Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Selective neuronal vulnerability"”.
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Selective Neuronal Vulnerability in Neocortices from Patients with C9ORF72-related Neurodegeneration
… and that pathology likely extends to other neuronal populations (Chapter 1). This may be especially evident in patients with the hexanucleotide repeat expansion in the gene C9ORF72 (c9HRE): the most common genetic cause of both ALS and FTD. We hypothesise that in c9HRE-related …
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Investigating Cell-Type-Specific Vulnerability in Mitochondrial Disease Using Stem Cell-Derived Neuronal Models
… yet the molecular and metabolic drivers of selective vulnerability in different neuronal subtypes remain poorly understood. In this thesis, I developed human stem cell-derived neuronal models for two nuclear-encoded mitochondrial disorders that impair mitochondrial DNA (mtDNA) replication …