Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Selenomethionine"”.
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The effects of dietary selenomethionine on the escape behaviours of Fathead Minnows
… In this thesis, I assessed the impacts of a selenomethionine-laden diet on the escape behaviours of the Fathead Minnow. Using kinematic analysis, I observed how fish responded to various looming threats. I exposed fish to sub-chronic periods of environmentally relevant concentrations of …
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The mechanism of action of the anticancer effects of selenomethionine on colon cancer
Selenomethionine, an organic derivative of selenium, has been found to be the predominate selenium component of the dietary cancer chemopreventive agent selenized yeast that has been shown to decrease the incidence and mortality rate of lung, colon, and prostate cancers. Another organic selenium …
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Interactive effects of selenium on arsenic and cadmium induced toxicity in rainbow trout (Oncorhynchus mykiss)
… hepatocytes in primary culture. Selenite and selenomethionine were used as the inorganic and organic chemical forms of selenium to understand the chemical species-dependent effects. Interactions at the organismal level were studied by feeding the fish with Artemia based diets supplemented with …
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Reactions of Platinum(II) Compounds with Selenium Containing Amino Acids
… of selenium containing amino acids including selenomethionine and selenocysteine, new research is ongoing to see what types of products can be formed from these amino acids. Our research reacts [Pt(Met-<em>S</em>,<em>N</em>)Cl<sub>2</sub>] <sup>2+</sup> with selenomethionine to determine what …
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X-ray diffraction analysis of gene V protein encoded by filamentous bacteriophage Ff
… multiwavelength anomalous diffraction on the selenomethionine-containing wild-type and isoleucine-47 $\to$ methionine mutant proteins with x-ray diffraction data phased to 2.5 A resolution. The structure of the wild-type protein was refined to an R factor of 19.1% using native data to 1.8 A …
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Selenium bioaccumulation and speciation in the benthic invertebrate Chironomus dilutus: an assessment of exposure pathways and bioavailability
… fraction of organic selenides, modeled as selenomethionine, in C. dilutus larvae and adults. Results from the 2008 in situ caging study confirmed that surface water is not a significant selenium exposure pathway for benthic invertebrates at Key Lake. Chironomus dilutus larvae accumulated …
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The design and structural characterization of oligomeric beta beta alpha mini-proteins
… or by the introduction of heavy atoms. Two selenomethionine mutants having solution-phase properties comparable to the native were identified. The structures of these two peptides were independently solved via MAD phasing experiments, and the refined structures employed as search models for …
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Crystallographic studies on enzymatic halogenation of natural products
… in syringomycin biosynthesis, were solved using selenomethionine labeling and single wavelength anomalous dispersion (SAD) techniques. These structures show an overall cupin or [beta]-sandwich fold and a novel iron binding motif containing a naturally occurring iron-chloride bond. The carboxylate …
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On The Development, Characterization, And Use Of Protein Fluorescence And Infrared Spectroscopic Probes
… we show that (1) p-cyanophenylalanine and selenomethionine constitute an efficient fluorophore-quencher pair, useful for characterizing protein conformational changes that occur on a short distance; (2) 4-cyanotryptophan is a novel blue fluorescent amino acid, applicable for biological …
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Exploring combined effects of arsenic and selenium exposure on larval zebrafish (Danio rerio)
… (as selenite), and As 120 μg/L + Se 2.5 μg/L (as selenomethionine, SeMet) until 4 days post-fertilization. There was no significant difference in the survival, hatching and deformity rate when fish were exposed to both As and Se. Co-exposure to As and Se significantly affected thigmotactic …
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The development of methods for the determination of selenium using spectrofluorimetric and ICP-MS techniques.
… a developed method in which the selenium species selenomethionine, Se (IV), and Se (VI) were extracted, separated by HPLC prior to on-line photoreduction of Se (VI), and post column hydride generation before ICP-MS detection. Separation of the three species was achieved with excellent resolution …
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Selenotrisulfide Derivative Of Alpha-lipoic Acid: Evaluation In A Cell Culture Model For Potential Use As A Topical Antioxidant
… a supplement in cell culture than selenate or L-selenomethionine, two forms of selenium commonly used as supplements. LASe was also found to protect HaCaT keratinocytes from UV- induced cytotoxicity. Cells pretreated with LASe and exposed to 500J/m2 and 750J/m2 of broadband (UVA/UVB) UV radiation …
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Structural studies of Burkholderia pseudomallei invasion protein D (BipD), 2,4'-dihydroxyacetophenone dioxygenase (DAD) and L-threonine dehydrogenase (TDH)
… However, because it is a novel structure, a selenomethionine derivative must also be crystallised and data collected; these optimisation trials are continuing. Structural knowledge about the enzymes involved in aromatic catabolic pathways will result in a better understanding of the whole …
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Nutritional control of gene expression, larval development and physiology in fish
… Here, dietary MOS, nucleotides and selenomethionine (Se-met) were offered to zebrafish whose transcriptome was analyzed by microarray. The immune system, humoral or cellular, innate or adaptive, exhibited different patterns of response according to the immunostimulating nutrient …
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Isotopic studies of selenium in environmental samples.
… techniques to release organically bound Se as selenomethionine and selenocysteine was found to be around 100% efficient and the use of a microwave oven increased the number of samples which could be processed. A sequential extraction procedure was used to determine the soil fractions with which …
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REPRODUCTION IN FATHEAD MINNOWS (PIMEPHALES PROMELAS) FOLLOWING WATER OR SEDIMENT EXPOSURE TO A COMPLEX URANIUM MILLING EFFLUENT ELEVATED IN SELENIUM
… compounds dropped to 53-68% and selenomethionine-like compounds increased to about 28%. The algae/biofilm present in the mesocosms was identified as key in the transfer of available Se into the food chain from the water and was a source of direct dietary exposure to fish and …
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Speciation Analysis of Arsenic and Selenium by HPLC and Mass Spectrometry
… in yeast the dominant species was found to be selenomethionine.
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Coal Combustion Residuals in Receiving Lake Ecosystems: Trophic Transfer, Toxicity, and Tracers
… additional lab-based dietary study of organic selenomethionine exposure sought to describe the bioenergetic consequences of low-level Se exposure to adult zebrafish (Danio rerio) and their offspring. Sex-specific metabolic effects were observed in whole organisms and individual tissue types and …