Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Secondary Infections"”.
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Mathematical Modeling of Dengue Viral Infection
… to each of the four serotypes of dengue virus, secondary infections of dengue put patients at higher risk for more severe infection as opposed to primary infections. The current hypothesis for this phenomenon is antibody-dependent enhancement, where strain-specific antibodies from the primary …
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Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice
… protective Th2 immunity against both primary and secondary infections with N. brasiliensis. Our findings demonstrate that CD28 is required for initiation of protective Th2 immunity against primary infection with N. brasiliensis. Furthermore, the absence of CD28 impairs development of memory CD4⁺ T …
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Nosocomial infections in intensive care
… pathogenesis, diagnosis and management of secondary infections in the Intensive Care Unit. 2) To present the findings of a study of the technique of selective parenteral and enteral antisepsis regimen (SPEAR) in the patient population of the Respiratory ICU at Groote Schuur Hospital, aimed …
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Immunoepidemiological Modeling of Dengue Viral Infection
… hypotheses for the increased severity during secondary infections are antibody dependent enhancement and original antigenic sin. Antibody dependent enhancement suggests that long-lived antibodies from primary infection remain during secondary infection but do not neutralize the virus. Original …
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Influenza Virus Detection and Surface Decontamination using Ozone Gas
… year (Centre for Disease Control, 2022). These infections can be the precursor to secondary infections such as pneumonia, thus posing a risk to the population. This could be mitigated by implementing a method to accurately diagnose patients with Influenza, thus allowing them to get treatment …
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Childhood epidemics and the demographic landscape of the Aland Archipelago
… These results are consistent with deaths from secondary infections due to measles-induced immune suppression, but not conclusive. The unknown impact of measles exposure on adults with antibodies, and the variety of other diseases and symptom descriptions, indicates that the possibility of …
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Microbiota-host interactions and infection dynamics in critical illness.
… ill patients in the ICU experience high rates of secondary infections, largely attributed to immune dysfunction and impaired host defense. We recently reported that intestinal dysbiosis in critically ill patients is associated with expansion of hypofunctional immature neutrophils, resulting in a …
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Mathematical models of daphnia epidemics
… in reducing disease prevalence and the number of secondary infections. Through this thesis we have gained more insight into the biology of our system, and more importantly we open the door to new and exciting questions. As new biological insights are discovered, we can use mathematical models to …
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Centre Manifold Theory for some continuous and Discrete Epidemiological models
… R0. This is defined as the average number of secondary infections that occur when one infective is introduced into a susceptible host population. In this setting and for many diseases, the prediction of the likelihood of persistence or dying out of the disease within the population reads as …
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Molecular characterization of economically important poultry viruses in western Canada
… and causing economical losses due to secondary infections and plant condemnations. In recent years, these diseases have gained importance in western Canada as a result of the economic losses sustained from these infections in: a) feed conversion, b) high number of culls/first week …
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Evaluating the impact of point-of-care diagnostics on disease outbreaks in low resource settings
… testing could significantly reduce the number of secondary infections during an outbreak. This finding is shown to be true across outbreaks of varying sizes and transmission characteristics and for devices with varying accuracy performance.
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Epidemiology, Aphid Vectors, Impact and Management of Tobacco Etch Potyvirus in Hot Peppers in Jamaica
… Field spread of TEV to pepper was mainly by secondary spread from primary infections. Secondary infections were spatially correlated to primary infections for up to 25 meters. Natural infections of TEV were associated with aphid flight activity. Over 30 species of aphids were collected on …
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Stimulating antibiotic development by targeting virulence and facilitating natural product discovery
… the microbiome, which may decrease the risk of secondary infections and slow the spread of resistance. One such narrow-spectrum strategy is to target the virulence factors employed by pathogens during an infection. In chapter 2, I demonstrate that the FDA approved HIV protease inhibitor …
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Modeling transmission heterogeneity for infectious disease outbreaks
… number (Ro) - namely, the average number of secondary infections caused by an index case in a fully susceptible population. Typical approaches to modeling transmission dynamics associated with infectious disease outbreaks frequently use Ro to produce deterministic case count projections, in …
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Monitoring immune dynamics following infection and vaccination using B cell receptor sequencing
… suppression result in increased incidence of secondary infections up to 3 years after resolution of measles. Vaccination against measles virus with the MMR vaccine has been a major factor in reducing direct and secondary childhood morbidity and mortality. The maintenance of sufficient global …
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Role of Multiple Toll-Like Receptor Activation in Regulating Cytotoxic T Cell Priming to Lympocytic Choriomeningitis Virus Infections
… to shaping host immunity during concurrent viral infections. Since nitric oxide (NO), an innate effector immune molecule, was recently suggested to regulate proteasome activity; we sought to examine if NO can influence MHC-I antigen presentation during viral infections. The data in this section of …
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Cas9-Primed Adaptive Immunity During the CRISPR-Cas Response
… response, priming allows the host to anticipate secondary infections by escaper and related viruses. This "prophylactic" immunity is a unique feature in CRISPR systems that allows type II systems to overcome future threats from viruses that would have overcome the defense provided by the initial …
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Epidemiological studies on primary inoculum of Venturia inaequalis and V. asperata for apple scab management
… treatments, especially targeting ascosporic infections. To reduce the pesticide input, sanitation practices against overwintering inoculum, decision support systems for an optimal timing of treatments, and resistant cultivars can be used. However, reducing pesticide pressure increases the …
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Elucidating the mechanisms and dynamics of drug-mediated inhibition and latency reversal in HIV-1 (HIV-1)
… a disease that causes the host to succumb to secondary infections. There is currently no cure for HIV-1 infection, but Highly Active Anti-Retroviral Therapy (HAART) can bring the viral load in patients down to undetectable levels in the blood (<50 copies/mL). Furthermore, when the minimal …
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Intrinsic alterations of the skin barrier function promote the pathogenesis of atopic dermatitis in dogs
… with AD have a high susceptibility to cutaneous secondary infections. In the past decades, it has been suggested that the reason for the high incidence of cutaneous infection in atopic people is due to defects in the skin barrier function such as deficiency of keratinocyte-secreted natural …
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