Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Secondary pharmacology"”.
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Predictive Modelling of the Primary and Secondary Pharmacology of Compounds in Drug Discovery
Understanding the primary and secondary pharmacology of drugs is imperative for delivering a drug molecule which has the necessary efficacy and safety profile in humans. The application of machine learning and data mining methods to drug discovery has the promise to accelerate the drug discovery …
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Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data
… that were previously reported in the context of secondary pharmacology screening, at the cost of a lower recall, possibly due to the smaller size of the dataset with available plasma concentrations. Furthermore, a large-scale quantitative assessment of bioactivities as indicators of AEs reveals a …
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Establishing species-specific 3D liver microtissues for repeat dose toxicology and advancing in vitro to in vivo translation through computational modelling
… variance in predictability of the primary and secondary pharmacology of foreign chemical substances, as well as variability in individual susceptibility within the population [1]. Despite a wealth of research into this field, our understanding of the mechanisms underpinning the occurrence of …