Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Segmentation clock"”.
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Analysis of the Zebrafish Segmentation Clock
… and their regulation in the PSM is termed the segmentation clock. Retinoic acid (RA) has been previously proposed to be a differentiation signal that acts to arrest the oscillations at the anterior of the PSM. This thesis shows the zebrafish RA catabolism mutant <i>giraffe</i> has an altered …
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The Regulation of Segmentation Clock Period in Zebrafish
… cycles of virtually all organisms, and the clocks that make entire populations of fireflies flash on and off in unison feature as prominent examples of biological clocks. During development, biological clocks regulate the patterning of growing tissues, as is the case in vertebrate …
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Investigating the relationship between clock gene stability and the pace of the vertebrate segmentation clock
… and their formation relies on ordered and timely segmentation during early embryonic development. Somites form as they ‘pinch’ away from the pre-somitic mesoderm (PSM) with a species-specific periodicity, coinciding with waves of cycling mRNA expression of ‘clock’ genes sweeping across the PSM …
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Novel Notch signalling dynamics within the molecular oscillator underlying vertebrate segmentation
… underlain by negative feedback loops termed the ‘segmentation clock,’ which manifests as a dynamic pattern of gene expression that sweeps the PSM in a caudo-rostral direction. Key components of the segmentation clock machinery are intracellular constituents of the Notch, Wnt and FGF signalling …
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Clock-based segmentation in the red flour beetle Tribolium castaneum
… germband elongation. In this work, I show that segmentation at both blastoderm and germband stages of Tribolium is based on a segmentation clock. Specifically, I show that the Tribolium primary pair-rule gene, Tc-even-skipped (Tc-eve), is expressed in waves propagating from the posterior pole …
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Molecular and biochemical characterisation of phosphorylation-dependent NICD1 turnover: novel roles for CDK1 and CDK2
In the developing vertebrate embryo, segmentation initiates very early and in a species-specific manner through the formation of somites, which later give rise to the vertebral column, most skeletal musculature and dermis. Somites are gradually and periodically pinched off from the anterior end of …
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A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
… analyses with marker genes implicated in the segmentation clock (e.g. her7), establishment of anterior-posterior (A-P) polarity (e.g. mesp) and differentiation of somites (e.g. myf5, lfng) revealed that the medaka mutants can be separated into two classes. Class I shows defects in tailbud …