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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 6 of 6 for “"Seed sequence"”.

  1. Microrna-mediated regulation and the fragile X family of proteins

    Cheever, Anne E.University of Illinois at Urbana-Champaign2010

    … an in vitro capture assay using a P-FMRP peptide sequence bound to agarose beads. These data show that Dicer containing complexes bind FMRP at amino acids 496-503 and that phosphorylation disrupts this association with a consequent increase in association with pre-miRNAs. In sum, we propose that …

    uiuc Repository record

  2. Stochastic modeling of biological sequence evolution

    Xu, KeyuanMassachusetts Institute of Technology2005

    Markov models of sequence evolution are a fundamental building block for making inferences in biological research. This thesis reviews several major techniques developed to estimate parameters of Markov models of sequence evolution and presents a new approach for evaluating and comparing estimation …

    mit Repository record

  3. Genome-Wide Decoding of mRNP and miRNA Maps

    Chi, Sung Wook

    … activity requires base pairing through only 6-8 "seed" nucleotides. By generating crosslinking of native Argonaute (Ago) protein-RNA complexes in mouse brain, Ago HITS-CLIP produced two simultaneous datasets—Ago-miRNA and Ago-mRNA binding sites—that were combined with bioinformatic analysis to …

    rockefeller Repository record

  4. Exploration of Nuclear Receptor Activity and siRNA-Derived Phenotypes as Therapeutics in Non-Small Cell Lung Cancer

    Carstens, Ryan Murray2017

    … phenotypes were largely mediated by miRNA-like seed sequence based effects rather than target-directed siRNA total complementarity silencing. Following this discovery, efforts were undertaken and subsequently completed to identify the "true" targets of these clade-specific siRNAs.

    utswmed Repository record

  5. The mechanism and function of pervasive noncoding transcription in the mammalian genome

    Wu, Xuebing, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2014

    … signals, the Ul signal, or 5' splice site sequences recognized by Ul snRNP during splicing, and polyadenylation signal (PAS), differentially mark the two sides of gene transcription start site (TSS), ensuring the generation of full-length mRNA but inducing early termination of uaRNAs. The …

    mit Repository record

  6. Das CRISPR-Cas-System von Haloferax volcanii - Voraussetzungen für eine funktionelle Interferenzreaktion

    Maier, Lisa-KatharinaUniversität Ulm

    ulm-diss Repository record