Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"Secretome"”.
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Beneficial Fungal Secretome and Synthetic Consortia to Improve Soybean Growth During Drought Stress
Beneficial endophytic fungi may improve crop stress tolerance through soil carbon storage, water and nutrient acquisition, and stress mitigation. Our goal was to build a naturally occurring fungal synthetic community (FunSynCom) to improve growth and drought resilience in soybeans. In this study, …
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Uncovering Regulators of Whole-Body Metabolism by Chemoproteomic Profiling of the Adipocyte Secretome
… spectrometry to comprehensively characterize the secretome of murine visceral and subcutaneous white adipocytes and interscapular brown adipocytes. Over 600 proteins were identified, the majority of which showed cell type specificity with functional enrichment. BONCAT was also applied in vivo to …
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Detection of Sap2 in the secretome of Candida albicans cell wall and secretory mutants
Kandidát: Nikola Kollárová Názov diplomovej práce: Detekcia Sap2 proteínu v sekretóme kmeňov Candida albicans mutantných v bunkovej stene a sekrécii Univerzita Karlova, Farmaceutická fakulta v Hradci Králové, Katedra biologických a lékařských věd Complutense University of Madrid, Faculty of …
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Secretome Analysis in Higher Basidiomycetes - Freely Secreted and Cell Wall Proteins from Coprinopsis cinerea
Basidiomyceten sekretieren eine Vielzahl an Proteinen nicht nur in ihre weitere Umgebung, sondern auch in extrazelluläre Strukturen wie der Zellwand und der damit assoziierten äußeren Polysaccharid-Schicht. Ein detaillierter Überblick über das Sekretom von Coprinopsis cinerea fraktioniert in frei …
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Metabolomic insights into Pseudomonas aeruginosa behavior, secretome, and biofilm development using mass spectrometry imaging
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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A Fungal secretome tailored to enable a radical (oxidative) wood decay mechanism in brown rot fungi
… and soft rot fungi. This suggest that the fungal secretome in brown rot fungi has been tailored as a whole to better endure the presence of ROS. Also, we found that several of the oxidative modifications that occurred in the glycosyl hydrolases of T. reesei and T. versicolor happened in amino acid …
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A study of bioprocess designs for development of the myogenic secretome as a source of bioactive extracellular vesicles
The human skeletal muscle myoblasts (HSMM) secretome decreases cytokine-induced inflammation in chondrocytes, indicating potential as therapy for arthritis. The lack of an efficient scalable workflow for the human skeletal myoblast secretome limits its development as a source of therapeutic …
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Cancer Proliferation at the Brain Metastatic Site: A Proteomic Exploration of Inter-Cellular Cross-talk Sustained by Cell-membrane/Secretome Interactions
… analysis, this study focused on analyzing the secretome and cell surfaceome of metastatic breast cancer and brain-residential cells to reveal the interactions between these cells and contribution to various cancer-developing biological processes, including cell growth and proliferation, cell …
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Advancing detection, genomics, and secretome analysis of oomycete pathogens Phytophthora capsici and Phytopythium vexans to explore mechanisms of pathogenesis and biocontrol solutions
Soilborne oomycete pathogens pose persistent challenges to vegetable production systems, particularly in Ontario, Canada, where Phytophthora capsici and the recently reported Phytopythium vexans have emerged as significant threats. Understanding the molecular mechanisms underlying their …
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Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
… enterica subsp. enterica serovar Typhimurium secretome-induced pro-inflammatory mediator transcription and production by the Lacticaseibacillus rhamnosus R0011 secretome (LrS) in human IEC, indicating a potential for modulation of pro-inflammatory immune activity with minimal IEC impact in the …
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Modulation of protein expression in Mycobacterium tuberculosis-stimulated TB- IRIS patient-derived PBMCs by omega n-3 polyunsaturated fatty acids
… (MS)-based proteomic methods to probe the secretome of peripheral blood mononuclear cells (PBMCs) re-stimulated ex vivo with Mycobacterium tuberculosis (Mtb) whole cell lysate (WCL), and treated with n-3 PUFA. Optimization experiments were performed on cells obtained from eight healthy …
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Comparative proteomic analysis of Australian epidemic Bordetella pertussis
… immunisation background. Proteomic methods for secretome and surfaceome analysis was established. The B. pertussis secretome was characterised in Stainer-Scholte (SS) and Thalen-IJessel (THIJS) media. Ten virulence proteins were detected uniquely in THIJS while an additional 7 showed trends of …
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Role of The Immune System In The Modulation of The Mmr-Deficient Intestinal Stem Cell Niche
… by culturing organoids with macrophage secretome. Mass Spectrometry was also used to identify factors in the macrophage secretome that may have contributed to the observed changes. Overall, results indicate that there is a significant increase in the quantification of stem cell …
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The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
… a novel component of the differentiating stroma secretome and harness stroma biology to inform the use of a combination therapy for neuroblastoma treatment.</p><p>HBEGF expression is decreased in neuroblastoma compared to benign disease, correlating to an increase in mortality. HBEGF protein is …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… cell crosstalk on the T cell phenotype, the CAF secretome, and the adenosine pathway. In the first results chapter, peripheral blood – and tissue samples of non-cancerous lung (NCL) and tumour tissue from early NSCLC patients were used to assess the expression of CD39, CD103 and CD73 within …
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Secretion and Environmental Biochemistry of Legionella pneumophila in Corrosive Water
… species. In the third chapter, I report the secretome of endemic Flint, Michigan L. pneumophila in corrosive water, simulating the environmental impact of the Flint Water Crisis on local L. pneumophila populations. Our results from this study have expanded the secretome of L. pneumophila, …
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Mechanical modulation of indirect repair mechanisms for improved hematopoietic recovery
… to modulate MSC paracrine signaling or the MSC secretome. Like VECs, MSCs are known to respond to microenvironment cues such as substratum stiffness. We developed tissue-culture compatible PDMS-based substrata with tunable viscoelastic properties to assay potential mechanosensitivity. We …
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Mcp-1 Release Modulation Through Interaction of Pulmonary Endothelial Cells and Mesenchymal Stromal Cells
… to neutralize any secreted MCP-1.</p> <p>The secretome release of IL-1β, IL-1ra, IL-6, MCP-1, and VEGF were analyzed</p> <p>using ELISA (BD Biosciences and R&D Systems). To further understand the</p> <p>immunomodulatory response, the collected media from the previous step was added</p> <p>to …
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The Immune Inhibitor A1 Protease of <em>Bacillus Anthracis</em>
… cascade with far-reaching affects on the secretome. Using an intra-tracheal mouse model of infection, I found that an <em>inhA</em>-null strain is attenuated in relation to the parent strain. The data indicate that reduced virulence of the <em>inhA</em> mutant strain may be the result of …
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