Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"Secondary metabolite"”.
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The Role of the Alternaria Secondary Metabolite Alternariol in Inflammation
… project was to assess the role of Alternaria secondary metabolites that are synthesized by genes called polyketide synthases (PKS) in immune responses of lung epithelial cells.
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Secondary Metabolite Production By An Endophytic Bacillus sp. from Platanus Occidentalis
… inhibitors of the hepatitis C virus (HCV). The secondary metabolite production of the endophytic B. amyloliquefaciens was investigated under a variety of fermentation conditions. It was discovered that the endophyte produces rapamycin, a molecule previously reported only from Streptomyces …
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Functional Analysis of Secondary Metabolite Biosynthesis-Related Genes in Alternaria brassicicola
… renowned for its ability to prodigiously produce secondary metabolites. To test the hypothesis that secondary metabolites produced by A. brassicicola contribute to pathogenicity, we identified seven nonribosomal peptide synthetases (NPSs) and 10 polyketide synthases (PKSs) in the A. brassicicola …
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Stress and release : chemical modulation of secondary metabolite production in Aspergillus sp.
Cyclosporin A induced biosynthesis of colored compounds in three species of Aspergillus. Diode array HPLC MS analysis of culture extracts revealed Aspergillus terreus demonstrated the most profound response, with upregulation of more then twelve compounds from three distinct chemical families; …
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New Pleiotropic Co-Regulators of Gas Vesicle and Secondary Metabolite Production in Serratia sp. ATCC39006
… environments. S39006 also produces various secondary metabolites, including the tripyrrole red-pigmented antibiotic, 2‐methyl‐3‐pentyl‐6‐methoxyprodigiosin (prodigiosin; a prodiginine) and the β-lactam antibiotic, 1-carbapen-2-em-3-carboxylic acid (a carbapenem). The production and …
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Substrate elucidation and mutasynthesis: Characterisation of the biosynthetic pathway of a tripyrrolic secondary metabolite, prodigiosin
… biological activity can be found in the realm of secondary metabolites. The tripyrrole prodigiosin illustrates this perfectly with activities ranging from antimicrobial to immunosuppressive and anticancer. Microorganisms producing the red pigment prodigiosin were first isolated more than 150 years …
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Novel pleiotropic regulators of flotation, secondary metabolite production, and virulence in Serratia sp. ATCC 39006
Serratia sp. ATCC 39006 (S39006) is a Gram-negative, rod-shaped enterobacterium known for the production two antibiotics; the β-lactam, 1-carbapen-2-em-3-carboxylic acid (a carbapenem) and the red-pigmented tripyrrole, 2-methyl-3-pentyl-6-methoxyprodigiosin (prodigiosin; a prodiginine). It also …
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The role of post-transcriptional regulators in pathogenesis and secondary metabolite production in Serratia sp. ATCC 39006.
… (Caenorhabditis elegans) models. It produces two secondary metabolite antibiotics, prodigiosin and a carbapenem, and the plant cell wall degrading exoenzymes, pectate lyase and cellulase. A complex regulatory network controls production of prodigiosin, including a quorum sensing (QS) system, and …
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An investigation on the effects of cyanopeptides on the growth and secondary metabolite production of Microcystis aeruginosa PCC7806.
… are also one of the best sources of natural secondary metabolites (cyanopeptides) some of which have harmful effects on the ecosystem, while others may be beneficial. It is known that these secondary metabolites are continuously produced during growth, however, it is not known whether the …
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A path to biodiscovery: isolating Antarctic ascidian-associated bacteria and screening genomes for secondary metabolite-encoded biosynthetic gene clusters and signatures of cold adaptation
… marine ascidian, the diversity and potential for secondary metabolite production within its microbial community, and trends observed in protein and genome sequences of cold adapted organisms.
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A quantitative study of the relationships between morphology, physiology and geldanamycin synthesis in submerged cultures of Streptomyces hygroscopicus var. geldanus
Microbially produced secondary metabolites such as antibiotics have tremendous economic importance. However, most are produced by filamentous organisms which exhibit diverse growth patterns presenting challenges for industrial fermentation. There are many factors affecting secondary metabolite …
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Pengaruh penambahan ZPT 2,4-D dan PEG (Polyethylene Glykol) 6000 pada media MS (Murashige & Skoog) untuk produksi metabolit sekunder pada kultur kalus stevia (Stevia rebaudiana Bertoni M.)
… that efective in increasing the production of secondary metabolite in callus stevia (Stevia rebaudiana Bert. M) wiht In Vitro. PEG 6000 which is one of to manipulated growing media wiht In Vitro for increasing the secondary metabolite. PEG is a compound that can lower the osmotic potential of …
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Secondary Metabolites from Xylaria Endophytes: The isolation and structure elucidation of secondary metabolites from Xylaria endophytes by chemical and spectroscopic methods
… the isolation and structure elucidation of secondary metabolites from a number of endophytic Xylaria fungi. Six Xylaria endophytes were surface cultured on an aqueous malt extract-glucose medium. The fungus A311R, from a palm tree in Thailand, produced nonane-1,2,3-tricarboxylic acid, which …
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Fusarium poae: Secondary Metabolism and Accessory Chromosomes
… chromosomes can encode transcriptionally active secondary metabolite biosynthetic gene clusters (BGCs), high numbers of transposable elements, and undergo frequent sequence duplications, disruptions, inversions and translocations compared to core chromosomes. The presence of accessory chromosomes …
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Antimicrobial activities and diversity of sponge derived microbes
… bacteria and fungi, was investigated for its secondary metabolite genes. At least 5 different NRPS genes, with a sequence similarity as low as 50 % to known genes, were identified highlighting the likelihood that this isolate may be capable of producing novel secondary metabolites. A …
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Marine natural products as antimicrobial chemical defenses and sources of potential drugs
… involved in biosyntheses of these molecules. Secondary metabolite pathways probably evolved to mediate interactions between organisms in their natural habitats; however, the ecological functions of natural products remain poorly understood for the vast majority of cases. In the present series …
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The roles of secondary metabolites in microcystis inter-strain interactions
… on the genomic as well as on morphological and secondary metabolite levels. Microcystis communities are composed of a variety of diversified strains. The focus of this study lies on potential interactions between Microcystis representatives and the roles of secondary metabolites in these …
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Untersuchungen auf Sekundärstoffproduktion und physiologische Charakterisierung von marinen heterotrophen Bakterien aus dem deutschen Wattenmeer
… Wadden Sea were screened for their potential for secondary metabolite production. 16 S rRNA gene analysis revealed, that 56 strains affiliated with Gram positive bacteria and 36 strains with the Roseobacter-clade (alpha-Proteobacteria). To avoid the problems of culture dependent screening …
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