimensional nanostructures …
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Modeling of Therapeutic Drugs, Polymers, and Self-Assembling Peptides
… drugs and therapeutic polymers, B) therapeutic peptides, and C) materials based on self-assembled peptides. A) We designed and investigated antivirals based on sulfoglycodendrimers and polystyrene sulfonate polymers of different topologies and sizes that can mimic heparan sulfate proteoglycans. …
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Nanofiber characterization of self-assembling peptides RAD16 and RID 12
Self-assembling peptides are quickly proving themselves useful in tissue engineering and most recently, electronics. Self-assembling peptides have been shown to form a network of nanofibers that can be used in scaffold research or as templates for nanowires. However, self-assembling peptides have …
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Regulating the Biomedical and Biocatalytic Properties of Amphiphilic Self-assembling Peptides via Supramolecular Nanostructures
Self-assembly is a fundamental process in the field of nanotechnology, where molecules organize into complex structures spontaneously or induced by environmental factors. Peptides, short chains of amino acids, can self-assemble into many types of nanostructures. The self-assembly of peptides is …
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Composition, thermodynamics, and morphology: A multi-scale computational approach for the design of self-assembling peptides
Peptide self-assembly has generated significant interest as a means for the bottom-up fabrication of highly tunable biocompatible nanoaggregates. Individual peptides can be synthesized to include non-natural π-conjugated subunits, endowing assembled aggregates with a range of optical and electronic …
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Studies fo the microstructure of self-assembling peptides : effects of chemical cross-linking and growth characterization
… because it has known to be capable of self-assembly. Also, the peptide scaffolds can support neuronal cell attachment, differentiation, and neuron outgrowth. They might therefore p lay a role as substrate for functional synapse formation between neurons. One important feature of peptide …
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Characterization of self-assembling peptide nanofibers of KLD12 and RID 12
Self-assembling peptides are a promising new area of research with usage in numerous areas, from tissue engineering to membrane protein biology. This work is to further study the characteristics of the peptides KLD12 and RID12 and to generate new ways to control the properties of them. Peptide …
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Developing osteoarthritis treatments through cartilage tissue engineering and molecular imaging
… the value of potential therapies. Agarose and self-assembling peptides have been used to make hydrogels for in vitro culture of bovine bone marrow stromal cells (BMSCs) which can differentiate into chondrocytes, undergo chondrogenesis, and produce cartilage tissue. So far, differences in cell …
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Optimized Peptide Nanomaterials as Delivery Vehicles for Hydrophobic Metal-Based Anticancer Agents
… In this thesis we demonstrate that anionic self-assembling peptides can be utilized as delivery vehicles for metal-based hydrophobic payloads. The tunability of the system is highlighted as well as the increase in cytotoxicity and selectivity in vitro. The rapid degradation of peptides in …
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The effect of dynamic shear force on chondrocyte biosynthesis in agarose gels
… as well as in hydrogels such as agarose and self-assembling peptides. Also, recent research has revealed that biosynthesis in cartilage explants can be increased by dynamic tissue shear loading as well. Thus, the purpose of this study was to investigate whether dynamic tissue shear loading …
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Self-assembling amphiphilic peptides: A novel approach to create new drug systems and three-dimensional scaffolds for tissue regeneration. A resourceful mine not yet fully explored
Molecular self-assembly offers unique features for the development of novel supramolecular structures and advanced materials. The inspiration for the creation of these complex structures is often driven by nature, where complex architectures are obtained from simple building block such as amino …
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Strategies to design and optimize natural polymers as biomaterial inks for musculoskeletal tissue engineering applications
… blending with hyaluronic acid, use of ultrashort self-assembling peptides and incorporation of inorganic fillers. Moreover, the biological outcomes of the scaffolds were tuned with the addition of different bioactive cues (i.e. tropoelastin or bioceramics) providing a versatile platform for the …
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Mechanical behavior and microstructure of self-assembling oligopeptide gels
… class of hydrogel is formed from synthetic oligopeptides that self-assemble into a solution of beta-sheet filaments. These filaments can aggregate to form a gel suitable for culture of various cell types. Examples of such self-assembling peptides are RAD16-I, RAD16-II, and KLD-12. One limitation …
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Simultaneous, Large Multi-Gene Delivery for Implementation of Fluorescent Reporter Spatial Multiplexing to Image Signaling Pathways
… By fusing a fluorescent reporter to a pair of self-assembling peptides or a self-assembling RNA-protein pair, reporters could be stably clustered within cells at random points, distant enough to be resolved by a microscope, but close enough to spatially sample the relevant biology. These …
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Modulation of Immunity via Antibodies Displayed on in situ Forming Peptide Co-assemblies
… co-assemblies and two linker proteins. The self-assembling peptides EAK16-II and EAKIIH6 co-assemble into fibrous structures with accessible His-tags when exposed to salts. Anti-His-tag antibodies (αH6-IgG) bind to these His-tags and provide fragment crystallizable region (Fc) for protein …
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Studio di biomateriali usati come scaffold per Tissue Engineering e loro caratterizzazione con tecniche spettroscopiche vibrazionali e di analisi termica
… surface modification with synthetic oligopeptides that elicit the interaction with osteoblasts. The characterization of the PCL-PLLA composite underlined that the degradation started along PLLA fibres, which are more hydrophylic, and they serve as a guide for tissue regeneration. Moreover …
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Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
… CD8+ T cell responses. We recently reported that self-assembling peptides that assemble into β-sheet rich nanofibers in physiological buffers could act as self-adjuvanting vaccine carriers. Nanofibers bearing an antigenic peptide epitope from chicken egg ovalbumin (OVA323-339) elicited strong CD4+ …
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A Peptide-Based Platform for Displaying Antibodies to Engage T Cells
… vivo. The composite consists of two amphiphilic peptides, AEAEAKAKAEAEAKAK (referred to as "EAK") and AEAEAKAKAEAEAKAKHHHHHH ("EAKH6"). Spectroscopic analysis showed the two peptides integrated into a single structure. Prior to combination, conformational analysis revealed that EAKH6 adopts a …
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Self-Assembling Bioaffinity Hydrogels for Localized Antibody Delivery
… (irAEs). Loss of immunological tolerance to self-antigens or increased susceptibility to infections have been documented in some mAb treatments. Localized sustained release of mAb at disease sites might mitigate the risk of such toxicities. Antibody drugs are formulated typically for …