Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Secretory proteins"”.
-
Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
… mechanisms lead to death of host cells. Several proteins secreted from N. fowleri are likely to be associated with contactindependent pathogenic mechanism of the amoeba. The excretory and secretory proteins of N. fowleri (Nf-ESPs) include phospholipase, proteases, peroxiredoxins and thrombin …
-
Genetic analysis of Schizosaccharomyces pombe 7SL RNA
… of 7SL RNA, is required for translocation of secretory proteins into mammalian microsomal vesicles in vitro. In order to investigate the function of the RNA component of SRP, mutations were introduced into the S. pombe 7SL RNA gene by both site-directed and random mutagenesis.
-
Studies on the Secretory Process of Rabbit Parotid
… of aspects related to the last phases of the secretory cycle (concentration, storage, discharge). The work reported in this thesis characterizes the system and presents data concerning the relative rates of synthesis of membrane and content proteins. The dissected lobules can be maintained in …
-
In vitro studies on the SecA involvement in the assembly of an integral membrane protein with large hydrophilic domain
The transport of secretory proteins across the inner membrane of E. coli as well as the integration of inner membrane proteins takes place via the SecYEG-translocon. The targeting pathways of secretory and membrane proteins to the SecYEG translocon however, are different. Integral membrane proteins …
-
Characterization of SEC14: A gene essential for secretion in Saccharomyces cerevisiae
… whose product is required for export of yeast secretory proteins from the Golgi complex, was cloned and characterized. SEC14 was shown to be an essential gene for vegetative growth. Nucleotide sequencing revealed SEC14 to be an intron-containing gene, which encodes a 35 kD protein. Sec14p was …
-
Carbonic anhydrase from Methanosarcina thermophila: proposal of a new class of carbonic anhydrases and putative roles for the enzyme in anaerobic acetate catabolism
… properties characteristic of signal peptides in secretory proteins. The deduced amino acid sequence has no significant identity to any known CAs, but has, among others, 35% sequence identity to the first 197 deduced N-terminal amino acids of a proposed CO₂-concentrating-mechanism protein from …
-
The role of ERO1 in oxidative protein folding in the endoplasmic reticulum
… for the folding and stability of many secreted proteins. We describe an essential S. cerevisiae gene, ER01, which encodes a conserved ER membrane protein required for disulfide bond formation in the er .doplasmic reticulum (ER). In a conditional ero 1-1 mutant, secretory proteins that would …
-
Bioinformatic studies of small disulphide-rich proteins (SDPs)
Small disulfide-rich proteins (SDPs) include many secretory proteins which serve predatory, defensive or regulatory roles (such as toxins, inhibitors and hormones), and they are rich source for therapeutic drugs. Disulphide bridges play crucial roles in the 3D structure, function and evolution of …
-
The Effects of 5-Fluorouracil on The Secretory Process of The Rat Parotid Gland (Protein)
… no qualitative alterations in the types of proteins secreted. 5-fluorouracil treatment reduced the total glandular amylase per unit DNA in both unstimulated and isoproterenol-stimulated parotid glands. Decreased protein synthesis may be the mechanism underlying depleted secretory protein …
-
Serpin polymers enforce molecular filtration in the endoplasmic reticulum
Newly synthesised secretory proteins fold in the endoplasmic reticulum, failure of which can be toxic and cause disease. Alpha1-antitrypsin is the serine protease inhibitor (serpin) that is secreted mainly by hepatocytes and acts in lungs where its major function is to inhibit neutrophil elastase. …
-
Early Events in the Biosynthesis and Subcellular Consignment of Secretory and Membrane Proteins
… responsible for the segregation of secreted proteins and for the insertion of integral membrane proteins have been examined in light of the signal hypothesis. Model systems for the study of the biosynthesis of these different classes of proteins, as well as for the study of specific events …
-
Parallel effects of signal peptide hydrophobic core modifications on cotranslational translocation and posttranslational cleavage by purified signal peptidase
Secretory proteins are targeted to the secretory pathway by an amino terminal extension sequence known as the signal peptide. Signal peptides contain a central core of uncharged amino acids that are usually hydrophobic in nature. The hydrophobic core of the parathyroid hormone (PTH) signal peptide …
-
Investigating the Enteroendocrine - Brain Axis: Ghrelin Cell and ECL Cell Physiology and Ghrelin Action on Mood and Complex Eating
… the ghrelin cell's transcriptional profile, its secretory products other than ghrelin, and its relationship to other gastric endocrine cells, such as the histamine producing enterochromaffin-like cell. My doctoral research encompasses multiple aspects of the ghrelin system, from physiological …
-
Proteomic analysis of the olfactory mucosa, thoracic aorta, urinary bladder, and descending colon of smooth muscle alpha actin null mutant mice
… was to systematically characterize changes in proteins that are of structural and/or contractile significance and in proteins that may be indirectly affected by lack of functional SMAA. We hypothesized that the expression of various cytoskeletal and contractile proteins will be altered in …
-
Tyrosine Sulfation in A431 Cells
… a door towards enzyme purification Sulfation of proteins on tyrosine residues has recently been shown as a widespread occurrence. Most of the known tyrosine sulfated proteins are secretory proteins. The tyrosine sulfotransferase activity was suggested to be localized to the Golgi apparatus. In an …
-
Mutational Analysis of the Export Targeting Motif of Fibroblast Growth Factor 2, a Mediator of Tumor-Induced Angiogenesis
The majority of secretory proteins is exported from mammalian cells by the classical secretory pathway involving subcellular compartments such as the endoplasmic reticulum (ER) and the Golgi apparatus. However, basic fibroblast growth factor (FGF2), a potent mediator of tumor-induced angiogenesis, …
-
The Importance of RNA Sequence and Structure in the Assembly and Function of Signal Recognition Particle
… for the recognition and targeting of nascent secretory proteins to the endoplasmic reticulum, is composed of 7SL RNA, along with six polypeptides. Earlier work in our lab identified a homolog of 7SL RNA in S. pombe, showed by gene disruption that it is essential for viability, and demonstrated …
-
Molecular Mechanisms of SURF4- mediated Protein Secretion
… and processed in the Endoplasmic Reticulum (ER), secretory proteins are incorporated into transport carriers that are generated by the COPII coat. Efficient and accurate cargo incorporation into ER-derived carriers is driven by transmembrane cargo receptors. ER export receptors are especially …
-
Calcium: some aspects of subcellular accumulation and distribution in milk
… and Golgi apparatus; this was expected since secretory proteins and associated Ca are transported through these organelles for secretion. In vitro ⁴⁵Ca accumulation was compared in Golgi apparatus and endoplasmic reticulum from liver and mammary gland of lactating Dunkin Hartley guinea pigs. …
Page 1 of 2