Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Secretin"”.
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Regulation of Secretin the Neurohypophysis
Secretin (SCT) exists in the hypothalamo-neurohypophysis axis of the rat. Secretin receptor null mice show altered glomerular and renal tubular morphology along with mild polydipsia and polyuria. We hypothesize SCT may play a role in the physiology of water regulation in the rat. Water deprivation …
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Isolation and Use of the Aeromonas hydrophila Secretin ExeD for Nanopore Analysis
… its channel. A larger pore, using the type II secretin of Aeromonas hydrophila, may be able to circumvent the size constraint of α-hemolysin and could allow research into larger molecules to be made. The goal of this project was to isolate and use the type II secretin ExeD in nanopore analysis. …
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Entwicklung von Secretin- und Glucagon-like peptide-2-Rezeptor-Antagonisten für die Tumordiagnostik
… Arbeit konnte gezeigt werden, dass der humane Secretinrezeptor (SCTR), ein Vertreter der GPCRs der Klasse B, in 93 % aller untersuchten duktalen pankreatischen Adenokarzinome und in 94 % aller untersuchten Plattenepithelkarzinome des Ösophagus stark exprimiert wird, während das umgebende Gewebe …
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The action of magnesium upon stimulus-secretion coupling in the exocrine pancreas
… of Na+ and is ATP-dependent. Stimulation with secretin results in an elevation of [Mg2+] compared to resting values. The secretin-evoked elevation of [Mg2+] may be coupled to G protein activation of adenylate cyclase. Digital imaging technology further demonstrates that mobilisation of Mg2+ …
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Identification of Previously Unknown Interactions Between G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
… to modulate the function of several GPCRs in the secretin-like GPCR family. GPCR-RAMP interactions were shown to affect the ligand binding affinity of two different secretin-like GPCRs, causing the functional diversity of the GPCRs to be driven by an interacting protein. Yet, potential direct …
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Stimulus-secretion coupling in the exocrine pancreas of the rat: Interactions between secretagogues
… & CCK8) and pancreatic juice secretion (CCK8 & Secretin) in the rat pancreas. 2. Modifications in extracellular Mg 2 affected ACh-evoked 45Ca2 influx, efflux and intracellular free C a2+ mobilisation. Elevated extracellular Mg2+ (10 mM) depressed whereas, zero extracellular Mg2+ (0 mM) augmented …
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Duodenal pH : new aspects of physiology and pathophysiology
… stimulation and a meal on plasma gastrin, secretin and somatostatin and duodenal pH were examined in healthy subjects and duodenal ulcer patients. The results showed: vagally-released gastrin is not a significant contributor to stimulation of gastric acid secretion in either health or …
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The test meal and exocrine pancreatic function
… that various drugs and later the two hormones, secretin and pancreozymin, were used to stimulate pancreatic secretion. These two hormones very soon completely replaced any other method of pancreatic simulation. The intravenous injection or infusion of secretin and/or pancreozymin is, however, …
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Endogenous glucagon-cells are necessary for the glucose-responsiveness of the HIT-T15 hamster β-cell line
… glucagon, glucagon-like polypeptide-I, GIP, secretin, pancreatic polypeptide (PP) and peptide-tyrosine-tyrosine (PYY). Staining was positive for all peptide hormones tested except somatostatin, secretin and GIP. Insulin, glucagon and PYY were the dominant peptides. Double staining of HIT-T15 …
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On the interdependence of pancreatic size, and tissue composition and cellularity, and growth : characterization of a caerulein-generated model of enhanced pancreatic growth in the adult male rat
… to the trophic effects of agents such as secretin, glucocorticoids and EGF on this organ. Description of pancreatic size, tissue composition and glandular DNA levels during the initial times (0hrs-24hrs) following implementation (PRI) of secretagogue-models (caerulein, 1µg/kg BW/injection, …
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Multiplexed Mapping of the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
… for several GPCRs, mostly belonging to the secretin family. However, the pervasiveness of GPCR-RAMP interactions and the mechanisms of their effects are not well understood. Recent bioinformatics and experimental studies suggest that GPCR-RAMP interactions might be much more widespread than …
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Mechanisms associated with secretory and contractile responses in tissues and cells of the body in health and disease
… hormones. Cholecystokinin-octapeptide (CCK), secretin and histamine can stimulate protein and enzyme secretion from the pancreas. In addition to innervation pattern, this study also investigated the cellular mechanisms of stimulus-secretion coupling. The results have shown that there are four …
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The Functional Characterization of the Quorum Sensing E. Coli Regulators B and C in EHEC
… hormones, including gastrin, galanin, and secretin. Additionally, autophosphorylation can be antagonized upon the addition of phentolamine, an a-adrenergic receptor antagonist. Given that enterocytes harbor a-adrenergic receptors, it would be consistent for a microbial adrenergic sensor …
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Interaction of Putative Estrogens and the Estrogen Receptor System in Leydig Cells in the BALB/c Mouse Testis Resulting in the Initiation of DNA Synthesis
… applicable to adrenaline, thyroid hormone, and secretin.</p> <p>The term "hormone" was introduced by Starling (1905) meaning to excite or arouse. Starling recognized that hormones traveled through the blood stream to their target organs, and that the body produced them according to physiological …
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Activation mechanisms of non-class A G protein-coupled receptors
… (GLP1R), Parathyroid Hormone 1 receptor (PTH1R), Secretin Receptor (SCTR) and Pituitary Adenylate Cyclase 1 receptor (PAC1R), and fungal Class D receptor STE2, using large-scale all atom unbiased molecular dynamics simulations. To overcome the limitations associated with traditional MD …
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Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
… regions of GLP1R, glucagon receptor (GCGR), secretin receptor (SCTR), and corticotropin-releasing factor receptor type 1 (CRF1) were therefore investigated. Whilst some effects were observed when GLP1R was mutated, in many cases these SNPs had little effect on signalling. However, mutation of …
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Wirkung von Sekretin auf Neurotransmitter im Hippokampus der Ratte
Auslöser zur Durchführung der vorliegenden Arbeit war eine amerikanische Studie, in welcher bei autistischen Kindern fünf Wochen nach einmaliger intravenöser Sekretinapplikation eine deutliche Symptomverbesserung beobachtet werden konnte (Horvath et al., 1998). Ziel der vorliegenden Arbeit war die …
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Role of Salmonella enterica subspecies enterica serovar Enteritidis pathogenicity island-2 in chickens
… proteins used for vaccine studies included the secretin, SsaC, the needle, SsaG, the filament, SseB, and a part of the translocon, SseD, as well as a number of effectors, SseI, SseL, SifA, and SifB. The first vaccine study involved vaccination of SPF chickens with SseB and SseD, followed by …