Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Seizure threshold"”.
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IDENTIFYING THE GENETIC MECHANISMS IN SEIZURE THRESHOLD REGULATION
… defined by having recurrent and spontaneous seizures. The susceptibility to seizure is determined by seizure threshold, which describes the balance between excitatory and inhibitory neurotransmission in the brain. Epileptogenesis, the transition from normal brain to epileptic brain, is …
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Evaluation of Seizure Threshold as an Early Behavioral Marker of Disease Progression in the Mouse Model of Mucopolysaccharidosis IIIA
… including learning and memory deficits and seizure. MPS IIIA patients have short life expectancies and there currently is no cure for the disease. This thesis work was aimed at identifying an early neurological phenotype in the mouse model of MPS IIIA. The data will aid in the design of an …
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Neuromodulation by endogenous Interlukin-1β in hippocampus of the murine brain: Regulation of neuronal excitation
… further suggests that IL-1β regulates the innate seizure threshold, which arguably is a reflection of the homeostatic balance between excitation and inhibition (E/I) in the brain. Recognizing that the IL-1β signaling receptor, Interleukin 1 Receptor 1 (IL-1R1), is highly concentrated on granule …
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Investigating neural responses in models of neurocysticercosis
… responses to result in the development of seizures. In this thesis I have used the cestode Taenia crassiceps to develop multiple in vitro and in vivo models of neurocysticercosis in rodents. Utilising patch-clamp electrophysiology in organotypic hippocampal brain slices and chronic, …
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Computational Model of Electroconvulsive Therapy Considering Electric Field Dependent Skin Conductivity
… across subjects, their relationships to seizure threshold, and the role of head anatomy. Adaptive tES models demonstrated that current flow changes local tissue conductivity which in turn shapes current delivery to the brain in a manner not accounted for in fixed tissue conductivity …
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Electromagnetic Field Modeling of Transcranial Electric and Magnetic Stimulation: Targeting, Individualization, and Safety of Convulsive and Subconvulsive Applications
… electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) configurations that differ markedly in efficacy, side effects, and seizure induction efficiency could advance our understanding of the principles linking treatment parameters and therapeutic outcome and could provide a means of …