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Showing 1 to 20 of 27 for “"Self-assembling peptide"”.
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Self-Assembling Peptide Nanofibers RADA16 and IEIK13 for Rapid Hemostasis
… stability, cost effective, and bioabsorbable. Self-assembling peptide nanofibers RADA16 and IEIK13 provide a unique possibility to create a hemostat that meets all of these criteria. These short peptides self-assemble into nanofibers that entangle and gel in solution. Through the use of …
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Characterization of self-assembling peptide nanofibers of KLD12 and RID 12
Self-assembling peptides are a promising new area of research with usage in numerous areas, from tissue engineering to membrane protein biology. This work is to further study the characteristics of the peptides KLD12 and RID12 and to generate new ways to control the properties of them. Peptide …
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A self-assembling peptide scaffold functionalized for use with neural stem cells
… of a biological scaffold formed by the self-assembling peptide RADA16 is comparable to the most commonly used synthetic materials employed in the culture of neural stem cells. Furthermore, improvements in the performance of RADA16 have recently been made by appending the self-assembling …
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Characterization of shear stiffness and cell metabolism in chondrocyte-sealed self-assembling peptide hydrogel scaffolds
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
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Design of a microreactor for studying the effect of shear stress on angiogenesis in self-assembling peptide matrix
… using a microfabricated substrate, a self-assembling peptide gel, and bovine aortic endothelial cells. A theoretical model was developed to approximate the permeability of the peptide gel and to quantify the average shear stress on an endothelial cell seeded in a 3D matrix of the …
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A novel osteochondral composite consisting of a self-assembling peptide hydrogel and 3D printed polycaprolactone scaffold : potential for articular cartilage repair
… a means of integrating a chondrocyte-seeded peptide hydrogel with an interconnected porous 3D printed polycaprolactone (PCL) scaffold to create a novel osteochondral construct. The self-assembling peptide hydrogel has been shown to provide an environment that maintains chondrocyte phenotype …
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In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds
The inability of articular cartilage to repair itself after acute injury has been implicated in the development of osteoarthritis. The objective of this work was to develop methods for delivering growth factors to cartilage and to test the ability of a self-assembling peptide scaffold, (KLDL)3, …
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Targeted Gene Therapy Approaches for Huntington's Disease: Advancing Treatment through Bioengineered Self-Assembling Peptide Hydrogels and BDNF-Encoded Adeno-Associated Viruses, Applied In Vitro and In Vivo
… and more efficient viral-based gene delivery. Self-assembling peptide (SAP) hydrogels are fabricated from detectable peptide sequences of tissue-specific ECM proteins to not only mimic native ECM biochemically but also provide nanofibrous structural support to enhance and control tissue …
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Targeted Gene Therapy Approaches for Huntington's Disease: Advancing Treatment through Bioengineered Self-Assembling Peptide Hydrogels and BDNF-Encoded Adeno-Associated Viruses, Applied In Vitro and In Vivo
… and more efficient viral-based gene delivery. Self-assembling peptide (SAP) hydrogels are fabricated from detectable peptide sequences of tissue-specific ECM proteins to not only mimic native ECM biochemically but also provide nanofibrous structural support to enhance and control tissue …
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Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery
… of this thesis was to advance the use of self-assembling peptide hydrogel scaffolds for cartilage repair by encapsulating bone-marrow-stromal cells (BMSCs) and incorporating chondrogenic cues to stimulate differentiation and neotissue production. To test the hypothesis that self-assembling …
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Mechanical behavior and microstructure of self-assembling oligopeptide gels
… class of hydrogel is formed from synthetic oligopeptides that self-assemble into a solution of beta-sheet filaments. These filaments can aggregate to form a gel suitable for culture of various cell types. Examples of such self-assembling peptides are RAD16-I, RAD16-II, and KLD-12. One limitation …
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Supporting bone regeneration: Evaluation of endocrine peptides and delivery systems for local application of lactoferrin
… to evaluate the myokine irisin and the neuropeptide orexin as potential bone anabolic factors and to develop a clinically suitable drug delivery system for the optimal delivery of the bone anabolic factor lactoferrin (LF). Methods We developed an ex vivo osteocyte culture system, and …
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Pro-Angiogenic Self-Assembling Peptides
Peptide amphiphiles (PAs), peptides that self-assemble into hydrogels with a nanofibrous network, are interesting biomaterials due to their biocompatibility and biodegradability. Self-assembling peptide-based materials include a wide range of peptide motifs that form one-dimensional nanostructures …
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A novel bioengineering platform using functionalized self-assembly peptides to enhance CYP3A2 activity in modified rat hepatocyte sandwich cultures
… modified sandwich cultures are substituted with self-assembling peptide, RAD16-I, combined with integrin-binding sequence RGD or laminin receptor binding sequence YIGSR functional peptide motifs to create a cell-instructive peptide scaffold. To facilitate oxygen and nutrient diffusion and …
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Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
… cancers. Subunit vaccines using whole protein or peptide epitopes are becoming increasingly favored due to their superior safety profile compared with live-attenuated or inactive pathogen formulations. The immunogenicity of subunit vaccines often depend heavily on adjuvants. Currently approved …
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Characterization and Implementation of Low Intensity Pulsed Ultrasound as a Tool to Apply Physical Load to Scaffolds and Bone Cells for Fracture Repair
… a load to a GFP-actin labeled macrophage and a self-assembling peptide hydrogel to model the ECM. Loading and deformation were visualized using 3D fluorescent deconvolution microscopy. Analysis of the deformation showed the matrix to have viscoelastic or elastic behavior when compressed, with …
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Efficacy of Curodont in Managing Incipient Caries in Primary Teeth
… Vanish 5% Sodium Fluoride White Varnish), and a self-assembling peptide (Curodont Repair) to remineralize incipient enamel caries lesions in primary teeth. Methods: Caries-free primary molars were sectioned into enamel specimens (n=32), inoculated with Streptococcus mutans, and subjected to …
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In vitro culture of a chondrocyte-seeded peptide hydrogel and the effects of dynamic compression
… three-dimensional geometry. In these studies, a self-assembling peptide hydrogel is evaluated as a potential scaffold for cartilage repair using a model bovine cell source. A seeding technique is developed for 3-D encapsulation of chondrocytes in a peptide hydrogel. The chondrocyte-seeded peptide …
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Single-dose growth factor treatments to enhance cell recruitment and neotissue integration in an augmented microfracture cartilage repair model
… by joint injury have a limited capacity to self-repair, and if left untreated, can lead to the early onset of osteoarthritis. The current gold standard of care, microfracture surgery, induces an endogenous repair response, but typically results in poorly integrated fibrocartilage, rather …
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Synthetic Functionalized Scaffolds for Culture and Maintenance of Primary Human Hepatocytes
… a supramolecular biomaterial out of simple peptide and saccharide building blocks to act as a hydrogel scaffold to support culture of liver cells. Using a self-‐assembling peptide fiber decorated with functional molecules, we were able to culture primary human hepatocytes demonstrate their …
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