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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Secondary amines"”.
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Alpha-lithioamine synthetic equivalents from N-Boc secondary amines: Piperideine, pyrrolidine, and perhydroazepine
… of carbamates from unactivated cyclic secondary amines; piperidine, pyrrolidine, and perhydroazepine to provide $\alpha$-lithioamine synthetic equivalents. The Boc group can be easily introduced on the nitrogen, stable to strong alkyllithium bases, and easily cleaved after elaborations. …
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Charge-Transfer Complexes for Amine Synthesis
… reaction was developed, combining secondary amines, cyclopropyl carboxaldehydes and alkenes, to generate cyclopentyl methylamines. To initiate the fragmentation step, single-electron reduction of alkyliminium ions to α-amino radicals was achieved, using an aromatic thiol and visible …
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Activated carbon catalyzed nitrosamine formation via amine nitrosation
Nitrosamines have garnered increasing attention from researchers and policy makers in recent years due to potential human health implications associated with their unintentional formation in water and wastewater treatment facilities. This work addresses a crucial nitrosamine formation pathway …
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Palladium(II)-Catalysed sp 3 C–H Functionalisation of Hindered Amines and its Application in Synthesis of Astemizole Analogues
… C–H carbonylation of hindered secondary amines is described. Central to this strategy is the temporary conversion of simple ketones into hindered secondary amines that facilitates a sterically promoted palladium-catalysed C–H activation. A range of functional groups are shown to …
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Serum Stable Carbohydrate-Oligoethyleneamine Copolymers for Nucleic Acid Delivery
… was copolymerized with linear oligoethyleneamines of varying length and containing alkyne end-groups via step-growth Cu(I)-catalyzed azide-alkyne cycloaddition polymerization resulting in a series of trehalose copolymers with a range of secondary amines (from 4 to 6) within the polymer …
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Part One: Photochemistry of Aryl Azides. Chemical Properties of the Transient Intermediates. Part Two: Thermolysis of an Endoperoxide. Generation of an O-Xylylene Peroxide (Nitrene)
… intermediates and their rates of reaction with secondary amines are discussed.
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Multi-component Reactions Initiated via Sonogashira Coupling
… can now undergo a Michael addition with suitable secondary amines. This coupling-aminovinylation sequence can be performed in a one-pot fashion, providing a straightforward access to push-pull chromophores. By applying acid chlorides instead of arylbromides, it was possible to synthesize ynones …
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Novel syntheses by directed lithiations of N-Boc benzylamines and cyclopropylamines
The lithiation-substitution of N-Boc benzylamines and cyclopropylamines have been investigated to explore the synthetic potential of these substrates. We have achieved the syntheses of highly enantioenriched benzylic $\alpha$-substituted N-Boc secondary amines using RLi/(-)-sparteine. Extension of …
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The Photochemistry of 3- and 4-Nitro Phenyl Azides
… of the triplet nitrenes can be trapped by secondary amines. The mechanisms of these reactions are discussed.
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Part I: Palladium PEPPSI-IPENT CI, A Useful Catalyst for Challenging Amination Reactions Part II: Generation Of Benzynes in Flow Reactors followed by Subsequent Diels-Alder Reactions
… a) coupling of sterically hindered primary and secondary amines and b) coupling of 2-aminopyridine derivatives with aryl and heteroaryl halides. Although several approaches have been developed and proven to be effective for coupling of sterically hindered amines, they have limited utility and …
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Synthesis of gemcitabine and it's tetrafluorinated analogues
… has been investigated with a range of amines. The methodology proves high-yielding for primary amines and lesshindered secondary amines. In contrast to expectations, their stability in acidic media was not very high. Anomerisation and ring isomerisation studies have been conducted
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Toxicity of aliphatic amines on the embryos of zebrafish Danio rerio - experimental studies and QSAR
The toxicity of 36 aliphatic amines on the embryos of the zebrafish Danio rerio were investigated. The DarT (Danio rerio Toxicity assay) was used to determine the lethal concentrations within a 48 h static acute toxicity test. A QSAR (Quantitative Structure-Activity Relationship) was performed …
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Palladium-Catalysed Functionalisation of Csp3–H Bonds Directed by Aliphatic Amines
… on medicinally-relevant aliphatic amines are valuable in the diversification of molecules designed as pharmaceutical agents. This thesis describes two Csp3–H functionalisation reactions, using native amines (secondary and tertiary) to direct C–H activation. Chapter 2 describes a …
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Development of new transition metal catalysts for C-N bond formation and continuous flow processes for C-F bond formation
… electrophiles and aryl, heteroaryl, and alkyl amines. The catalyst system is also compatible with weak base, allowing for the amination of substrates containing base-sensitive functional groups. Chapter 2. Design of New Ligands for the Palladium-Catalyzed Arylation of a- Branched Secondary …
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New axially chiral amine organocatalysts
… now ubiquitous binaphthyl backbone. The tertiary amines synthesized were shown to be effective nitrogen transfer reagents in the asymmetric aziridination of chalcone substrates, with enantiomeric excesses of up to 37% seen. The first example of an isolated chiral hydrazinium salt being used as a …
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Expanding the substrate scope in palladium-catalyzed C-N and C-C bond-forming reactions
… -neutral aryl nonaflates with both primary and secondary amines. Using XantPhos, the catalytic amination of a variety of functionalized aryl nonaflates resulted in excellent yields of anilines; even 2-carboxymethyl aryl nonaflate is effectively coupled with a primary alkyl amine. Moderate yields …
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Diels -Alder reactions of [60]fullerene with 1,2,4,5-tetrazines and additions to [60]fullerene-tetrazine monoadducts
… monoadducts also react with primary amines in a similar fashion. The proposed mechanism for the reaction between [60]fullerene-tetrazine monoadducts and primary amines is similar to that proposed for the hydration/rearrangement reaction.</p><p>The [60]fullerene-tetrazine monoadducts …
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Synthesis and Characterisation of Phosphenium Ions with Aromatic Amido Substituents
… 4 are synthesized in three steps by reacting the secondary amines 1 with nBuLi, which results in the production of the appropriate lithium amide salts (2) followed by subsequent reaction with PCl3, which yields the chlorophosphines 3. Reaction of 3 with a halogen abstracting reagent such as AlCl3 …
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New strategies for the synthesis and functionalization of aliphatic amines
… chemicals into pharmacologically-privileged amines is a landmark challenge in organic synthesis. This thesis describes the development of three novel transition-metal catalyzed processes for the synthesis of alkylamines that attempts to meet this challenge. The first Pd-catalyzed methylene …
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