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Showing 1 to 6 of 6 for “"Secreted Protein Acidic and Rich in Cysteine"”.
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
<p>THE ROLE OF THE SPARC ACIDIC DOMAIN AND EGF-LIKE MODULE IN GLIOMA MIGRATION, INVASION, AND SIGNALING</p> <p>HEATHER M. MCCLUNG</p> <p>Advisor: Sandra A. Rempel, Ph.D.</p> <p>Major: Pharmacology</p> <p>Degree: Doctor of Philosophy</p> <p>We have previously shown that Secreted Protein Acidic and …
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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis
<p>Pulmonary fibrosis involves the invasion of lung tissue with fibrotic, scar tissue and affects roughly five million people total worldwide. Fibrotic development in the lung has several causes, including chronic inflammatory diseases, infections, medical compounds, and environmental agents. There …
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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis
<p>Pulmonary fibrosis involves the invasion of lung tissue with fibrotic, scar tissue and affects roughly five million people total worldwide. Fibrotic development in the lung has several causes, including chronic inflammatory diseases, infections, medical compounds, and environmental agents. There …
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Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor
<p>Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotypic changes related to malignant progression including a shift to estrogen independent growth, increased cell motility and invasion. Concurrent with these phenotypic changes are alterations to …
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Investigation of the proteins SPARC and HMGB1 in chronic airways disease
The matricellular protein, secreted protein acidic and rich in cysteine (SPARC), mediates the interaction between cells and their surrounding extracellular matrix (ECM) but does not contribute structurally to the matrix. It regulates basic cellular functions such as cell adhesion and proliferation, …
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Development of novel polymeric nanoparticles for pancreatic cancer therapy
… cancer sufferers are faced with a dire prognosis in part because no curative chemotherapy regimen exists. The first-line pancreatic cancer combination therapy of folinic acid, 5-fluorouracil, irinotecan and oxaliplatin (FOLFIRINOX) comes with significant toxicity and is only tolerable by some …