Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1922 for “"Secretion"”.
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Stimulus-secretion coupling in Xenopus melanotropes: electrical activity, calcium oscillations and secretion
Contains fulltext : 146926.pdf (Publisher’s version ) (Open Access)
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Characterizing potential secretion components that increase secretion of recombinant proteins in Pichia Pastoris
… making this useful yeast into a more efficient secretion system that readily secretes problem proteins. In the Lin-Cereghino lab, mutant strains were developed by the method of restriction enzyme mediated integration. These mutants have the ability to secrete β-galactosidase at higher levels in …
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Molecular mechanisms of exosome secretion
… trafficking of MVEs and, ultimately, exosome secretion. We found that the conversion of phosphatidylinositol-3-phosphate (PI(3)P) to phosphatidylinositol-4-phosphate (PI(4)P) catalyzed by Myotubularin 1 (MTM1) and phosphatidylinositol 4-kinase type IIα (PI4KIIα) on the surface of MVEs mediates …
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Cytokine secretion in glioblastoma patients
… and the angiogenesis of the tumours. Cytokine secretion was evaluated from isolated peripheral blood mononuclear cells (PBMCs) of 33 patients with malignant gliomas (grade IV) immediately before surgery, in parallel with a control group of 23 age-matched individuals, and in 5 primary glioma …
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Packaging and Secretion of Airway Mucins
… dependent on the amount of agonist. Baseline secretion is responsible for steady clearance of inhaled particles and pathogens. Stimulated secretion is thought to play a role in trapping helminths though mucus occlusion in small airways.</p> <p>Mucin exocytosis is mediated by a four helix …
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Polarised secretion of leukaemia inhibitory factor
… the extracellular matrix. The polarity of LIF secretion has yet to be described and could illuminate the mechanisms of LIF localisation. Here the polarised endogenous secretion of human LIF and IL-6 in Caco-2 cells was characterised under normal culture conditions and following induction with …
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The Role of Microtubules in Secretion
… between the assembly of microtubules in vivo and secretion in response to a known secretagogue, Pilocarpine. The in vitro model .demonstrated an interaction between microtubules and the membrane of zymogen granules. Attachment was produced by the micro-tubule side arms and possibly a membrane …
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Control mechanisms of mammalian pepsinogen secretion
… the control mechanisms of mammalian pepsinogen secretion. In order to accomplish this goal, a comprehensive study was undertaken which would establish an historical perspective of the subject, validate appropriate methodology and then seek to answer specific questions regarding the physiology …
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Regulation of duodenal mucosal bicarbonate secretion
… studied the regulation of duodenal bicarbonate secretion in the anaesthetized guinea-pig, using a model that permitted the study of active transport of bicarbonate. It was determined that dibutyryl 3' ,5'-cyclic adenosine monophosphate, vasoactive intestinal polypeptide, prostaglandin E2, …
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Circadian Secretion of Glucagon-like Peptide-1
… (GLP-1) enhances glucose-stimulated insulin secretion following nutrient ingestion and has recently been shown to follow a circadian rhythm of secretion that parallels the expression of the core clock gene, Bmal1. However, the mechanisms by which the GLP-1 secretory rhythm is established and …
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Small gtp-binding proteins in insulin secretion
… which is characterized by defective insulin secretion and resistance to insulin. Understanding the molecular events leading to Glucose-stimulated insulin secretion [GSIS] might serve as therapeutic potential towards diabetes. GSIS involves interplay between small G-proteins and their …
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Endosomal Trafficking and Exosomal Secretion of Egfrviii
… by which it is packaged into exosomes for secretion. Moreover, I show that EGFRvIII secretion on exosomes can facilitate changes in the tumor microenvironment to enable tumor growth.</p>
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Regulation of Wingless secretion, distribution and signaling
… and processing of active Wnt ligands, Wnt secretion and gradient formation on the cell surface and in the extracellular matrix, and perception and signal transduction within the signal-receiving cells. Dysregulation of Wnt signaling underlies many human diseases, in particular, cancers. …
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Studies in the Control of Gastric Secretion
The problem of gastrlo physiology has absorbed the attention of Investigators since the days of the cunning Abbe Spallanzani who performed a series of weird and ingenious experiments on himself and on lower animals, in order to determine the nature of gastric digestion. Although noting the acid …
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Characterisation of cytokine secretion in malignant gliomas
… Multiformae patients have an altered pattern of secretion of cytokines compared with low-grade and non-cancerous patients. Lymphocyte subset analysis was performed using flow cytometry. Serum specimens taken from both high and low grade glioma patients were analysed with samples taken from …
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Factors influencing vitamin a secretion in macrophages
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Molecular Mechanisms of SURF4- mediated Protein Secretion
Protein secretion is an essential process that drives organelle biogenesis, cell growth and communication. Once synthesised and processed in the Endoplasmic Reticulum (ER), secretory proteins are incorporated into transport carriers that are generated by the COPII coat. Efficient and accurate cargo …
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Analysis of TpeL secretion in Clostridium perfringens
… gas gangrene. These diseases are caused by the secretion of specific toxins, though current treatments do little to nullify these toxins and better therapeutics are urgently needed. The development of such treatments is hindered by our poor understanding of clostridial toxin secretion, which is …
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The structural characterization of the Saccharomyces cerevisiae alpha mating factor secretion signal for recombinant protein secretion in Pichia pastoris
… The most successful and commonly used secretion signal leader in Pichia pastoris has been the MAT α prepro secretion signal. However, limitations exist as some proteins cannot be secreted efficiently even with the MAT α prepro secretion signal. Some strategies to enhance secretion …
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