Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Sedative"”.
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Predicting the Effects of Sedative Infusion on Acute Traumatic Brain Injury Patients
… work involves investigating whether particular sedative agents (fentanyl, propofol, versed, ativan, and precedex) are associated with different discharge dispositions for patients with acute traumatic brain injury (TBI). To address this, we compare the effectiveness of various models …
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Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression
… and withdrawal is unclear. Zolpidem demonstrates sedative efficacy similar to BZs and has become a main treatment of insomnia in lieu of BZs. Zolpidem replaced BZs due to lower incidences of tolerance and withdrawal after prolonged treatment and discontinuation. Despite reported lower incidences, …
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The interaction of psychomotor stimulants and sedative hypnotics in the conditioned taste aversion paradigm
Specific pairs of drugs such as cocaine and ethanol and nicotine and ethanol are widely used by humans. A variety of existing studies have reported behavioral and pharmacological interactive effects between these pairs of drugs. The present thesis was designed to further examine the potential …
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Use and misuse of sedative drugs and related substances - Findings in the general population and in individuals with opioid dependence
Background: Prescription sedatives are efficient in the treatment of anxiety and sleeping disorders, but are associated with a risk of misuse and dependence, as well as an increased risk of accidents, injuries and overdoses, both in the general population and especially in individuals with other …
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Is non-medical use of prescription sedatives and sleeping pills associated with symptoms of depression, anxiety, and stress in undergraduate university students
… the association between the non-medical use of sedative and sleeping pills in the past three months and moderate-extremely severe symptoms of depression, anxiety, and stress in the past week, in undergraduate students at the University of Ontario Institutes of Technology (University of Ontario …
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Indagine etnofarmacologica su Casimiroa edulis Llave et Lex
… activity, anxyolitic, antidepressant, hypnotic-sedative, anticataleptic, anticonvulsant, antinociceptive and antinflammatory activities. The results revealed that the extract of seeds reduced spontaneous motor activity and rearing; in the forced swimming test (FST) it caused a potent sedative …
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Effects of varied types of music on singing voice and articulation in patients with Parkinson's disease
… the effects of singing "stimulative" and "sedative" songs to ascertain if different types of music affect articulatory precision in persons with Parkinson's disease. Articulatory precision was divided into six categories: rate, rhythm, initial consonants, final consonants, continuity, and …
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Functional Near-Infrared Spectroscopy (fNIRS) Based Functional Connectivity Alterations Associated with Delirium in Critically Ill Children: An Exploratory Study
… after false discovery rate (FDR) correction. Sedative opioid use also emerged as a significant predictor of delirium status. In a separate model examining delirium severity, higher CAPD scores were associated with greater sedative opioid exposure, younger age, and developmental delay. However, …
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Effect of Zolpidem, Zaleplon, and Ramelton on cognitive functioning after awakening from napping
Non-benzodiazepine sedative hypnotics and melatonin receptor agonist hypnotics induce the onset of sleep and are primarily prescribed for the treatment of insomnia. Although, non-benzodiazepine sedative hypnotic drugs zaleplon (Sonata) and zolpidem (Ambien) are not chemically like benzodiazepines, …
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The effects of antihistamine use on visual search tasks
… research has shown that most antihistamines have sedative effects and can lead to deterioration of psychomotor performance. The objective of this research was to determine if two antihistamines (diphenhydramine and astemizole) administered at a therapeutic dose level will affect a subject's visual …
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The Possible Role of Extra-Gonadal Metabolism of Steroids in The Regulation of Plasma Steroid Levels (Cytochrome P-450, Liver)
… compounds. Phenobarbital, a commonly used sedative, is known to increase the rate of hepatic metabolism and elimination of estrogen, progesterone and testosterone. The level of dietary protein is known to have a similar, albeit less predictable, effect on hepatic steroid metabolism.
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Spotting pain in the brain. Towards a useful animal model of pain
… outcome of drugs would clarify confounding sedative properties of drugs when assessing analgetic effects. Surface electrodes or ultrathin implantable electrodes were used to record the transmission to SI. We show that both a sedative and an analgesic compound can inhibit nociceptive …
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CUMULATIVE ANTICHOLINERGIC BURDEN AND ASSOCIATED OUTCOMES AMONG OLDER ADULTS WITH ALZHEIMER’S DISEASE
… and level of cumulative anticholinergic burden, sedative load, and opioid load and were measured as monthly burden/load calculated based on standardized dosing during a 12-month baseline and follow-up period among patients who had a delirium event compared with patients who did not have a …
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Ethical Considerations in Goals of Care for Patients with Polysubstance Use and Medical Complications in the Era of Xylazine
… introduces unique health risks due to its sedative properties, compounded when combined with fentanyl, leading to heightened potency and toxicity. This combination contributes to severe medical complications, notably injection-related infections driving hospitalizations. Ethical care for …
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Risk Factors for Postoperative Cognitive Dysfunction in Older Adults Undergoing Major Noncardiac Surgery
… using one or more highly anticholinergic or sedative-hypnotic drugs at home prior to surgery (OR = 5.64, 95% CI = 1.35 – 30.22), and receiving sevoflurane for anesthesia (OR = 6.43, 95% CI = 1.49 – 34.66) were risk factors for POCD. Conclusion: The incidence of POCD in older adults is 15.9% …
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Neonatal exposure to estradiol in female rats influences neuroactive steroid concentrations and behaviour in the adult rat
… anxiolytic, antidepressive, anticonvulsant, sedative-hypnotic effects and facilitates social behaviour, we assessed whether this treatment might modify different emotional, cognitive and social behaviours. This treatment did not affect locomotor activity, anxiety- and mood-related behaviours, …
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Paediatric procedural sedation current practice and challenges in Cape Town
… This is achieved partly by the administration of sedative, dissociative, or analgesic drugs which alter awareness, completely sedate the patient, reduce or eliminate pain.2,3,4 PSA is an essential component of Emergency Medicine practice and is a core skill acquired in Emergency Medicine training …
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Molecular orbital calculations of the activities of a series of CNS drugs
… testing procedures which examine the compounds' sedative and anticonvulsant activities. Each type of biological data was used to seek correlations with the molecular orbital. indices. Useful equations were calculated for six of the biological tests; these may prove to be useful for the prediction …
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The Effects of Allopregnanolone on Feeding: A Behavioural Investigation
… on spout approach behaviors and produced a mild sedative effect on vertical activity and licking without affecting horizontal activity. The present research supports the hypothesis that allopregnanolone-induced hyperphagia is the result of anxiety reduction without affecting other appetitive or …
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The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats.
… Older rodents were more sensitive to the sedative/hypnotic effects of acute ethanol compared to younger rodents. With the inclusion of three different developmental age groups, the current study provides a comprehensive view of age-dependent alcohol-induced motor impairments during the …
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