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Showing 1 to 6 of 6 for “"Secondary Hyperparathyroidism"”.
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Characterizing the Development of Secondary Hyperparathyroidism and Vitamin D Resistance in Experimental Chronic Kidney Disease
… is a mainstay therapy for the treatment of secondary hyperparathyroidism (SHPT) that develops in CKD. A major issue with therapy includes the development of calcitriol resistance and increased vascular calcification. Modifications to the PTG that hinder its sensitivity to calcium (Ca) and …
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Nuclear-Medical Methods for Diagnosing of Abnormal Parathyroid Glands in Primary and Secondary Hyperparathyroidism // Нуклеарно-медицински методи за диагностика на абнормни паращитовидни жлези при първичен и вторичен хиперпаратиреоидизъм
Първичният хиперпаратироидизъм (ПХПТ) се дължи на свръхпродукция на паратироиден хормон (ПТХ) от една или повече абнормно променени паращитовидни жлези и води до развитие на хиперкалциемия. Доскоро считан за рядко заболяване, в последните години с навлизане в клиничната практика на рутинно …
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The effect of continuous infusion of human parathyroid hormone on bone architecture in female mice
This research sought to create an animal model of secondary hyperparathyroidism through continuous infusion of parathyroid hormone (PTH) in adult female mice, and to subsequently study the catabolic effects of PTH. Osmotic pumps were implanted subcutaneously and infused either vehicle, 40 pg/kg/day …
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Changes of parathyroid hormone and vitamin D metabolites according to glomerular filtration rate in chronic kidney disease patients
… abnormalities are addressed and treated. While secondary hyperparathyroidism develops during the early stages of chronic kidney disease, few patients are evaluated for elevations in serum parathyroid hormone (PTH) before they become frankly hypocalcemic. Quantification of the prevalence of these …
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PARATHYROID HORMONE ACTIVITY AND RELATED CLINICOPATHOLOGICAL ALTERATIONS IN DOGS AFFECTED WITH CHRONIC KIDNEY DISEASE
Renal secondary hyperparathyroidism (RHPT) is a common complication in humans and dogs affected with chronic kidney disease (CKD). RHPT is promoted mainly by the loss of nephrons and consequent hyperphosphatemia and its severity increases in parallel to the disease. The identification and …
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Bayesian Hierarchical Models for Data Extrapolation and Analysis in Rare and Pediatric Disease Clinical Trials
… of the drug cinacalcet in treating pediatric secondary hyperparathyroidism (HPT). The thesis then turns to methods useful in the study of X-linked adrenoleukodystrophy (X-ALD), a rare neurodegenerative disease for which Lorenzo’s Oil (LO) is one of the few available treatments. We offer a …