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Showing 1 to 20 of 27 for “"Selective reduction"”.
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Selective Reduction of Laterite Ore
The project studied reduction of garnieritic laterite ore with the aim to establish extent and rate of reduction of nickel, cobalt and iron oxides under different conditions, reduction mechanisms, and optimum conditions for selective reduction of nickel and cobalt oxides. Ore reduction with the …
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Asymmetric synthesis of (+)-altholactone, a styryllactone from various goniothalamus species
A consice and stereoselective route to highly functionalised a,b-unsaturated-d-lactone, (+)-altholactone (1), from the well-established 1,3-diol building block, dioxanone (2,2-dimethyl-1,3-dioxan-5-one) 4, is described. This approach is based on establishment of the chiral centres by applying a …
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Análise estática de estruturas com não-linearidade física localizada
… by making use of substructure concepts and selective reduction. In the former, the elastic components may be represented by small matrix of stiffness coefficients coupling then to the nonlinear elements. In the last a substantial part of the previously reduced coefficient matrix is re-used. …
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[4+1] cyclopentene annulation in the total synthesis of pentalenene type sesquiterpenes
… functional transformations emerged, such as the selective reduction of conjugated esters and a new method of preparation of enolethers from carboxylic acids.
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Synthesis of 2H-1-Benzthiocin: a Precursor for the Generation of the "4n+2" Pi-electron 1-Benzthiocinide Anion.
… <strong>14</strong> was prepared by LAH reduction of 2-mercaptobenzoic acid (thiosalicylic acid) in 95% yield. Oxidation of it with PCC afforded 2,2'-dithiobenzaldehyde <strong>15</strong> in 52% yield. A selective reduction of disulfide <strong>15</strong> to 2-mercaptobvenzaldehyde …
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Super electron donors powerful reductions performed by neutral organic molecules
… called Super-S.E.T. reagent 1, that allows the reduction of unactivated aryl and alkyl iodides. My study investigates the scope of donor 1 as a reducing agent and extends the study to a more powerful donor 2. Chapter One provides an introduction to the world of electron transfer. After giving a …
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Targeting the protein tyrosine phosphatase, SHP2, and PI3K in FLT3-ITD+ leukemia
… explanation for reduced proliferation and selective reduction of P-Erk levels in the N51-FLT3-Y768-expressing cells is through decreased recruitment of Grb2, which participates with son of sevenless, SOS, to activate the RAS-Erk signaling pathway. The lack of improvement in overall survival …
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Old protein, new perspective : the role of Oct-1 during embryonic development and lymphopoiesis
… defects of variable penetrance due to a selective reduction of β-globin expression. Cells derived from these embryos show a 40-fold decrease in protein activity and 30-fold decrease in total detectable Oct-i polypeptides as well as a complete lack of octamer-dependent promoter activity in …
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Binding of Pixantrone with DNA Bulge Sequences
… between isolated 5’-CpG and bulge sites. The selective reduction in the sequential NOE between the G7-A8 and A8-G9 nucleotides suggested that pixantrone binds at the bulge site by intercalation. Additionally, only NOEs from the pixantrone H7/H8 to A8H1’ were observed, indicating pixantrone …
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Macrocyclic chemistry: Part I - Characterization of a mixed-valence di-iron complex and synthesis of a new poly-iron complex. Part II - Synthesis, characterization of new diphosphoester macrocyclic polyethers
… or higher oligomers. Visible spectra of the selective reduction of iron mono-keto-macrocycles with boron trifluoride and triethylsilane showed a coupling reaction to form a di-iron complex. A mixture of iron mono-keto-macrocycic with iron diketo-dimacrocycle showed a new species with an …
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Recapitulation of Human Placental Insufficiency in a Novel Mouse Model :New Paradigm in Translational Research
… of the human PI. We tested the effects of selective reduction of placental blood flow by mesenteric uterine artery branch ligation (MUAL) reliably resulting in fetal growth restriction (FGR).Methods: At 18 days, timed mated C57BL/6J dams were divided into two groups: MUAL(n=18) ; and …
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The effect of hyperosmolarity on fluid-phase and receptor-mediated endocytosis in P388D1 macrophages
… fluid-phase uptake. Hypertonic conditions can selectively inhibit receptor-mediated endocytosis, leaving fluid-phase uptake unaffected, again suggesting that an alternative to coated pit-mediated uptake exists. In this study we determined the volume-weighted average diameter of primary …
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Targeted Inactivation of APE1 Endonuclease by E96A Mutation Sensitizes Pancreatic Ductal Adenocarcinoma to DNA-Damagin Therapy
… This dissertation tests the hypothesis that selective disruption of APE1 endonuclease activity destabilizes PDAC tumor homeostasis and sensitizes tumors to genotoxic therapy. To test this hypothesis, PDAC cell models with selective reduction of APE1 endonuclease activity were generated by …
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Contributions to benzothiopyran chemistry
… carboxylic acids in methanesuiphonic acid and selectively oxidised to their 1-oxides and 1,1-dioxides. Reduction and dehydration of the resulting benzothiopyran-4-ols gave the 2H-[1]benzothiopyrans and their 1-oxides and 1,1-dioxides, although the 1- oxides were more conveniently obtained by …
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Dearomative functionalization of simple arenes: Reduction and palladium-catalyzed syn-1,4-aminofunctionalizations
… for non-activated arenes which would allow site-selective introduction of functionality with concomitant loss of aromaticity would provide ideal platforms for accessing alicyclic structures with functional and stereochemical diversity. To this end, this thesis is based on the development of a …
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Non-Heme Iron Complexes Applied to Oxyanion Reduction
… tetrapodal ligands to study the multi-electron reduction of nitrogen and chlorine containing oxyanions. Previous work in our own lab showcased reduction of nitrate and nitrite (NOx- where X = 2 or 3) using a tripodal iron complex, forming the corresponding iron-nitrosyl or nitric oxide as the …
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Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism
… inhibitors for Pin1 were synthesized through a selective reduction using borane. The most potent inhibitor was found to be Fmocâ pSerâ Ψ[CH2N]-Proâ tryptamine, which had an IC50 value of 6.3 µM. This represents a 4.5-fold better inhibition for Pin1 than a comparable cis-amide alkene isostere. …
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Il trattamento neonatale con estradiolo modifica l'espressione e la funzione dei recettori GABAA e la sensibilità allo stress nel ratto adulto
… secretion, associated with persistent reductions in the cerebrocortical, hypothalamic and plasma concentrations of its metabolite, allopregnanolone. Given that allopregnanolone is a potent positive modulator of GABAA receptor (GABAAR) expression and function, it has been evaluated …
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Organokatalytische Synthesen biologisch aktiver Naturstoffe : Totalsynthesen von Amaminol A und B und (+)-Mitsugashiwalacton sowie Synthesen 2,6-disubstituierter Tetrahydropyranen
… of additional double bonds, but rather the reduction of an 1,2-unsaturated ester with magnesium successfully yielded the substrate for an organocatalyzed Henry reaction. The reaction also generated a new and interesting tricycle as a by-product, which occurs as a complex fragment in …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… to the ELS paradigm, revealed a significant reduction in the amplitude and frequency of miniature inhibitory post-synaptic currents (mIPSCs) c.f. WT controls. Non-stressed α2-/- mice exhibited similar alterations of mIPSCs properties c.f. WT controls. Complementary immunohistochemical …
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